Immunoglobulin-like domains

Figure 13.24 Six subfamilies of receptor tyrosine kinases involved in cell growth and differentiation. Only one or two members of each subfamily are indicated. Note that the tyrosine kinase domain is interrupted by a "kinase insert region" in some of the subfamilies. The functional significance of the cysteine-rich and immunoglobulin-like domains is unknown.

MHC molecules are composed of antigen-binding and immunoglobulin-like domains... 

The class 1 MHC structure is divided into two globular regions (Figure 15.18). One region is built up from the two immunoglobulin-like domains a3... 

Figure 15.18 (a) Schematic representation of the path of the polypeptide chain in the structure of the class I MHC protein HLA-A2. Disulfide bonds are indicated as two connected spheres. The molecule is shown with the membrane proximal immunoglobulin-like domains (a3 and Pzm) at the bottom and the polymorphic al and a2 domains at the top. 

Many cell-surface receptors contain immunoglobulin-like domains. 

Many other cell-surface proteins involved in immunological recognition utilize immunoglobulin-like domains as structural elements. Immunoglobulin domains have been classified into five types, namely V (like antibody variable... 

Wang, J., et al. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature 348 411-418, 1990. 

The integrin a 4(3 7 is restricted to leukocytes and can bind not only to VCAM1 and fibronectin, but also to MAdCAM the mucosal addressin or homing receptor, which contains immunoglobulin-like domains related to VCAM-1. 

Both receptors have seven immunoglobulin-like domains in their extracellular region, a single-membrane-spanning domain, and an intracellular split tyrosine kinase domain... 

All effects of the IL-1 family are exerted via their receptors, which are present on a variety of different cell types. There are two known IL-1 receptors. The first, type I (IL-1RI) is an 80-kDa formation found mainly on T cells and fibroblasts the second, type II (IL-1RII) is present on cells, monocytes, neutrophils, and heptoma cells and is approximately 60 kDa in size. From sequence analysis these molecules are believed to belong to the Ig-superfamily, the extracellular portion of the receptors consisting of three immunoglobulin-like domains of approximately 100 residues each [27,28]. The IL-1RI receptor... 

Under the electron microscope titin appears as a flexible beaded string 4 nm in diameter. Most of the molecule is made up of repetitive domains of two types. In human cardiac titin there are 132 folded domains that resemble type III fibronectin repeats and 112 immunoglobulin-like domains.98 In a "PEVK region," between residues 163 and 2174, 70% of the residues are Pro, Glu, Val, or Lys. The titin molecule may be organized as polyproline helices in this elastic region.1023 At the C terminus of titin 800 residues, including a Ser / Thr protein kinase domain, are found within the M-line. 

Mues, A., van der Ven, P. F., Young, P., Furst, D. O., and Gautel, M. (1998). Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin. FEBSLett. 428, 111-114. 

Mastov, K. E., Friedlander, M. Blobel, G. (1984). The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature, 308 37-43. 

Layton, J. E., Hall, N. E., Connell, F., Venhorst, J., and Treudein, H. R. (2001). Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor./. Biol. Chem. 276, 36779-36787. 

Plun-Favreau, H., Ferret, D., Diveu, C., Froger, J., Chevalier, S., Lelievre, E., Gascan, H., and Chabbert, M. (2003). Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor./. Biol. Chem. 278, 27169-27179. 

Vollmer, P., Oppmann, B., Voltz, N., Fischer, M., and Rosejohn, S. (1999). A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding. Eur. J. Biochem. 263, 438-446. 

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