Fatigue, depression

The most common adverse reactions include nausea, vomiting, diarrhea, headache, and insomnia. The drug may also cause fatigue, depression, nervousness, and... 

Carvedilol 3.125 mg twice 25 mg twice (50 mg twice for patients greater than 85 kg or 1 87 lbs) each dose titration, ECG Adverse effects worsening HF symptoms (edema, SOB, fatigue), depression, sexual dysfunction... 

Flulike symptoms fever, chills, myalgias fatigue depression insomnia thrombocytopenia... 

An epidemiological study tested the effects of chronic exposure to jet fuel in factory workers (Knave et al. 1978). This study found significant increases in neurasthenia (i.e., fatigue, depressed mood, lack of initiative, dizziness, and sleep disturbances) in the exposed subjects when compared to unexposed controls from the same factory. Also, attention and sensorimotor speed were impaired in the exposed workers, but... 

In one case study, anorexia was reported in a man who washed his hands with diesel fuel over several weeks (Crisp et al. 1979). Effects resulting from inhalation versus dermal exposure could not be distinguished in this case. An epidemiological study found a significant increase in neurasthenia (i.e., fatigue, depressed mood, lack of initiative, dizziness, and sleep disturbances) in workers who were chronically exposed to jet fuels by either inhalation, oral, and/or dermal exposure (Knave et al. 1978). Also, attention and sensorimotor speed were impaired in the exposed workers, but no effects were found on memory function or manual dexterity. Results of EEG tests suggest that the exposed workers may have instability in the thalamocortical system. The limitations of the study were discussed in detail in Section 2.2.1.2 under Respiratory Effects. 

A number of effects have been associated with chronic exposure to jet fuel in factory workers (Knave et al. 1978). These effects included increases in the occurrence of neurasthenia (anxiety and/or mental depression, fatigue, depressed mood, lack of initiative, dizziness, palpitations, thoracic oppression, sleep disturbances) and eye irritation. Psychological tests found that attention and sensorimotor speed were impaired in exposed workers, but there were no effects on memory functions or manual dexterity. EEG tests suggested that there may have been instability in the thalamocortical system in the exposed group. However, the type of jet fuels were not noted nor was there a control for exposure to other compounds. Inhalation exposure is likely since jet fuel vapor was detected by the study authors however, dermal and oral (i.e., eating with contaminated hands) exposures may also be possible. 

Of particular importance in the geriatric patient Due to systemic absorption bradycardia, hypotension, dizziness, fatigue, depression, anxiety, hallucinations, broncho-spasm, impotence due to topical administration stinging, tearing, blurred vision, light sensitivity/photophobia, dryness, decreased visual acuity... 

Dizziness, dry eyes, fatigue, depression, edema, hypertension, upper abdominal pain, vomiting, urine retention, delirium... 

A 44-year-old man with an initial TSH concentration within the reference range took thalidomide 400 mg/ day for multiple myeloma and within 4 weeks developed cold intolerance, fatigue, depression, dizziness, and bradycardia, and had a markedly raised TSH (1114). He was given levothyroxine and the dose of thalidomide was reduced to 200 mg/day, after which he became euthyroid. 

Fatigue, depression of all sensations, faulty judgment, emotional instability in later phases, nausea, vomiting, prostration, unconsciousness, convulsions, coma, death... 

Heavy metals, like lead and mercury, have been recognized as toxic poisons for centuries. Further, toxic concentrations of mercury, for example, can trigger several effects like autoimmune diseases, infections, unexplained chronic fatigue, depression, nerve impairment, memory problems, decreased mental clarity, and bowel disorders. For several decades, mercury vapor exposure has caused severe health problems among chloralkali workers. This is only an example. It may be repeated that education can effectively minimize exposure to hazardous metals. Basic information and training for proper handling of toxic chemicals will reduce potential adverse health effects. 

In an epidemiological study reported by Knave et al. (1978), factory workers chronically exposed by inhalation, oral, and dermal routes to jet fuel (fuel type not reported) were found to have significant increases in conditions such as fatigue, depression, dizziness, and sleep disturbances. Also, the workers reported a significant increase in a feeling of heaviness in their chests. An estimated time-weighted average of 128-423 mg/m3 jet fuel was found in the work area. A limitation of this study is that other exposures were not considered. Factory workers chronically exposed by the dermal route to kerosene for up to 5 hr/d exhibited dermatosis and erythema (Jee et al. 1985). The concentration of kerosene was not reported. 

Sedation, fatigue, depression Dizziness, ataxia, slurred speech, weakness... 

Muscle cramps, fatigue, depression, abnormal dreams... 

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