Gene complexes

Davis MM, Chien YH, Gascoigne NR et al (1984) A murine T cell receptor gene complex isolation, structure and rearrangement. Immunol. Rev 81 235-258... 

Graham, H., Papalopulu, N., and Krumlauf. R. (1989). The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell 57 367-378. 

AS-C achaete-scute gene complex for sense organs CLN neuronal ceroid lipofuscinoses... 

Emi, Y., Ikushiro, S. and Iyanagi, T. (1996) Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. Journal of Biological Chemistry, 271, 3952-3958. 

Kortliike, C., Horstmann, K., Schwartz, E., Rohde, M., Binsack, R. and Friedrich, B. (1992) A gene complex coding for the membrane-bound hydrogenase of Alcaligenes eutrophus HI6. J. Bacterial., 174, 6277-89. 

Similar animal studies are useful in examining such diseases in a similar animal. The term similar animal simply means an animal that contracts the same disease because of a similarity in the disease-causing gene complex. As similarity exists in the genes between varying species, similar animals should be available for many of the diseases. 

Fig. 2. Structure of the UGTIA gene complex and the major UGTIAI, 1A7, and 1A9 polymorphisms.

Saeki M, Saito Y, Jinno Ft et al. Haplotype structures of the UGTIA gene complex in a Japanese population. Pharmacogenomics J2006 6 63-75. 

Walter, M.A., Surti, U., Hofker, M.H., et al. (1990). The physical organization of the human immunoglobulin heavy chain gene complex. EMBO J, 9, 3303-3313. 

E. B. Lewis, A gene complex controlling segmentation in Drosophila. Nature (London), 276, 565-570 (1978). 

Shichiti M, Tanaka A, Hirata Y. 2003. Intravenous gene therapy for familial hypercholesterolemia using ligand facilitated transfer of liposomes LDL receptor gene complex. Gene Ther. 10 827-831. 

A notable feature of the human CH gene complex is the presence of two clusters of related y, s and a C gene segments, thought to have arisen by gene duplication CY3-CYl-t / CE-Cal and (Flanagan and Rabbitts, 1982). Based on data... 

This approach soon led to the identification of 12 DH segments in the mouse heavy-chain gene complex (Sakano et al., 1981 Kurosawa et al., 1981 Kurosawa and Tonegawa, 1982). As predicted, these segments are flanked on both sides by RSS separated by 12 bp spacers. The DH were classified, by sequence similarity, into three families. One of the families consists of only one member located 700 bp 5 to the JH cluster. The other two families contain nine and two members and are lOto 80 kb from the J cluster (Wood and Tonegawa, 1983). Another DH segment was identified more recently (Feeney and Riblet, 1993). All the DH are located between the VH and JH. 

Hofker, M.H., Walter, M.A., Cox, D.W. (1989). Complete physical map of the human heavy chain constant region gene complex. Proc. Natl. Acad. Sci. USA 86,5567-5571. 

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