H-gene

Else, K.J. and Wakelin, D. (1988) The effects of H-2 and non H-2 genes on the expulsion of the nematode Trichuris muris from inbred and congenic mice. Parasitology 96, 543-550. 

Abedi-Valugerdi M Mailer G (2000) Contribution of H-2 and non-H-2 genes in the control of mercury-induced autoimmunity. Int Immunol, 12(10) 1425-1430. 

Hultman P Nielsen JB (2001) The effect of dose, gender, and non-H-2 genes in murine mercury-induced autoimmunity. J Autoimmun, 17 27-37. 

J., and Flavell, R. A., 1983, The structure of a mutant H-2 gene suggests conversion-like events. Nature, 301 671. 

The current view of the genetic map of the H-2 gene complex is depicted in Figure 3.1. The linear order of the discrete loci of the complex has been established by analyses of multiple crossovers inside the complex. To date more than 40 such intra-H-2 recombinants have been analysed. The discrete loci, H-2K, Ir-IA, etc. are defined on the basis of two criteria (1) determination of functions or products demonstrably different from those of other genes in the complex (2) separation from adjacent loci by two or more intra-H-2 crossover events. 

Congenic resistant strains are inbred strains which are genetically identical to some standard inbred strain, such as C57BL/10 (BIO), except for the substitution of a distinct H-2 chromosomal segment from another strain. Thus a series of such strains may exist, all identical except that each carries a different set of H-2 genes. 

Shreffler, D. C. (1974). Genetic fine structure of the H-2 gene complex. In G. Edelman (ed.). Cellular Selection and Regulation in the Immune Response, p. 83 (New York Raven Press)... 

The protocol and data from a representative experiment using congenic-resistant mouse strains demonstrating the involvement of the H-2 gene complex in physiological lymphocyte interactions are shown in Figure 4.8. The DNP-primed B cells were derived from congenic-resistant BIO.A H-2 )... 

Among the various possible explanations for the failure of physiologic T-B cell cooperation to occur across the major histocompatibility barrier, certain possibilities which are trivial in terms of biological significance have been ruled out either by experimental design or by direct experimentation . These possibilities have been described and discussed in detail elsewhere and will not be reiterated here. These findings led us to develop the hypothesis, therefore, that the failure to observe cooperative responses when H-2 gene... 

In this complementation experiment, we have demonstrated that one or more Ir genes that control T-B cell interactions are localized in the K end of the H-2 gene complex. Thus, DBA/2 KLH-primed T cells cooperated with (C3H X C3H.OH)Fi and (C3H x C3H.OL)Fi DNP-primed B cells to make a secondary response to DNP-KLH, but not with C3H or (C3H x C3H.A)Fj DNP-primed cells. It must be emphasized that the carrier-primed DBA/2 T cells are histoincompatible with each of these B cell populations for both non-H-2 and H-2 determinants. The presence of foreign histocompatibility determinants provided by the C3H parent does not therefore prevent successful physiological T-B cell cooperation in Fj hybrids which have at least one complement of and genes derived from C3H.OH or C3H.OL parents. However, complementation with and genes derived from the... 

Group of transmembrane proteins engaged in the presentation of small peptide fragments to T-cells. Two classes of Major histocompatibility complex (MHC) molecules exist both of which are encoded by a highly polymorphic gene cluster. MHC class I and class II proteins present peptide fragments to CD8+ and CD4+ T-cells, respectively. The human MHC is also known as HLA, the murine MHC as H-2 complex. 

Messi M, Giacchetto I, Nagata K, Lanzavecchia A, Natoli G, Sallusto F. Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol 2003 4 78-86. 

Wakelin, D. and Donochie, A.M. (1983) Genetic control of immunity to Trichinella spiralis influence of H-2-linked genes on immunity to the intestinal phase of infection. Immunology 48, 343—350. 

Andrews, RW. and Boyse, E.A. (1978) Mapping of an H-2-linked gene that influences mating preference in mice. Immunogenet. 6, 265-268. 

Kiritoshi S, Nishikawa T, Sonoda K, Kukidome D, Senokuchi T, Matsuo T, Matsumura T, Tokunaga H, Brownlee M, Araki E (2003) Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells potential role in diabetic nephropathy. Diabetes 52 2570-2577. 

Sun D, Lennernas H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleisher D, Lee KD, Amidon GL (2002) Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs. Pharm Res 19 1400-1416. 

Mori, M., Nakagami, H., Morishita, R., et al. (2002) N141 mutant presenilin-2 gene enhances cell death and decreases bcl-2 expression. Life Sci., 70, 2567-2580. 

Tissenbaum, H.A. and Guarente, L. (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature, 410, 227-230. 

Pasini, D., Hansen, K.H., Christensen, J., Agger, K., Cloos, P.A. and Helin, K. (2008) Coordinated regulation of transcriptional repression bythe RBP2 H3K4demethylase and Polycomb-Repressive Complex 2. Genes and Development, 22, 1345-1355. 

Pendurthi, U.R., Okrno, S.T. and Tukey, R.H. (1993) Accumulation of the nuclear dioxin (Ah) receptor and transcriptional activation of the mouse cypla-1 and cypla-2 genes. Archives of Biochemistry and Biophysics, 306, 65-69. 

Junbo, H., Q. Li, W. Zaide, and H. Yunde, Receptor-mediated interleukin-2 gene transfer into human hepatoma cells. Int J Mol Med, 1999. 3(6) 601-8. 

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