Eosinophil functions

Sabroe I, Peck MJ, Van Keulen BJ, et al. A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem 2000 275(34) 25985-25992. 

Eosinophil infiltration is a major feature of asthma and allergic reactions [203], These cells are not abundant during the acute phase of the response, but increase in number and account for 10-80% of the total cell infiltrate during the late phase. Furthermore, major basic protein (MBP), which is released from eosinophil granules, causes respiratory epithelial damage [204]. Since PAF is a potent activator of eosinophil functions [205], BN 52021 may interfere with the late phase response. 

Lopez, A. F., Williamson, D. J., Gamble, J. R., Begley, C. G., Harlen, J. M., Klebanoff, S. J., Waltersdorph, A., Wong, G., Clark, S. C., Vadas, M. A. (1986). Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. 

Furthermore, IL-10 downregulates eosinophil function and activity, and suppresses lL-5 production by human resting ThO and Th2 cells... 

Silberstein DS (1995) Eosinophil function in health and disease. Crit Rev Oncol Hematol 19(1) 47-77... 

GM-CSF IL-1, TNF, LPS, retroviral infection Granulocyte, eosinophil and macrophage colony stimulation, enhanced neutrophils/ eosinophil function IL-1, TNF, PGE2, 02 Macrophages, eosinophils, granulocytes... 

PI3 kinase Wortmannin, LY 294002 Inhibit kinase Multiple growth factors and cytokines Inhibit neutrophil (T4) and eosinophil function (B16)... 

LOPEZ, A.F., SANDERSON, C.J., GAMBLE, J.R., CAMPBELL, H.D., YOUNG, I.G. VADAS, M.A. (1988) Recombinant interleukin 5 is a selective activator of human eosinophil function. Journal of Experimental Medicine, 167, 219-224. 

It is thus proposed that lipoxygenase products derived from the eosinophils themselves, as well as from other cells, are active in modulating eosinophil function. 

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