Nonparenchymal cells

V2. Van Berkel, T. J. C., Kruijt, J. K., Van Gent, T., and Van Tol, A., Saturable high affinity binding of low density and high density lipoprotein by parenchymal and nonparenchymal cells from rat liver. Biochem. Biophys. Res. Commun. 92, 1002-1008 (1980). 

Soto-Gutierrez A. 2007. Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines. Nat. Protoc. 2, 347-356. 

Approximately 30% of liver cells are nonparenchymal cells. Cell types located in the interlobular portal tracts include bile duct epithelial cells and connective tissue fibroblasts. Those located within the lobule interior are the rare fixed, natural killer lymphocytes (pit cells) and the more abundant endothelial cells lining the sinusoids, Kupffer cells, and stellate cells (also known as fat-storing or Ito cells). The recent... 

Skilleter, D.N., Paine, A.J., Stirpe, F. (1981). A comparison of the accumulation of ricin by hepatic parenchymal and nonparenchymal cells and its inhibition of protein synthesis. Bio-chim. Biophys. Acta 677 495-500. 

Tsung A, Hoffman RA, Izuishi K, Critchlow ND, Nakao A, Chan MH, Lotze MT, Geller DA, Billiar TR. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 2005 175(ll) 7661-8. 

Deleve, L. D. 1998. Glutathione defense in nonparenchymal cells. Seminars in liver Disease 18 403-413. 

Tanaka T, Fujishima Y, Hanano S, et al. (2004). Intracellular disposition of polysaccharides in rat liver parenchymal and nonparenchymal cells. Int. I. Pharm. 286 9-17. 

Laskin, Gardner CR (2003) Nonparenchymal cells, inflammatory macrophages, and hepatotoxicity. 

FIG. 6. Compartmental model proposed by Green et al. (1993) for liver and whole-body vitamin A metabolism. Compartment 11 is plasma retinol. PC, parenchymal cells NPC, nonparenchymal cells (assumed here to be perisinusoidal stellate cells) ROH, retinol RE, retinyl esters CM, chylomicrons. 

Bhatia SN, Balis UJ et al (1999) Effect of cell-cell interactions in preservation of cellular phenotype cocultivation of hepatocytes and nonparenchymal cells. FASEB J 13(14) 1883-1900... 

Belinsky, S. A., Bedell, M. A., and Swenberg, J. A., 1982, Effect of chronic ethanol diet on the replication, alkylation, and repair of DNA from hepatocytes and nonparenchymal cells following dimethylnitrosamine administration. Carcinogenesis 3 1293. 

A number of investigators have explored the potential roles of the nonparenchymal cells in the storage and metabolism of vitamin A in the liver. It has been shown convincingly that the Kupffer cells do not play an important role in the storage of vitamin A in the liver under normal conditions. Thus, when Kupffer cells were isolated from livers of rats on normal or on excess vitamin A-containing diets, the content of vitamin A in the Kupffer cells was found to be substantially less than that in hepatocytes (expressed on a per cell or per milligram DNA basis) (Linder et al., 1971 Hori and Kutamura, 1972 Peterson et aL, 1973). 

Evidence for retinol transfer, after its hepatic uptake, from parenchymal to nonparenchymal cells has been reported by Blomhoff etal. (1982). Lymph... 

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