Ligand binding sites

Fig. 13. Model for the ligand binding site of the receptor (87). The view of the receptor is from the extracellular face of the plasma...

Preconcentration of metal cations is also achieved by providing ligand binding sites in polymer layers, e.g. 4-methyl-4 -vinyl-2,2 -bipyridine for Fe " and Cu ". Carbon paste electrodes containing dimethylglyoxime or o-phenanthroline... 

The affinity (Kj values) observed for [ H]MDA and [ HJMDMA binding were similar to the effective doses (i.e., ED50 or K] values) of MDA and MDMA reported for various pre- and postsynaptic monoamine markers, such as serotonin and dopamine release (Johnson et al. 1986), monoamine transport (Steele et al. 1987), and multiple brain, ligand binding sites (Battaglia et al. 1988). 

P11 ap11, C. Contreras, P.C. O Donohue, T.L and Quirion, R. Autoradiographic distribution of (3H)dexoxadrol, a phencyclidine-related ligand, binding sites in rat and human brain. Neurosci Lett (in press). 

Schwartz, T. W., Locating ligand-binding sites in 7TM receptors by protein engineering, Curr. Opin. Biotech-nol., 5, 434-444, 1994. 

Vaughan R.A., Parnas M.L., Gaffaney J.D. et al. Affinity labeling the dopamine transporter ligand binding site. J. Neurosci. Methods. 143 33, 2005. 

Several other C-type lectins have since been found in Toxocara (Fig. 12.4). Two are simple variants of TES-32, differing by 13-17% in amino acid sequence but with identical ligand binding sites these have been termed CTL-2 and CTL-3. It has yet to be determined whether these additional lectins are alleles or represent different coding loci, and it has not been established whether they are also secreted. A fourth lectin, CTL-4, corresponds to TES-70 (Loukas et al, 2000), as described below. In addition, there is some evidence that TES-45 and TES-55 are lectins, as detailed below. 

---