Massive pulmonary thromboembolism

Acute massive pulmonary thromboembolism has been attributed to olanzapine in two patients (60) ... 

Kamijo Y, Soma K, Nagai T, Kurihara K, Ohwada T. Acute massive pulmonary thromboembolism associated with risperidone and conventional phenothiazines. Circ J 2003 67 46-8. 

Woo KS, Tse LK, Woo JL, Vallance-Owen J. Massive pulmonary thromboembolism after antifibrinolytic therapy. Ann Emerg Med 1989 18(1) 116-17. 

Massive pulmonary thromboembolism was reported in a 62-year-old woman 7 days after treatment with high doses for subarachnoid hemorrhage (43). 

Observational studies In a multicenter, observational retrospective review of 127 patients (80 male, mean age 51.7years) who had undergone at least ISmonths of treatment with alpha-l-antitrypsin therapy (Trypsone or Pro-lastin ), there were four serious adverse events that occurred during the treatment period one massive pulmonary thromboembolism, one myeloid leukaemia, one acute myocardial infarction and one haemorrhagic infarcHon but were judged not to be related to treatment. Seven of 11 nonserious adverse events were considered related to treatment including mild to moderate cutaneous symptoms (facial erythema, oedema/pruritus, rash), chills, fever and anxiety [31 ]. 

In a study of the combination of thahdomide 100 mg/day with darbepoetin aha 2.25 mg/kg/day in patients with myelodysplastic syndromes, there was an unexpectedly high incidence of thromboembohc events (194). Of the first seven patients emolled, two developed deep vein thromboses and one died of a massive pulmonary embolus. The authors concluded that thalidomide may increase the thromboembolic risk associated with erythropoietic proteins in patients with myelodysplastic syndromes. 

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