Haarmann and Reimer

Provisional Specification.—I, Johann Carl Wilhelm Fei-dinand Tiemann, member of the firm of Haarmann and Reimer, of Holzminden, residing at Berlin, Germany, do hereby deelare the nature of this invention to be as follows —... 

Williams, P. J. Sefton, M. A. Marinos, V. A. In Recent Developments in Flavor and Fragrance Chemistry Haarmann and Reimer International Symposium 12-15 April, 1992. VCH Kyoto, Japan, 1993 pp 283-290. 

Corporate Research and Flavor Division, Haarmann and Reimer GmbH, P.O. 

Pharmaceutical companies, which are interested in the terpenoid vitamins - A, E and K - will use citral as an intermediate and may therefore branch out into fragrances. For this reason, Hoffmann-La Roche once owned the fragrance company Givaudan. Similarly, salicylic acid was a common intermediate for some of the fragrance ingredients produced by Haarmann and Reimer and the aspirin produced by their parent company Bayer. The Reimer in question is the Reimer of the Reimer-Tiemann reaction and it was his chemistry upon which Bayer s business was built. Similarly, the Japanese company, Kuraray, manufactures synthetic rubber from butadiene and isoprene and so has diversified into terpenoid aroma chemical manufacture from these basic feedstocks. 

Originally, salicylaldehyde was prepared from phenol using chloroform in the Reimer-Tiemann reaction. The Reimer who discovered the reaction is the same person who founded a fragrance company, Haarmann and Reimer, an example of the entrepreneurial approach adopted by many nineteenth century academic chemists. 

Two excellent papers on YE aroma have arisen recently from Werkhoff s group at Haarmann and Reimer in Germany (13,14). Fifty sulfur compounds were reported in the first study (13) while 115 such components were described in the second paper (14). Aliphatic compounds, sulfur-substituted furans, thiophenes, thiazoles, 3-thiazolines, cyclic polysulfides, perhydro-l,3,5-dithiazines, a perhydro-1,3,5-oxathiazine, a perhydro-l,3,5-thiadiazine and aliphatic and heterocyclic dithiohemiacetals were all mentioned, and the structures of most of the newly identified compounds were confirmed by synthesis. These sulfur compounds elicit a wide variety of aromas but are often savory, e.g., meaty, vegetable-like, and YEs are a valuable source of potent components which provide meaty notes. 

The rapid development of the fragrance and avor industry in the nineteenth century was generally based on essential oils and related natural products. In 1876, however, Haarmann and Reimer started the rst production of synthetic aroma chemicals—vanillin and then coumarin, anisalde-hyde, heliotropin, and terpineol. Although aroma chemicals made a revolution in fragrances with top discoveries in the twentieth century, for many decades both avors and fragrances were manufactured with constituents of natural origin, the majority of which were essential oils. 

The largest producer of synthetic /-menthol is Symrise. The route, as shown in Fig. 8.33, was developed by Haarmann and Reimer (one of the companies that merged to form Symrise) and their then parent, Bayer. Several thousand tpa are produced by this route. 

Symrise A process for making enantiomerically pure (-) menthol from a mixture of menthol isomers. Formerly called the Haarmann and Reimer process. Developed by the German company Symrise, which acquired Haarmann and Reimer. The proprietary heterogeneous catalyst (not described) contains nickel. 

Merger of Holzminden companies Haarmann 8c Reimer and Dragoco. A new corporation is formed Symrise. 

Merger of Holzminden companies Haarmann 8c Reimer and Dragoco. A new corporation is formed Symrise. The latest milestone of the new company Symrise has been reached at the end of 2006 when the company became publicly traded. 

