Ischemia, hepatic

The regulation of superoxide formation by SOD can affect both in vivo and ex vivo lipid peroxidation. Thus, SOD inhibited lipid peroxidation in cats following regional intestinal ischemia and reperfusion [33], Similarly, the treatment of rats with polyethylene glycol superoxide dismutase (PEG-SOD) prevented the development of lipid peroxidation in hepatic ischemia-reperfusion injury [34], Interesting data have been reported by Bartoli et al. [35]. They showed that SOD depletion in the liver of rats feeding with a copper-deficient diet... 

Acquired hyperammonemia Liver disease is a common cause of hyperammonemia in adults. It may be a result of an acute po cess, for example, viral hepatitis, ischemia, or hepatotoxins. Cirrhosis of the liver caused by alcoholism, hepatitis, or biiary obstruction may result in formation of collateral circulation around the liver. As a result, portal blood is shunted directly rto the systemic circulation and does not have access to the ter. The detoxification of ammonia (that is, its conversion to urea) is, therefore, severely impaired, leading to elevated levels of cicu lating ammonia. 

L. RubbiaBrandt, G. Mentha, A. Desmouliere, A. M. A. Costa, E. Giostra, G. Mo-las, H. Enzan, and G. Gabbiani, Hepatic stellate cells reversibly express alpha-smooth muscle actin during acute hepatic ischemia, Transplant Proc. 29 2390-2395 (1997). 

S. Suzuki, L. H. Toledo Pereyra, F. Rodriguez, and F. Lopez, Role of Kupffer cells in neutrophil activation and infiltration following total hepatic ischemia and reperfusion, Circ. Shock 42 204-209 (1994). 

Yoshino M. Contribution of TNF-alpha- and IL-6 in hepatic ischemia reperfusion injury. Toho Igakkai Zasshi 1996 42 530-543. 

Hepatic ischemia reperfusion si Liver TBA si liver damage based on marker enzymes T liver GSH 33... 

Bnlkley, G.B., Oshima, A., Bailey, R.W. Pathophysiology of hepatic ischemia in cardiogenic shock. Amer. J. Surg. 1986 151 87-96... 

Scheinman SJ, Poll DS, Wolfson S. Acute cardiac failure and hepatic ischemia induced by disopyramide phosphate. Yale J Biol Med 1980 53(5) 361-6. 

Jaeschke H. Mechanisms of liver injury II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions. Am J Physiol Gastrointest Liver Physiol 2006 290 1083-88. 

Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 2003 284 G15-G26. 

Tsung A, Hoffman RA, Izuishi K, Critchlow ND, Nakao A, Chan MH, Lotze MT, Geller DA, Billiar TR. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 2005 175(ll) 7661-8. 

Chouker A, Martignoni A, Schauer RJ, Dugas M, Schachtner T, Kaufmann I, Setzer F, Rau HG, Lohe F, Jauch KW, Peter K, Thiel M (2005) Alpha-glutathione S-transferase as an early marker of hepatic ischemia/ reperfusion injury after liver resection. World JSurg29(4) 528-534. doi 10.1007/s00268-004-7431-3... 

Llacuna, L., Mari, M., Garcia-Ruiz, C., and Fernandez-Checa, J.C., Morales A. Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Hepatology, 44 (2006) 561-572. 

Active as protector against hepatic ischemia-reperfusion injury in vivo. [119]... 

Lentsch AB, YoshidomeH, CheadleWG, Miller EN, Edwards MJ (1998) Chemokine involvement in hepatic ischemia/reperfusion injury in mice roles for macrophage inflammatory protein-2 and Kupffer cells. Hepatology 27 507-512... 

TzungSP, FaustoN, Hockenbery DM (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am J Pathol 150(6) 1985-1995 Uehara T, Beimett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner DA (2005) JNK mediates hepatic ischemia reperfusion injury. J Hepatol 42(6) 850-859 Uetrecht J (2008) Idiosyncratic drug reactions past, present, and future. Chem Res Toxicol 21 (l) 84-92... 

Fondevila, C., Busuttil, R.W., and Kupiec-Weglinski, J.W., Hepatic ischemia/reperfusion injury—a fresh look, Exp. Mol Pathol, 74 (2), 86, 2003. 

Hossain, M.A. et al.. Improved microcirculatory effect of D-allose on hepatic ischemia reperfusion following partial hepatectomy in cirrhotic rat liver, J. Biosci. Bioeng., 101, 369, 2006. 

Shinoda, M. Shimazu, M. Matsuda, S. Wakabayashi, G. Tanabe, M. Hoshino, K. Kamei, S. Koyasu, S. Kitajima, M. c-Jun iV-terminal kinase activation during warm hepatic ischemia/reperfu-sion injuries in a rat model. Wound Repair Regeneration 2W1, 70,314—319. 

Ikebe N, Akaike T, Miyamoto Y, Hayashida K, Yoshitake J, Ogawa M, et al. Protective effect of S-nitrosylated al-protease inhibitor on hepatic ischemia-reperfusion injury. J Pharamacol Exp Ther 2000 295 904-911. 

Vascular malformations of the liver are rare, except for the venous malformations misnamed hemangioma in adults. Most arteriovenous malformations of the liver are seen in hereditary hemorrhagic telangiectasia (Rendu-Weber-Osler) with hepatic ischemia, congestive heart failure, and... 

Vollmar B, Menger MD. Assessment of microvascular oxygen supply and tissue oxygenation in hepatic ischemia/reperfusion. Adv Exp Med Biol 1997 428 403-408. 

Jessup, JXl., Battle, P., Waller, H., Edmiston, K.H., Stolz, D.B., Watkins, S.C., Ixx ker, J., and Skena, K. (1999). Reactive nitrogen and oxygen radicals formed during hepatic ischemia-reperfiision loll weakly metastatic colorectal cancer cells. Cancer Res. 59(8), 1825-1829. Joseph, B., Marchetti, P., Formstecher, P., Kroemer, G., Lewensohn, R., and Zhivotovsky, B. (2002). Mitochondrial dysfunction is an essential step for killing of non-smaU cell lung carcinomas resistant to conventional treatment. Oncogene 27(1), 65-77. 

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