Globulin, cold-insoluble

Of the several other protein components of the extracellular matrix, the best understood is fibronectin. This glycoprotein is a heterodimer composed of two very similar, but not identical, disulfide-bonded polypeptide chains (Mr — 220,000). It is found in several forms as a bound complex on the surface of cells such as fibroblasts as large aggregates in the extracellular space and in a modified form as the so-called cold-insoluble globulin (i.e., it readily precipitates at 0°C) in plasma. 

Cold insoluble globulin 0.1-0.3 falcon dishes RE-test emulsion PVC fibroblasts macrophages platelets adhesion enhanced (8) phagocytosis enhanced (9) thrombus enhanced (10)... 

Proteoglycans appear to be associated with the substrate-adhesion sites of normal and virus-transformed murine cells.Cell-surface heparan sulphate is capable of cross-linking the cell-surface fibronectin and substrate-bound cold-insoluble globulin in an initial adhesion step. ... 

Mosesson M.W. and Umfleet RA., 1970, The cold-insoluble globulin of human plasma. Purification,... 

The response of rat liver to inflammation is manifested by an increased production of i-acid glycoprotein. The carbohydrate moieties of human-plasma lipoproteins have been analysed for hexose, hexosamine, and sialic acid. A major plasma glycoprotein (cold-insoluble globulin) contains sialic acid (1.2%), hexose (1.8%), and hexosamine (2.1%). ... 

A similar structure has been reported for the N-glycosidic oligosaccharide units in bovine cold-insoluble globulin (Kobata 1979)... 

Stathakis NE, Mosesson MW, Chen AB, Galanakis DK 1978. Cryoprecipitation of fibrin-fibrinogen complexes induced by the cold-insoluble globulin of plasma. Blood 51(6) 1211-1222. 

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