Hematological analyses

Routine gross and histopathologic examination of hematopoietic organs (spleen and bone marrow) and routine hematological analyses did not reveal any effects of nose-only exposure of rats to concentrations of endosulfan of up to 2 mg/m for 6 hours/day, 5 days/week for a total of 21 out of 29 days (Hoechst 1984c). 

Hematological Methods. Hematological analyses can Include the determination of the total hemoglobin concentration (In g%), the packed cell volume (PCV In %), the red blood cell count (In 10 /mm ) and reticulocytes count (In %), calculation of the red cell Indices, examination of a blood film, tests to demonstrate the presence of Inclusion bodies and of sickle cells, tests to evaluate the distribution of fetal hemoglobin (Hb-F) Inside the red cells, the red cell osmotic fragility, the concentration of serum Iron (SI), total Iron binding capacity (TIBC), and the survival time of the red cells. Details of all... 

The only information located regarding hematological effects of mirex in animals was found in a study in which an unspecified amount of mirex was applied to the skin of rabbits for 9 weeks, 5 days/week, for 6-7 hours/day (Larson et al. 1979a). Hematological analyses from these rabbits revealed no compound-related effects. 

Likewise, the hemodynamic effects of DCLHb (an intramolecularly cross-linked human Hb Baxter) in 14 critically ill patients were evaluated in a prospective, observational study. All of the subjects required vasopressor therapy to maintain adequate MAP and had secondary organ dysfunction prior to DCLHb treatment. Following a decision by the investigator to infuse, boluses (100 ml) of DCLHb were given up to a maximum of 500 ml. Each infusion was separated by 60-90 min. Hemodynamic parameters, norepinephrine and inotropic requirements, arterial and mixed venous blood gases, and urine output were monitored, and biochemical and hematological analyses were made before DCLHb administration and at multiple times up to 72 h postadministration. The main end-point employed to assess the efficacy of DCLHb as a vasopressor was maintenance of the MAP at approximately pre-infusion values concomitant with a reduction in norepinephrine requirements. This objective was met, and reductions in norepinephrine requirements were maintained at 24, 48, and 72h p < 0.01 at all time points). Thus, even in these critically ill patients, whose prognosis of survival was very poor, DCLHb seemed to have a beneficial effect. 

Hematological Effects. Routine blood parameters (hemoglobin, erythrocyte, leukocyte and thrombocyte levels) measured in 11 hexachloroethane workers did not differ from those of the controls (Selden et al. 1994). Plasma hexachloroethane levels in these workers, who wore protective equipment, were 7.3 + 6.04 pg/L at the time of the hematological analysis and 0.08 0.14 gg/L before production resinned (Selden et al. 1993). Mild skin and mucous membrane irritation were reported in the exposed group, suggesting that exposure may have been through either the inhalation or dermal routes of exposure. 

Hematological Effects. Diazinon exposure is not likely to produce adverse effects on the blood and bone marrow in humans. Hematological analysis performed on samples from 5 individuals (3 males, 2 females) who intentionally ingested 60-180 mL of 25% diazinon solution (estimated to deliver a dose of... 

Slight anemia was found upon hematological analysis of a woman who had taken 1.86 mg/kg/day... 

SYM-002 — Solid I2 SYM-002 was a multicenter, randomized, double-blind, placebo-controlled study that dosed patients for 6 months with 0.0, 1.5, 3.0 and 6.0 mg I2 in a ratio of 1 1 2 2. Healthy euthyroid mastalgia patients between the age of 18 and 50 who were unresponsive to conservative treatments, such as over-the-counter (OTC) analgesics, were eligible for the study. Subjects needed toi-dentify a history of at least 6 months of moderate or severe breast pain, and to document at least 6 days per cycle of a score >5 cm with VAS pain daily. Patients presented at least several diffuse nodules or increased thickness of breast tissue involving at least 25% of both breast surfaces. Subjects with a history of thyroid disease or positive TPO antibodies (TPOAb) were excluded, as well as those who started or stopped hormonal therapy within 6 months of enrollment. Laboratory assessment included a chemistry profile, hematology analysis, urinalysis and thyroid function tests (T3, T4, TSH, FT3). 

This stage involves structural analysis, histopathological analysis and hematological analysis of the retrieved implant using standard light optical microscopy, scanning electron microscopy (SEM) or other relevant techniques. Some of the studies using SEM require sample preparation. 

Szarfman A, Talarico L, Levine JG. Analysis and risk assessment of hematological data from clinical trials toxicology of the hematopoietic system. In Sipes IG, McQueen CA, Gandolfi AJ, editors. Comprehensive toxicology. Vol. 4. New York Elsevier Science, 1997, p. 363-79. 

Anonymous. Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies An individual patient data meta-analysis of nine randomized trials. J Clin Oncol 2005 23 5074-5087. 

Laboratory data may consist of many different collections of tests, such as ECG laboratory tests, microbiologic laboratory tests, and other therapeutic-indication-specific clinical lab tests. However, laboratory data traditionally consist of results from urinalysis, hematology, and blood chemistry tests. Traditional laboratory data can come from what are called local laboratories, which are labs at the clinical site, or from central laboratories where the clinical sites send their samples for analysis. Often when the laboratory data come from a central laboratory, there is no physical CRF page for the data and they are loaded into the clinical data management system directly from an electronic file. Local laboratory data may be represented with a CRF page such as this ... 

The association between low TPMT activity and excessive hematological toxicity has been recognized [31, 35, 37]. Molecular analysis of the TPMT genotype is able to identify patients at risk for acute toxicity from thiopurines. A recent study involving 180 children identified that the TPMT genotype plays an important role in a patients tolerance to 6-MP therapy [51]. Two of the patients, who were TPMT-de-... 

Last, it should always be kept in mind that it is rare for a change in any single hematologic parameter to be meaningful. Rather, because these parameters are so interrelated, patterns of changes in parameters should be expected if a real effect is present, and analysis and interpretation of results should focus on such patterns of changes. Classification analysis techniques often provide the basis for a useful approach to such problems. 

Weil, C.S. (1982). Statistical analysis and normality of selected hematologic and clinical chemistry measurements used in toxicologic studies. Arch. Toxicol. Suppl. 5 237-253. 

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