Recommended dietary allowance folates

Except during pregnancy and lactation, do not give folic acid in therapeutic doses greater than 0.4 mg/day until pernicious anemia has been ruled out. Do not include daily doses exceeding the Recommended Dietary Allowance in multivitamin preparations if therapeutic amounts are necessary, give folic acid separately. Elderly It may be prudent to consider the status of folate in people older than 65 years of age. 

An important indication for folic acid has become the prevention of neural tube defects when given to women three months before conception and during the first trimester. The Recommended Dietary Allowance (RDA) for folate equivalents for pregnant women is 600-800 pg, twice the normal RDA of 400 pg for women who are not pregnant. 

The amount of foHc acid required for daily intake is estimated based on the minimum amount required to maintain a certain level of semm folate. The recommended dietary allowance (RDA) for foHc acid accounts for daily losses and makes allowances for variation in individual needs and bioavailabiHty from food sources (85). The U.S. recommended daily allowance for adults is 400 )Ug and for pregnant women is 800 X (Table 4). 

Bailey, L. B. (1992). Folate—Evaluation of new recommended dietary allowance. J. Am. Diet. Assoc. 92, 463. 

Tree nuts can be good dietary sources (>10% of recommended dietary allowances [RDA] or adequate intake [Al]) of most vitamins except vitamins A and cobalamin (B,2). At suggested consumption level (1.5 ounces or 42.5g/day), acorn and pine nuts are excellent sources of folate and vitamin K (Table 2.7). In case of thiamin (Bj), niacin (B3), and pyridoxine (Bg), tree nuts offer alternative sources of these vitamins when more abundant animal sources are not available or are not consumed. 

Recommended Dietary Allowances, 10th ed., 1989, NRC-National Academy of Sciences, p. 285. ihe RDA are expressed in terms of "total" folacin, that is, the amount of folic acid activity available from all food folates. 

National Research Council, Food and Nutrition Board, and Institute of Medicine (1998) Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B-6, folate, vitamin B-12, pantothenic add, biotin, and choline. In Recommended Dietary Allowances., pp. 374-389. Washington, DC. National Academy Press. 

Folate is a water-soluble vitamin. The recommended daily allowances (RDAs) of folate for the adult man and woman are 20fJ and 101) pg, respectively. The RDA is defined in the Preface. Folate is critically important for growth, and for this reason it is required in increased amounts during pregnancy (400 pg. The need for dietary folate remains elevated after pregnancy and during lactation because of the Irans-... 

The folate requirement is the minimum amount necessary to prevent deficiency. Dietary recommendations for populations, however, must allow a margin of safety to cover the needs of the vast majority of the population. As is the case with most nutrients, the margin of safety for folate requirement corresponds to two standard deviations above the mean requirement for a population and should therefore meet the needs of 97.5% of the population. Thus, international dietary recommendations contain allowances for individual variability, the bioavailability of folate from different foodstuffs, and periods of low intake and increased use. Current international folate recommendations for FAO/ WHO, USA/Canada, and the European Union are listed in Table 2. 

Table 2 Recommended dietary folate allowances for various population groups (pgday ...

The lack of hard evidence about the extent of supplementation required in pregnancy prompted the development of a laboratory-based assessment of metabolic turnover, which involved the assay of total daily folate catabolites (along with intact folate) in the urine of pregnant women. The rationale of the procedure was that this catabolic product represents an ineluctable daily loss of folate, the replacement of which should constitute the daily requirement. Correcting for individual variation in catabolite excretion and the bioavailability of dietary folate, the recommended allowances based on this mode of assessment are in close agreement with the latest recommendations of the USA/Canada and FAO/WHO. The data produced by the catabolite-excretion method may provide a useful adjunct to current methods... 

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