Ethylhexyl 2-cyano-3,3-diphenyl-acryl-ate Neo Heliopan 303 Octocrilene Octocrileno Octocrilenum Octocrylene 2-Propenoic acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl ester UV Absorber-3 Uvinul N-539. UV-B absorber for cosmetics, waterproof sunscreens. Used in flexible and rigid PVC in NC lacquers, varnishes, vinyl flooring, and oil-based paints in Aerosol and oil-based suntan lotions nonreactive with metallic driers. Liquid mp = -10° bpi.5 = 218° d = 1.051 insoluble In H2O, soluble in organic solvents. BASF Corp. Haarmann i Reimer GmbH. 

H-Benzimidazole-6sulfonic acid, 2-phenyl- EINECS 248-502-0 Ensulizole Eusolex 232 Neo Heliopan Hydro Novantisol Phenylbenzimidazole sulfonic acid 2-Phenylbenzimidazole-6 sulfonic acid 2-Phenyl-1H-benzimldazole-6sulfonic acid 2-Phenyl-1H-benz-imidazole-5-sulphonic acid. UV-B filter for sunscreen formulations. Used in creams, lotions and subscreens. Solid mp >300°. Haarmann i Reimer GmbH. 

AI3-07835 Antimol Benzoan sodny Benzoate of soda Benzoate sodium Benzoesaure (Na-salz) Benzoic acid, sodium salt Casweil No. 746 CCRIS 3921 EINECS 208-534-8 EPA Pesticide Chemical Code 009103 FEMA Number 3025 HSDB 696 Natrium benzoioum Sobenate Sodium benzoate Ucephan. Used as a fungicide preservative in pharmaceuticals and foods, especially in slightly acidic media as a clinical reagent (bilirubin assay). Solid mp >300° 4m = 223, 269 nm (H2O) soluble in H2O LDsO (rat orl) = 4,07 g/kg. Acefo Corp. Dinoval DSM Spec. Prods, Haarmann i Reimer GmbH Mallinckrodt Inc. Pentagon Chems. Ltd. 

Empirical C13H24O3 Properties M.w. 228.4 Toxicology TSCA listed Uses Cooling agent for cosmetics and foods Regulatory FEMA/GRAS approved Trade Name Synonyms Frescolat MGA [Haarmann 81 Reimer GmbH... 

International Flavors and Fragrances, Quest International, Givaudan, Takasago, Haarmann Reimer... 

H. Fiege and co-workers. Proceedings 2nd International Haarmann-Reimer Symposium, 1980, pp. 63—75. 

In 1874, Holzminden chemists Ferdinand Tiemann and Wilhelm Haarmann first succeeded in synthesising vanillin from coniferin. Holzminden became the site where vanillin was first produced industrially. Haarmann Reimer was the world s first factory in which synthetic scents and flavourings were produced [5]. 

Williams PJ, Sefton MA, Marinos VA (1993) 3rd international Haarmann Reimer symposium on recent developments in flavor and fragrance chemistry, Tokyo, p 283 Winterhalter P, Skouroumounis GK (1997) Adv. Biochem. Eng. 55 73 Fischer U, Trautmann S, Binder G, Wilke A, Goritz S (2000) Intensivierimg des Weinaromas. KTBL, Darmstadt, p 121... 

Once mycelia have been separated via continuous filtration from exhausted production media, citric acid may be recovered by using three different methods, such as direct crystallization upon concentration of the filtered liquor, precipitation as calcium citrate tetrahydrate, or liquid extraction. Since molasses are extremely rich in impurities, direct crystallization cannot be applied unless very refined raw materials, such as sucrose syrups or crystals, are used. The precipitation process (that is based on subsequent addition of sulfuric acid and lime to clarified fermentation broths) is used by the great majority of world citric acid manufacturers, including Archer Daniels Midland Co. (ADM) in the United States. Liquid extraction with mixtures of trilaurylamine, n-octanol, and Cio or Cn isoparaffin was used by Pfizer Inc. in Europe and Bayer Co. (formerly Haarmann Reimer Co., subsidiary of Miles) in the Dayton (OH, USA) and Eikhart (IN, USA) plants only (Moresi and Parente, 1999), even if such plants might have been shut down in 1998. 

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