Granulocyte-macrophage colony-stimulating receptors

Kim MS, Day CJ, Morrison NA. MCP-1 is induced by receptor activator of nuclear factor-a B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation. J Biol Chem 2005 280(16) 16163-16169. 

Lopez, A. F., Williamson, D. J., Gamble, J. R., Begley, C. G., Harlen, J. M., Klebanoff, S. J., Waltersdorph, A., Wong, G., Clark, S. C., Vadas, M. A. (1986). Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. 

Raines, M. A., Liu, L. D., Quan, S. G., Joe, V., DiPersio, J. F., Golde, D. W. (1991). Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor. Proc. Natl. Acad. Sci. USA 88, 8203-7. 

Vadas, M. A. (1988). Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates fMet-Leu-Phe receptors on human neutrophils. Immunol. 64,519-25. 

Edwards, S. W., Watson, F., MacLeod, R., Davies, J. M. (1990). Receptor expression and oxidase activity in human neutrophils Regulation by granulocyte-macrophage colony-stimulating factor and dependence upon protein biosynthesis. Biosci. Rep. 10, 393-401. 

McColl, S. R., Paquin, R., Menard, C., Beaulieu, A. D. (1992). Human neutrophils produce high levels of the interleukin 1 receptor antagonist in response to granulocyte/ macrophage colony-stimulating factor and tumor necrosis factor a. J. Exp. Med. 176, 593-8. 

Granulocyte macrophage-colony stimulating factor, GM-CSF 14 kD 51 kD, GM-CSF-R, receptor with associated tyrosine kinase... 

Quelle FW, Sato N, Witthuhn BA, Inhorn RC, et al. 1994. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell biol. 14 4335-4341. 

Inhorn, R. C., Carlesso, N., Durstin, M., Frank, D. A., and Griffin, J. D., Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750. Proc. Natl. Acad. Sci. USA 92, 8665-8669 (1995). 

Several cytokine receptors are present in prostate tumors and in prostate cancer cell lines. These include the granulocyte-macrophage colony-stimulating factor receptors (GM-CSF-R) and macrophage colony-stimulating factor receptor (M-CSF-R) (R7, RIO, S4). The presence of interleukin receptors in the prostate tumor which bind interleukins such as IL-2, IL-3, and IL-6 may play a role in hormone-dependent as well as in hormone-refractory prostate cancer tumors (Cl3, R6). However, the importance of these receptors needs to be illuminated. 

R7. Rivas, C. I., Vera, J. C., Delgrado-Lopez, F., Heany, M. L., Guaiquil, V. H., etal., Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer. Blood 91, 1037-1043 (1998). 

Cytokine subfamily 2 includes proteins with heterodimeric a—(3 or ct-gpl30 receptors. Thus, granulocyte macrophage colony stimulating factor (GM-GSF), IL-3 and IL-5 act via a—(3 receptors and share (3 receptors. Cardiotrophin-1 (GT-1), ciliary neurotrophic factor (CTNF), IL-6, IL-1, leukaemia inhibitory factor (LIF) and oncostatin M (OSM) act via heterodimeric a-gpl30 receptors with a shared gpl30 receptor subunit. Leucocyte-derived cytokines of this family have immunomodulatory and haematopoietic effects. 

Diederichs, K., Boone, T., and Karplus, P. A. (1991). Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor. Science 254, 1779-1782. 

Murphy, J. M., Ford, S. C., Wiedemann, U. M., Garr, P. D., Ollis, D. L., and Young, I. G. (2003). A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5. J. Biol. Chem. 278, 10572-10577. 

Woodcock, J. M., McClure, B. J., Stomski, F. C., Elliott, M.J., Bagley, C.J., and Lopez, A. F. (1997). The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF, interleukin-3, or interleukin-5. Blood 90, 3005—3017. 

Mattoli, S. (1991). Interleukin 1 binds to specific receptors on human bronchial epithelial cells and upregulates granulocyte-macrophage colony-stimulating factor synthesis and release. Am. J. Respir. Cell Mol. Biol. 4, 519-524. 

---