Existing chemicals registration

In what is being called the most far-reaching overhaul of European Union environmental policy ever, the European Commission released a draft policy proposal on May 7 that, if enacted, would require virtually all manufacturers of chemicals to provide risk assessments and other information regarding products they sell or ship into the EU. Chemicals would also have to be registered with the EC and many downstream users of products that contain chemical entities would have to file paperwork as well. The Registration, Evaluation and Authorisation of Chemicals, or REACH, proposal would apply to approximately 30,000 new and existing chemicals, and test data would have to be developed on some 5000 specific chemical entities, many of which have been commonly used for decades. EUROPEAN COMMISSION... 

The Registration, Evaluation, Authorisation and Restriction of Chemical substances (REACH) regulations came into force on June 1, 2007. At that time, it was estimated that there were approximately 100,000 existing chemicals, of which approximately 30,000 were marketed in volumes at or above 1 tonne per year. For these 30,000 substances, a registration dossier must be submitted. The registration requirements depend on the tonnage thresholds, as follows ... 

National Registration Authority for Agriculture and Veterinary Chemicals of Australia (November 1999). The NRA review of atrazine existing chemical review program. 

National Registration Authority for Agricultural and Veterinary Chemicals, Existing Chemicals Review (1997). The NRA Review of Atrazine, November. Canberra, Australia. 

For example, once implemented, the European Commission s new chemicals policy REACH (Registration, Evaluation and Authorization of Chemicals) -endorsed in 2003 - would require manufacturers and importers of over one ton per year of any chemical substance to gather information on the properties, hazards, and use of that substance, and submit the data to the European Chemicals Agency. The Agency would then determine if the chemical substance needed to be further regulated, restricted, or banned from use. It is estimated that about 30,000 existing chemicals produced in or imported into Europe would be subject to REACH. Key objectives of the European Commission s initiative on the reformulation of chemicals policy are to raise human and environmental safety levels as well as to simplify and standardize the current legislation. 

A chemical registration component of an enterprise screening informatics environment must also allow for rapid and economical correction of erroneous structures. Processes to facilitate error correction must be developed during system design and deployment. Even if a structure is identified as incorrect (e.g., by HPLC-MS) after it is associated with screening data endpoints, easy correction must be possible. The situation becomes more complicated if the (corrected) structure already exists in a database under another ID. In that situation it may be impractical to change the structure ID in all data tables of the operational system and it is not necessary. 

In order to fill the data gaps for existing chemicals the corresponding regulation has been revised in the European Union aiming at a nearly equal treatment of new and existing chemicals under the acronym REACH = Registration, Evaluation and Authorization of Chemicals [37]. 

A second issue, which has been controversial, involves registration of certain multi-constituent substances. Directive 67/548/EEC regulated the placing of substances on the market, which meant that a multi-constituent substance was covered by the European Inventory of Existing Chemical Substances (EINECS) if all the individual constituents were listed. Therefore, if A reacts with B to... 

In the European Union (EU), Registration, Evaluation, Autorisation and Restriction of Chemicals (REACH) resolves the dilemma faced under the TSCA to some degree because there is no distinction between new and existing chemicals. Simultaneously, significant new nomenclature issues will undoubtedly surface. Under the Sixth Amendment to the Dangerous Substances Directive, the European Inventory of Existing Chemical Substances (EINECS) was established as the inventory of chemical substances that were manufactured in or imported into the EU at the time that it was established. EINECS consisted of those chemicals being in commerce in the... 

The Chemical Registration Center of the State Environmental Protection Administration (CRC-SEPA, later the Chemical Registration Center of the Ministry of Environmental Protection, MEP) began to inventory existing chemical substances manufactured in or imported into the People s Republic of China in 1992. The first edition of the Inventory of Existing Chemical Substances in China (lECSC) included chemical substances that were manufactured, processed, or used inside China, or imported from outside China for commercial purposes during the period from January 1, 1992 to December 31, 1994 [124]. CRC-SEPA stated the purpose of the inventory as follows [124, p. 3] ... 

Chemical Registration Center of State Environmental Protection Administration. 2004. Technical Document on Reporting for the Inventory of Existing Chemical Substances in China. Available at http //www.crc-mep.org.cn/newchem/ebcsl. htm (accessed March 15,2014). 

On June 1, 2007, the European Community put into force a new regulation called Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Although it specifically applies to manufacturers within the European Union and manufacturers that import into the EU, it is becoming the de facto worldwide standard for regulation of chemical products. All firms that handle one metric tonne or more per year of any chemical product or produce any chemical product that is new to commerce are covered. For many existing chemical products, new data will need to be measured to determine hazards more accurately. Details of the regulation are available at http //echa.europa.eu. 

Compound Registration. A common step in a chemical synthesis experiment is the reaction of one or more existing molecules to form a desired product. This necessitates selecting molecules from a chemical database or repository and registering the target molecule into that same chemical database or... 

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