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Feline leukemia

PMEA and its congeners are more effective in vivo than could be predicted from their in vitro potency. While less potent as an antiretrovirus agent than AZT in vitro, PMEA proved clearly superior to AZT when the two drugs were compared for their effectiveness in vivo, in mice infected with murine Moloney sarcoma virus [51,52]. PMEA was also shown to be effective against various other retrovirus infections, including Friend leukemia virus (FLV), Rauscher leukemia virus (RLV), and LP-BM5 (murine AIDS) virus infection in mice, feline leukemia virus (FeLV) or feline immunodeficiency virus (FIV) infection in cats, and SIV infection in macaque (rhesus) monkeys (for review, see Ref. 53). In the latter model [54], again PMEA proved far superior to AZT in suppressing several parameters of the disease. [Pg.321]

The best solution is to confine cats in their homes. Many owners say that they cannot confine a cat—the cat would go crazy. It is not unfair for cats to remain in the house throughout their lives. In such a condition a cat will live an average of 17 years, while a free-roaming cat will live only three-five years. Indoor cats avoid exposure to feline leukemia and rabies. The greatest danger to outdoor cats is automobiles, which kill 1.5 million a year. And who is to say that the pleasures of the cat are more important than the lives of the birds ... [Pg.16]

Fig. 11. Structures of oncoretrovirus receptor-binding domains. Left The receptorbinding domain of Friend murine leukemia virus (Fass et al, 1997). Right The homologous domain from subgroup B feline leukemia virus (Barnett et al, 2003). The positions of the variable subdomains and conserved /9-sandwich scaffold are indicated. The histidine residue critical for receptor binding-induced activation of membrane fusion by this virus group is indicated at the extreme amino terminus in the feline leukemia virus structure, but this residue was not seen in the electron density of the Friend receptor-binding domain. Fig. 11. Structures of oncoretrovirus receptor-binding domains. Left The receptorbinding domain of Friend murine leukemia virus (Fass et al, 1997). Right The homologous domain from subgroup B feline leukemia virus (Barnett et al, 2003). The positions of the variable subdomains and conserved /9-sandwich scaffold are indicated. The histidine residue critical for receptor binding-induced activation of membrane fusion by this virus group is indicated at the extreme amino terminus in the feline leukemia virus structure, but this residue was not seen in the electron density of the Friend receptor-binding domain.
Because these studies of feline leukemia may someday play a crucial role in the discovery of a cure for AIDS in human beings, the experiments, as expensive as they are, must continue. [Pg.88]

Fevaxyn Pentofel (combination vaccine containing recombinant feline leukemia viral antigen as one component) Fort Dodge Laboratories immunization of cats against various feline pathogens 1997... [Pg.41]

Eurifel FELV (vaccine consisting of an engineered canarypox virus into which the gag, env and a partial pol gene of feline leukemia virus have been inserted) Merial Immunization of cats against feline leukemia virus 2000... [Pg.42]

Wheeler, E.F. Roussel, M.F. Hampe, A. Walker, M.H. Fried, V.A. Look, A.T. Rettenmier, C.W. Sherr, C.J. The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences. J. Virol., 59, 224-233 (1986)... [Pg.581]

Weinbersterols disodium sulfate A (284), B (285) Sponge, Petrosia weinbergi Feline leukemia virus, HIV-I Uknown [208]... [Pg.535]

T7i5>. Another study of Spongosorites sp. revealed the presence of dragmacidin d (305), which is active against feline leukemia <92JOC4772>. [Pg.243]

Over 195 patents have been filed since 1986 in which zidovudine (152) is mentioned. Potent side effects preclude the widespread use of zidovudine against the AIDS virus. In addition to having activity against the AIDS virus, zidovudine has activity against the feline leukemia virus and gramnegative bacterial infections <86EUP199451, 86EUP217580>. [Pg.411]

MLV-related virus (spleen necrosis virus, mouse, and feline leukemia viruses). [Pg.1216]

Clark N, Kushner NN, Barrett CB, Kensil CR, Salsbury D, Cotter S (1991) Efficacy and safety field trials of a recombinant DNA vaccine against feline leukemia virus infection. J Amer Veterin Med Assoc 199 1433-1443... [Pg.269]

Murine polyoma Lymphosarcoma Simian virus 40 (SV40) Yaba pox Feline leukemia Herpesvirus saimiri Herpesvirus saimiri... [Pg.131]

Feline leukemia (FeLV) Feline sarcoma (FeSV) Woolly monkey fibrosarcoma (SSV-1) Gibbon ape... [Pg.132]

Abbreviations Ad, Adenovirus EBV, Epstein-Barr virus FeLV, Feline leukemia virus FeSV, Feline sarcoma virus GaLV, Gibbon ape lymphosarcoma virus HVA, Herpesvirus ateles HVS, Herpesvirus saimiri MV, Monkey virus PML, Progressive multifocal leukoencephalopathy associated with three SV40-like viruses SSV-1, Woolly monkey fibrosarcoma virus SV, Simian virus. [Adapted from (477)]. [Pg.134]

Sarma, P.S., A. Sharar, V. Walters, and M. Gardner. 1974. A survey of cats and humans for prevalence of feline leukemia-sarcoma virus neutralizing serum antibodies. Proc. Soc. Exp. Biol. Med. 145 560-564. [Pg.394]

Gunasekera, S.P. and Cross, S.S. (1992) Fistularin 3 and 11-ketofistularin 3. Feline leukemia virus active bromotyrosine metabolites from the marine sponge Aplysina archeri. J. Nat. Prod., 55, 509-512. [Pg.1231]

See other pages where Feline leukemia is mentioned: [Pg.85]    [Pg.347]    [Pg.349]    [Pg.679]    [Pg.3911]    [Pg.42]    [Pg.88]    [Pg.646]    [Pg.677]    [Pg.545]    [Pg.157]    [Pg.487]    [Pg.688]    [Pg.3627]    [Pg.247]    [Pg.257]    [Pg.229]    [Pg.230]    [Pg.129]    [Pg.130]    [Pg.386]    [Pg.386]    [Pg.387]    [Pg.70]    [Pg.250]    [Pg.250]   
See also in sourсe #XX -- [ Pg.70 , Pg.250 ]



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