Feline leukemia/sarcoma virus

Sarma, P.S., A. Sharar, V. Walters, and M. Gardner. 1974. A survey of cats and humans for prevalence of feline leukemia-sarcoma virus neutralizing serum antibodies. Proc. Soc. Exp. Biol. Med. 145 560-564. 

PMEA and its congeners are more effective in vivo than could be predicted from their in vitro potency. While less potent as an antiretrovirus agent than AZT in vitro, PMEA proved clearly superior to AZT when the two drugs were compared for their effectiveness in vivo, in mice infected with murine Moloney sarcoma virus [51,52]. PMEA was also shown to be effective against various other retrovirus infections, including Friend leukemia virus (FLV), Rauscher leukemia virus (RLV), and LP-BM5 (murine AIDS) virus infection in mice, feline leukemia virus (FeLV) or feline immunodeficiency virus (FIV) infection in cats, and SIV infection in macaque (rhesus) monkeys (for review, see Ref. 53). In the latter model [54], again PMEA proved far superior to AZT in suppressing several parameters of the disease. 

Abbreviations Ad, Adenovirus EBV, Epstein-Barr virus FeLV, Feline leukemia virus FeSV, Feline sarcoma virus GaLV, Gibbon ape lymphosarcoma virus HVA, Herpesvirus ateles HVS, Herpesvirus saimiri MV, Monkey virus PML, Progressive multifocal leukoencephalopathy associated with three SV40-like viruses SSV-1, Woolly monkey fibrosarcoma virus SV, Simian virus. [Adapted from (477)]. 

Spumavirus (the foamy viruses) Lentivirus (human, feline, simian, and bovine immunodeficiency viruses). Enveloped, spherical, negative-sense, and ssRNA (two identical strands). Synthesis occurs in the host cell cytoplasm maturation involves budding through the host cell plasma membrane. These viruses contain the enzyme reverse transcriptase. The retroviruses (except the Spumavirus and Lentivirus genera) represent the RNA tiunor viruses, causing leukemias, carcinomas, and sarcomas. 

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