EPA registration requirements

Finally, to avoid the parallel use of similar but not identical method validation studies to fulfil the registration requirements, e.g., of the EU, US Environmental Protection Agency (EPA) or Japanese authorities, an adaptation of different data requirements for residue analytical methods for post-registration control and monitoring purposes would help to save resources. 

The registrant may submit residue data on any number of processed fractions. Table 1 of the 860 Series just defines what the EPA is required. A registrant may be wise to take a proactive approach and collect residue data on additional processed commodities for use in dietary exposure assessments. 

A final document was produced in mid-1986. The guidelines were modeled after FDA, EPA and OECD GLP regulations for animal studies. The document addressed residue (laboratory and field), metabolism (plant and animal), and environmental chemistry studies done for FIFRA registration requirements. This paper will not go into detail... 

United States, a major research programme was initiated in 1990 by a consortium of about 39 chemical companies, the Spray Drift Task Force (SDTF). The SDTF which was formed to support spray-drift registration requirements for the US Environment Protection Agency (EPA), conducted an extensive trial programme consisting of some 300 experimental applications. 

The least costly and, ultimately, most effective approach toward solving this problem is preventative. At the federal level, EPA must develop more rigorous pesticide registration requirements. Pesticides with a high potential for leaching should not be registered for nematode control. Industry can play a lead role in... 

Although inert ingredients normally need not be separately identified, EPA may require registrants to list those inert ingredients that the agency determines may pose a hazard to man or the environment. 

Finally, all required text must be in English, although EPA may require or the registrant may propose text in other languages. When another language is used on a label, it will be subject to the same requirements as the English language version. 

Insecticide efficacy, the stability of active ingredients, and programmed release of active ingredients from the vehicle/devicc are the most important characteristics controlled for when pesticides are formulated (Krcnek and Rhode, 1988). Environmental Protection Agency (EPA) registration does not always require percutaneous absorp-... 

Single residue methods or SRMs, are used by FDA when no general or selective MRM is available. These methods are usually capable of determining the level and identity of the residue of only one pesticide from a limited number of commodities. SRMs are usually submitted during the registration process to meet EPA s requirement for an analytical method capable of determining compliance with the requested tolerance. 

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