Follicle-stimulating hormone measurement

Reichert LE Jr (1976) Follicle-stimulating hormone measurement by a rat testes tubule receptor assay. In Blecher M (ed) Methods in Receptor Research, Part I. Marcel Dekker, Inc., New York and Basel, pp 99-118 Reichert LE, Bhalla VK (1974) Development of a radioligand receptor assay for human follicle stimulating hormone. Endocrinology 94 483-491... 

Oosterhuis, G. J. E., Lambalk, C. B., Michgelsen, H. W. B., de Koning, C. H., Vermes, I., and Schoemaker, J., Follicle-stimulating hormone measured in unextracted urine A reliable tool for easy assessment of ovarian capacity. Fertil. Steril. 70, 544-548 (1998). 

Time-resolved approaches for multi-analyte immunoassays have been described recently. Simultaneous determination of LH, follicle stimulating hormone (FSH), hCG, and prolactin (PRL) in a multisite manual strip format has been reported. 88 Four microtiter wells are attached to a plastic strip, two-by-two and back-to-back, such that the wells can be read on a microtiter plate reader. In a quadruple-label format, the simultaneous quantitative determination of four analytes in dried blood spots can be done using europium, samarium, dysprosium, and terbium. 89 In this approach, thyroid-stimulating hormone, 17-a-hydroxyprogesterone, immunoreactive trypsin, and creatine kinase MM (CK-MM) isoenzyme are determined from dried blood samples spotted on filter paper in a microtiter well coated with a mixture of antibodies. Dissociative fluorescence enhancement of the four ions using cofluorescence-based enhancement solutions enables the time-resolved fluorescence of each ion to be measured through four narrow-band interference filters. 

Given the above preclinical observations, patients in a clinical study were monitored closely during treatment (including measurement of testosterone, luteinizing hormone, follicle-stimulating hormone levels, alkaline phosphatase, and serum vitamin A concentrations). This phase I clinical study of TAG-101 was conducted to determine the safety, toxicity, and pharmacokinetics of this agent in patients with advanced cancer. Currently, the drug is in a phase I/II clinical trial for advanced hepatocellular carcinoma. 

Measurement of Luteinizing Hormone, Follicle-Stimulating Hormone, and Free a Subunits... 

Burger HG, Dudley EC, Hopper JL, Groome N, Guthrie JR, Green A, et al. Prospectively measured levels of serum follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohort of women. 

Serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone concentrations were measured in rats exposed for 13 weeks to PCB 28 or PCB 77 in food (Desaulniers et al. 1997). No changes, relative to the control group, were observed at doses of 500 pg/kg/day PCB 28 or 75 pg/kg/day PCB 77. Acute intraperitoneal administration of PCB 126 in adult rats caused decreased... 

Monitoring concentrations of female hormones is important for female disease diagnostics as well as for fetal health monitoring. The most important female cycle biomarkers, which are typically measured in clinical laboratory tests or commercial test strips, include follicle stimulating hormone (FSH) as a marker of non-pregnancy, luteinizing hormone (LH) as a marker of ovu-... 

Several studies evaluated endocrine measurements, specifically testosterone and follicle stimulating hormone (FSH), as primary or secondary endpoints. Testosterone is of clinical importance both as a risk factor for cancer and as part of the initial evaluation of male infertility. FSH is also measured as an initial evaluation of infertility in both men and women. Despite the substantial number of studies, results were conflicting and no significant effect of soy product consumption was found in men, pre- or postmenopausal women (Balk et al., 2005). 

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