Growth hormone anabolic effects

K2. Kinney, J. M., Protein metabolism in human pathological states The effect of injury upon human protein metabolism. In Symposium on Protein Metabolism Influence of Growth Hormone, Anabolic Steroids, and Nutrition in Health and Disease (F. Gross, ed.), pp. 275-296. Springer, Berlin, 1962. 

The anabolic effects of somatropin are mediated by somatomedins or insulin-like growth factors. Somatropin is a synthetic polypeptide identical to the natural occurring growth hormone which stimulates longitudinal growth. Only preparations made with recombinant DNA technology are used nowadays. They can consist of 191 amino acids as growth hormone itself or 192 amino acids with one extra methionine. Somatropin is employed in the treatment... 

Mechanism of Action A synthetic form of triiodothyronine (T3), a thyroid hormone involved in normal metabolism, growth, and development. Possesses catabolic and anabolic effects. Therapeutic Effect Increases basal metabolic rate, enhances gluco-neogenesis, and stimulates protein synthesis. 

The growth hormone releasing hormone (or factor) (GHRH somatocrinin) was isolated only in 1982. It consists of either 40 or 44 amino acids. In addition to stimulating growth hormone production it also stimulates release of somatomedins, which are responsible for the many anabolic effects of growth hormone. Its production by recombinant DNA techniques has made it possible to undertake physiological studies on its activity. 

Rennie MJ. Claims for the anabolic effects of growth hormone a case of the Emperor s new clothes Br J Sports Med 2003 37 100-5. 

Demling RH. Comparison of the anabolic effects and complications of human growth hormone and the testosterone analogue, oxandrolone, after severe burn injury. Burns 1999 25(3) 215-21. 

Growth hormone (somatrem, somatropin) and corticotrophin use may be combined with that of anabolic steroids. Chorionic gonadotrophin may be taken to stimulate testosterone production (and prevent testicular atrophy). Similarly, tamoxifen (antioestrogen) may be used to attenuate some of the effects of anabolic steroids. 

The synthetic substances related to the male sex hormones (androgens) are called anabolic steroids . The principal effects of these substances are to promote the growth of skeletal muscle (anabolic effects) and the development of male sexual characteristics (androgenic effects). 

K37. Kowalewski, K., Effect of growth hormone and of an anabolic steroid on excretion of hydroxyproline in the urine of rats. Acta Endocrinol. 60, 321-328 (1965). 

Growth hormone (GH) General anabolic effects in many tissues... 

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