Ethyl acetate fumaric acid

Acetic acid Acetaldehyde Acetone L-Alanine l-Alanine ion L-Alaninate ion L-Arginine dl-Aspartic acid L-Aspartic acid L-Aspartic acid ion L-Aspartate ion Benzene Butyric acid Butyrate ion Carbon dioxide Citric acid Citrate ion Creatine L-Cysteine L-Cystine Ethanol Ethyl acetate Formic acid Formate ion Fumaric acid Fumarate ion a-D-Glucose p-D-Glucose Glycerol L-Glutamic acid L-Glutamate ion... 

A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100 cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1-piperazinyl)-1 heated under reflux for 5 hours. After treatment of the reaction products, a crude oily base (2.5 g) is obtained after treatment. By the addition of a solution of fumaric acid in ethanol to an ethanolic solution of the base, 3-dimethylsulfamoyl-10-(3-4 -methyl-1 -piperazinylpropyD-phenthiazine diacid fumarate (2.6 g) is obtained, melting point 182°C. The base recrystallized from ethyl acetate melts at about 140°C. 

In addition, the use of enzyme selective inhibitors has turned out to be very effective. Reductions were performed by adding l,l,l-trifluoro-2,4-pentane-dione 1 to a yeast-water suspension with selected additives such as methylvinyl-ketone, allyl alcohol, alkanoic acids, ethyl chloroacetate or allyl bromide, all of them reported to affect the stereochemical course of baker s yeast reduction. In some cases, both the influence of the yeast/substrate ratio and the influence of the presence of glucose were considered. In the presence of alkanoic acids (acetic, fumaric, or oleic acid), no significant effect was observed. However, addition of methylvinyl-ketone, allyl alcohol, ethyl chloroacetate and allyl bromide to the reaction system affected the stereochemical course of the reduction of 1. In particular, (R)-(+)-2 was produced in the presence of ethyl chloroacetate and allyl bromide as additive. 

Fumaric and L-malic acids D2EHPA/dichlormethane and TOPO/ethyl acetate Flat sheet [195]... 

A solution of 52.5 ml l-dimethylamino-2-chloroethane in 200 ml toluene is added at a temperature below 20°C the mixture is refluxed for 20 h and cooled, and 100 ml t-butanol are added. The mixture is agitated for 1 h at room temperature, 35 ml ethanol are added, and the mixture is again agitated for 30 min at room temperature. It is then extracted with 2 N hydrochloric acid the acidic phases are washed with ether, made alkaline by the addition of sodium hydroxide solution, and extracted with ether the ethereal phases are washed with water, dried over magnesium sulphate and then distilled to dryness under a vacuum. The residue is dissolved in 100 ml methanol 300 ml of a saturated solution of fumaric acid in methanol are added the methanol is distilled off and replaced by ethyl acetate. Crystallization is allowed to commence and the mixture is cooled with ice for 30 min and suction-filtered the precipitate is washed with water and dried. 

Methyl-l-piperazinyl)benzimididazole (5.00 g) prepared as above is dissolved in N,N-dimethylformamide (50 ml) and thereto is added sodium hydride (concentration 50%) (1.50 g) at room temperature, and the mixture is stirred for 30 minutes. To the mixture is added 2-bromoethyl ethyl ether (4.00 g), and the mixture is stirred at 70°C for 10 hours. To the reaction mixture is added water (150 ml), and the mixture is extracted with ethyl acetate. The extract is washed with water, dried over anhydrous magnesium sulfate and then concentrated to give a brown oily substance (5.40 g). The brown oily substance is treated with fumaric acid (3.26 g) in hot ethanol. The crude crystals thus obtained are recrystallized from ethyl acetate-ethanol to give l-[2-(ethoxy)ethyl]-2-(4-methyl-l-piperazinyl)benzimidazole 3/2 fumarate (6.31 g) as colorless plates, melting point 167.5°-168.5°C. Elementary analysis for C22H30N4O7 Calcd. (%) C, 57.13 H, 6.54 N, 12.11 Found (%) C, 57.04 H, 6.44 N, 12.02. 

