Muscular twitching

Tetany Hyperexcitability of nerves and muscles characterized by muscular twitching and cramps, laryngospasm with inspiratory stridor, and hyperreflexia. 

This material is hazardous through inhalation and penetration through broken skin. Causes immediate pain in contact with any break in the skin. General symptoms include hyperexcitability, restlessness, salivation, lacrimation, accelerated respiration, convulsions, contractions, and muscular twitching, followed by spastic paralysis with rigid limbs. Death is due to respiratory failure and can occur within a few minutes or be delayed for several hours. 

Skin Contact Don respiratory protective mask and remove contaminated clothing. Immediately wash contaminated skin with copious amounts of soap and water, 10 percent sodium carbonate solution, or 5 percent liquid household bleach. Rinse well with water to remove excess decontaminant. Administer Nerve Agent Antidote Kit, Mark I, only if local sweating and muscular twitching symptoms are observed. Seek medical attention immediately. 

Easy fatigue, mild weakness, muscular twitching, fasciculations, cramps, generalized weakness, including muscles of respiration, with dyspnea and cyanosis. 

Liquid Local Skin Local sweating and muscular twitching 3 min. to 2 hours... 

Some of the early symptoms of a percutaneous exposure may be local muscular twitching or sweating at the area of exposure followed by nausea or vomiting. 

In view of the greater toxicity often observed with derivatives of o-cresol compared with derivatives of phenol itself, it seemed worth while to prepare di-(o-methylcycZohexyl) phosphoro-fluoridate. At a concentration of 0-65 mg./l. only three out of a batch of twenty-three animals (rabbits, guinea-pigs, rats and mice) were killed. The animals which died (the rabbits) exhibited muscular twitchings, but myosis was not very marked. 

F (muscular twitches and fibrillations, ataxia salivation, urination, defecation,... 

In rats, when dichlorodifluoromethane was administered at various concentrations with 20% oxygen for 30 minutes, the following effects were observed 2 00,000 ppm, no observable effects 300,000ppm, muscular twitching and tremor 800,000 ppm, coma, corneal reflexes absent 800,000 ppm for 4 and 6 hours was not lethal and the animals suffered no permanent effects. In a recent report 3- to 20-minute exposure of rats to concentrations of 140,000-470,000 ppm induced in a dose-dependent manner acute neurobehavioral effects ranging from operant performance deficits, to motor and equilibrium deficits, to anesthesia with occasional convulsions. ... 

A chemical worker accidentally exposed to an unknown concentration of the vapor developed giddiness, diarrhea, sleepiness, and irritability, with recovery in a week when reexposed 3 months later, he experienced drowsiness, vomiting, pallor, incoordination, slurred speech, muscular twitching, oliguria, coma, and death. At autopsy there were bronchopneumonia and pulmonary hemorrhages, with accumulation of combined iodine in the brain. 

SYMPTOMS - Dim vision, pinpoint pupils (may not occur from skin absorption), runny nose, tightness of chest, sweating, muscular twitching nausea, vomiting, weakness and coma. Vapor inhalation or absorption of vapor through the eyes causes quickest onset of symptoms. Skin absorption generally takes about 10 minutes. 

If higher concentrations are introduced into thebloodstream, depression of cardiac excitability and contractility may cause AV block, ventricular arrhythmias, or cardiac arrest. CNS toxicity including dizziness, tongue numbness, visual impairment and disturbances, and muscular twitching appear to occur before cardiotoxic effects. 

All local anesthetics have the ability to produce sleepiness, light-headedness, visual and auditory disturbances, and restlessness when high plasma concentrations are produced after rapid absorption or inadvertent intravascular administration. An early symptom of local anesthetic toxicity is circumoral and tongue numbness and a metallic taste. At higher concentrations, nystagmus and muscular twitching occur, followed by tonic-clonic convulsions. Local anesthetics... 

The mechanism of muscular twitching and convulsions under the influence of 1-phenylsilatrane was studied on isolated rectal abdominal muscles of frogs. The compound used at 10 s M concentration does not cause contraction of the muscle. 

In experiments with decerebrated cats the spasm and respiratory stimulation were observed immediately after administration of 1-phenylsilatrane. The preliminary pharmacological denervation of the sinocarotid regions with 0.5% novocaine solution (5 ml) did not affect the respiratory stimulation. Spinal cats displayed spasmodic muscular twitching after administration of 1-phenylsilatrane at higher doses. 

After intravenous injection of a fatal dose of NG in rabbits, immediate respiratory stimulation was observed, closely followed by slowing of the heartbeat, muscular twitchings and convulsions. Between convulsions, the heart rate was accelerated and the respiratory rate decreased the animals died of respiratory paralysis. The toxicological picture of NG poisoning is similar to that of asphyxiation, due either to the fall in blood pressure or methemoglobinemia. Despite similarities to Na nitrite poisoning, the toxic effects of NG cannot be explained solely on the basis of its nitrite action... 

Moderately severe OPP poisoning may include all of the above symptoms plus chest discomfort (tightness, wheezing), a productive cough, pulmonary edema, a marked constriction of the pupils (miosis) muscular twitching, and the inability to walk. These symptoms could be mistaken for encephalitis, myocardial infarction and pneumonia. 

Inhalation of vapor may cause dizziness, drowsiness, mental confusion, muscular twitching, and delirium. The vapor and liquid irritate the eyes and distort the vision. The liquid irritates the skin and may cause blistering. The liquid must be assumed to be an irritant and poisonous if taken by mouth. Avoid breathing vapor. Prevent contact with skin and eyes.4 An experimental neoplastic.5 TLV-TWA 2 ppm (12 mg/m3) (skin).6... 

Ethion Discomfort, vomiting, muscular twitching, nausea, nervousness convulsions... 

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