Disopyramide phosphate

Disopyr mide. Disopyramide phosphate, a phenylacetamide analogue, is a racemic mixture. The dmg can be adininistered po or iv and is useful in the treatment of ventricular and supraventricular arrhythmias (1,2). After po administration, absorption is rapid and nearly complete (83%). Binding to plasma protein is concentration-dependent (35—95%), but at therapeutic concentrations of 2—4 lg/mL, about 50% is protein-bound. Peak plasma concentrations are achieved in 0.5—3 h. The dmg is metabolized in the fiver to a mono-AJ-dealkylated product that has antiarrhythmic activity. The elimination half-life of the dmg is 4—10 h. About 80% of the dose is excreted by the kidneys, 50% is unchanged and 50% as metabolites 15% is excreted into the bile (1,2). 

Isopropamide iodide Diisopropylaminoethyl chloride Disopyramide phosphate Propantheline bromide Diketene Ketazolam Pyrithyidione... 

Ryegonovin - Methylergonovine maleete Rynecrom - Cromolyn sodium Rythmical - Disopyramide phosphate Rythmoden - Disopyramide phosphate Rythmodul Disopyramide phosphate Rytmil - Bisacodyl Rytmilen - Disopyramide phosphate Rytmonorm - Propafenone HCI... 

Class I, Type 1A Antiarrhythmics disopyramide disopyramide phosphate procainamide hydrochloride quinidine bisulfate quinidine gluconate quinidine sulfate... 

Disopyramide phosphate is an odorless white, or slightly off-white free flowing powder. 

The infrared spectrum of disopyramide phosphate in a Nujol and Fluorolube split mull is shown in Figure 2. Band assignments are summarized below. ... 

Figure 3 - Proton Magnetic Resonance Spectrum of Disopyramide Phosphate...

Noise and single frequency off-resonance decoupled CMR spectra of disopyramide phosphate in deuterated water solution are shown in Figures 4 and 5.2 Shifts are reported in ppm downfield from the shift of tetramethyl silane as referenced to a shift of 67.4 ppm for dioxane which was used as an internal reference. 

Figure 4 - Noise decoupled carbon magnetic resonance spectrum of disopyramide phosphate. 

A chemical ionization mass spectrum of disopyramide phosphate contains a base peak at M/z = 340 which is due to the protonated free base of disopyramide phosphate. No peaks greater than 10% of the base peak are observed below M/z = 340. No peak due to the salt is present. 2... 

The solubility of disopyramide phosphate in various organic solvents is summarized in Table 1 below.3... 

Accurately weigh a portion of the disopyramide phosphate and add it to 50 mL of glacial acetic acid in a 250 mL Erlenmeyer flask. Titrate with 0.1 N perchloric acid to a potentiometric endpoint. A blank determination is performed and any necessary corrections made. Each mL of 0.1 N perchloric acid is equivalent to 21.87 mg of disopyramide phosphate.7... 

The analysis of disopyramide phosphate may be performed by UV spectrophotometric analysis employing 0.1 N sulfuric acid in absolute methanol as solvent. 

Several TLC systems are available for the analysis of disopyramide phosphate. Solvent, adsorbent, and detection parameters are summarized in Table 3. 

Disopyramide phosphate may be chromatographed under the following HPLC conditions.10... 

Disopyramide phosphate can be chromatographed as the free base. The free base is obtained by dissolving disopyramide phosphate chemical or capsule in an aqueous base medium and extracting into an organic solvent such as chloroform, ethyl ether, methylene chloride, etc.. Disopyramide is chromatographed under the following condi-... 

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