Fatigue muscular

Pulmonary irritation, headache, nausea, fatigue, muscular weakness, liver and kidney pathology (3)... 

Working for too lengthy a period, which produces fatigue. Muscular fatigue results from overloading of individual muscle groups, either... 

Four different localizations of fatigue can be identified (a) decreased central command (b) decreased activation of the muscle membrane and the T-tubular system (c) decreased Ca release from the SR and (d) decreased response to the Ca release by the contractile proteins. The first two are partly extra-muscular while c and d are intramuscular responses to the excitation of the muscle membrane and often defined as excitation-contraction coupling. 

Bigland-Ritchie, B. Woods, J.J. (1984). Changes in muscle contractile properties and neural control during human muscular fatigue. Muscle Nerve 7. 691-699. 

Dawson, M.J., Gadian, D.G., Wilkie, D.R. (1978). Muscular fatigue investigated by phosphorus nuclear magnetic resonance. Nature 274, 861-866. 

Signs and Symptoms Clinical symptoms in humans similar to that seen in smallpox although often milder. Symptoms include extreme fatigue, fever, muscular, and back pain, with evolution of discolored spots (maculas) progressing successively to elevated bumps (papules), blisters (vesicles), pus filled pimples (pustules), and finally scabs. In addition, infected persons experience enlarged neck and groin lymph nodes. Vaccination with the smallpox vaccine immunizes against monkeypox. 

Easy fatigue, mild weakness, muscular twitching, fasciculations, cramps, generalized weakness, including muscles of respiration, with dyspnea and cyanosis. 

Symptoms during the initial phase are characterized by nonspecific and relatively mild respiratory illness, muscular pain, malaise, fatigue, low-grade fever, and nonproductive cough. Patients sometimes complain of mild chest discomfort. 

Further observations. Wilson3 studied the effect of D.F.P. in myasthenia gravis and found on prolonged administration in one case there was a marked diminution of the prostigmine requirements (a fall from 2 to 0-2 mg. after 3 weeks of daily D.F.P.). Another case was able to perform muscular movements without undue fatigue after a course of D.F.P. alone. 

Pain, muscular weakness, cramps and ease of fatigue are the most usual symptoms of muscular disease. In most cases, it is diseases of the vascular or nervous system or problems with the processes providing energy within the muscle that are responsible for clinical problems with muscles. Other clinical problems include the muscular dystrophies, myotonic disorders, inflammatory myopathies and disorders of neuromuscular transmission (see Walton, 1996). The best known is Duchenne muscular dystrophy. 

Thiamine (vitamin Bi), in the form of thiamine diphosphate (TPP), is a coenzyme of some considerable importance in carbohydrate metabolism. Dietary deficiency leads to the condition beriberi, characterized by neurological disorders, loss of appetite, fatigue, and muscular weakness. We shall study a number of... 

In humans, the onset of symptoms may be delayed for up to 24 hours. Minor intoxication causes lethargy, confusion, fatigue, inability to concentrate, headache, and feelings of constriction of the chest. With moderate intoxication, effects are more obvious and include thick speech confused, sleepy appearance transient nystagmus and drooping of the eyelids and euphoria. With severe intoxication, there are signs of muscular incoordination tremor and tonic spasms of the muscles of the face, neck, abdomen, and extremities and convulsions and opisthotonos. ... 

Exposure to extremely high concentrations of toluene (5000-30,OOOppm) may cause mental confusion, loss of coordination, and unconsciouness within a few minutes. Controlled exposure of human subjects to 2 00 ppm for 8 hours produced mild fatigue, weakness, confusion, lacrimation, and paresthesias of the skin. At 600 ppm for 8 hours other effects included euphoria, headache, dizziness, dilated pupils, and nausea. At 800 ppm for 8 hours, symptoms were more pronounced and aftereffects included nervousness, muscular fatigue, and insomnia persisting for several days. " ... 

Workers exposed to average levels of TCE estimated to be 100-2 00 ppm have reported increased incidence of fatigue, vertigo, dizziness, headaches, memory loss, and impaired ability to concentrate. Other effects noted at about 100 ppm and above include paresthesia, muscular pains, and gastrointestinal disturbances. 

Hyperkalemia AmWonde may cause hyperkalemia (serum potassium greater than 5.5 mEq/L) that, if uncorrected, is potentially fatal. Monitor serum potassium carefully. Symptoms of hyperkalemia include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia, shock, and EGG abnormalities. 

During withdrawal, some patients may experience symptoms of steroid withdrawal (eg, joint or muscular pain, lassitude, depression) despite maintenance or even improvement of respiratory function. Encourage continuance with the inhaler, but observe for objective signs of adrenal insufficiency (eg, fatigue, lassitude, weakness, nausea and vomiting, hypotension). If adrenal insufficiency occurs, increase the systemic steroid dose temporarily and continue further withdrawal more slowly. During periods of stress or severe asthma attack, transfer patients will require supplementary systemic steroids. 

Dizziness and nausea, possibly progressing to vomiting Blurred vision, impaired accommodation Muscular weakness and/or malaise, fatigue, etc. Gastrointestinal distress Paresthesia and/or anesthesia Rash... 

ACh receptors are destroyed by endocytosis via coated pits and proteolysis in lysosomes. In myasthenia gravis, the receptors are crosslinked by antireceptor antibodies, which facilitate the rate-limiting endocytosis step receptor destmction occurs in less than half the normal time, resulting in net receptor loss. The chronic disease is characterized clinically by such muscular weakness and abnormal fatigue that patients cannot even keep their eyes open. Acetylcholinesterase inhibitors increase the ACh concentration and excitation of the neuromuscular junction, resulting in increased strength and endurance. As expected, AChE inhibitors are also potent curare antidotes because the increased ACh levels displace the blocker more readily. 

Neostigmine is a drug of choice in the treatment of myasthenia gravis, a chronic disease characterized by muscular weakness and rapid fatiguability of the skeletal muscles due to impaired neuromuscular transmission. The defect may be presynaptic or postsynaptic. 

The primary signs and symptoms of all types of heart failure include tachycardia, decreased exercise tolerance, shortness of breath, peripheral and pulmonary edema, and cardiomegaly. Decreased exercise tolerance with rapid muscular fatigue is the major direct consequence of diminished cardiac output. The other manifestations result from the attempts by the body to compensate for the intrinsic cardiac defect. 

Nicotinic signs and symptoms result from the accumulation of acetylcholine at motor nerve endings in skeletal muscle and autonomic ganglia. Thus, there is fatigue, involuntary twitching, and muscular weakness, which may affect the muscles of respiration. Hypertension and hyperglycemia may also reflect the action of acetylcholine at sympathetic ganglia. 

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