Hemoglobin normal range

Renal Effects. Renal function tests (serum creatinine and urate, urinary hemoglobin, protein and glucose) completed in 11 hexachloroethane workers were within the normal range (Selden et al. 1994). Plasma hexachloroethane levels in these workers, who wore protective equipment, were 7.3 + 6.04 pg/L at the time of the tests (Selden et al. 1993). Mild skin and mucous membrane irritation were reported in the exposed group, suggesting that exposure may have been through either the inhalation or dermal routes of exposure. 

We begin with the symptoms of sickle cell anemia. As the name implies, victims are frequently anemic that is, they have a content of hemoglobin in blood less than the normal range, the result of lysis of red blood cells, the carriers of hemoglobin (hemolytic anemia). In addition, disease victims are susceptible to chronic infections, may have enlarged spleens, and suffer intermittent bouts of pain, which can be severe, in the bones, joints, and periosteum. The disease can be debilitating. 

Hematological Effects. A report on 5 individuals (3 males, 2 females) who intentionally ingested 60-180 mb of 25% diazinon solution (estimated to deliver a dose of 240-400 mg/kg for males and 509-986 mg/kg for females) found that leucocyte counts (3,700, 95% polymorphonuclear), hemoglobin (16.3 g), and hematocrit (47) were all within normal ranges (Klemmer et al. 1978). 

No adverse hematological changes were observed in rats that were exposed to 24.4 or 174 mg/m of octaBDE dust for 8 hours/day for 14 consecutive days (IRDC 1978). Evaluation of hemoglobin, hematocrit, total erythrocyte count, and total and differential leukocyte counts showed no remarkable responses except for an elevation in leukocyte numbers. The observed increase in leukocyte counts was considered to be an unusual response by tlic investigators, although it was within the normal range for control rats in their laboratory. 

Laboratory tests showed that hemoglobin was 7.5 g/dL (normal range is 12-15 g/dL), and the reticulocyte count was 262 x 109/L (normal range is 50-100 X 109/L). The tests also indicated neutrophilia, a white cell count of 34 X 109/L (normal range is 4-11 x 109/L), and a platelet count of 328 X 109/L (normal range is 150-400 X 109/L). Renal function was normal. Malarial parasite screen and direct Coombs test were negative. Blood film showed nucleated red blood cells and anisocytosis with bite cells ... 

This observation seems to run directly counter to common assumptions (4) that, over the normal range of hemoglobin levels, the concentration of hemoglobin in the blood is directly related to the body iron stores (and to the amount and nutritional availability of iron in the diet). As such, this situation seemed worthy of further experimental study. 

Since the sensor signal was linear over the normal range of 2.1-6.9 U/g hemoglobin, and only decreased activities are of clinical relevance, the bienzyme electrode is suitable for the measurement of any clinically possible value. 

Figure 5 Effect of weekly intravenous infusions of mannose-terminal glucocere-brosidase on hemoglobin concentration in a 4-year-old boy with type 1 Gaucher disease. Solid black bars along the abscissa represent periods of enzyme treatment. A low dose of enzyme (9-12 U/kg) was administered between weeks 1 and 105 dosage was increased to 30 U/kg between weeks 131 and 320. Shaded areas represent the mean pretreatment and apparent steady-state values observed during the periods of low- and high-dose enzyme supplementation ( 1 SD). Normal range 11-15 g/dL. (From Ref. 10.)...

Enzyme dosage 60 U/kg every 2 weeks 0-24 months 30 U/kg every 2 weels 24-33 months 15 U/kg every 2 weeks 33-42 months Normal ranges Hemoglobin 11.5-15.5 g/dL (age 7-14 y)... 

Blood samples at the end of treatment revealed no significant net change in red blood cell counts, white blood cell counts, platelets, or hematocrit. The concentrations of albumin, uric acid, bilirubin, and liver enzymes remained within the normal range. Plasma free hemoglobin levels were less than 0.2 g/dL. The level of high-density lipoproteins showed no significant change with treatment (58). 

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