The amino benzopyran of step 5 (2.0 g) and dimethyl acetylene dicarboxylate (1.24 g 1.01 ml) were refluxed in ethanol (30 ml) for 26 hours. The reaction mixture was cooled to 0°C and the insoluble yellow-brown solid was collected by filtration and washed with a little ethanol and dried to give 2.0 g of a product which was a mixture of maleic and fumaric esters obtained by Michael addition of the amine to the acetylene. This mixture of esters (2.0 g) was treated with polyphosphoric acid (30 ml) and heated on the steam bath with stirring for 20 minutes. The reaction mixture was then poured onto ice and stirred with ethyl acetate. The organic layer was separated, washed with water and dried. The solvent was evaporated to leave 1.6 g of a yellow orange solid. Recrystallisation of this solid from ethyl acetate gave the required product as fluffy orange needles, mp 187°-188°C. 

A solution of the above compound in a mixture of ethanol (20 ml) and acetic acid (20 ml) is shaken with a 30% palladium-on-charcoal catalyst (0.1 g) in an atmosphere of hydrogen at laboratory temperature and pressure until 250 ml of hydrogen is absorbed. The mixture is filtered, the filtrate is evaporated to dryness under reduced pressure and to the residue is added a hot solution of fumaric acid (1.25 g) in ethanol (15 ml). The mixture is kept at 5°C for 12 hours and is then filtered, and the solid residue is washed with hot ethanol and then dried. There is thus obtained l-p-hydroxyphenoxy-3-beta-(morpholinocarbonamido)ethyl-amino-2-propanol hydrogen fumarate, m.p. 168-169°C (with decomposition). 

Ethylene distearamide , EthyleneA/A copolymer 2-Ethylhexanol Ferrous ammonium sulfate Fumaric acid Glyceryl acetate Glyceryl diacetate Hydrogenated castor oil Hydroxyethylcellulose Hydroxypropylcellulose Isopropyl acetate Isopropyl alcohol Itaconic acid Lanolin Lauryl alcohol Magnesium lauryl sulfate Magnesium myristate Magnesium palmitate Maleic acid Melamine-formaldehyde resin Methyl ethyl ketone ... 

Coriander (Coriandrum sativum) oil Cupric sulfate anhydrous Dehydroacetic acid Dimethyl dicarbonate Disodium EDTA Edetic acid Erythorbic acid Ethyl vanillate Ferulic acid Formic acid Fructose Fumaric acid Glucose oxidase Guaiac gum Heptyl paraben Hexamethylenetetramine 4-Hydroxymethyl-2,6-di-t-butylphenol Isobutylparaben Isopropyl citrate Isopropylparaben Lactic acid Methyl paraben Myristalkonium chloride Natamycin Nisin o-Phenylphenol Potassium acetate Potassium bisulfite Potassium butyl paraben Potassium diacetate... 

The addition of active methylene compounds (ethyl malonate, ethyl aoeto-acetate, ethyl plienylacetate, nltromethane, acrylonitrile, etc.) to the aP-double bond of a conjugated unsaturated ketone, ester or nitrile In the presence of a basic catalyst (sodium ethoxide, piperidine, diethylamiiie, etc.) is known as the Michael reaction or Michael addition. The reaction may be illustrated by the addition of ethyl malonate to ethyl fumarate in the presence of sodium ethoxide hydrolysis and decarboxylation of the addendum (ethyl propane-1 1 2 3-tetracarboxylate) yields trlcarballylic acid ... 

From the reaction with dimethyl fumarate, the 1 1 cycloadduct 471 was also isolated. On oxidation with 2,3,5,6-dichlorodicyanobenzoquinone in boiling dioxane, dihydropyrrolo[l,2-fl]quinazoline-l-carboxylate (473) afforded the pyrrolo(l,2-a]quinazoline-l-carboxylate 474. The latter product also resulted when the acid 475 was treated with an excess of ethyl propiolate and acetic anhydride in boiling xylene. The reaction of the thiazo[3,2-c]quinazoline 469 with dimethyl acetylenedicarboxylate in boiling toluene led to the pyrimido[l,2-a]quinazolinone 472. 

Geissman and Waiss (i<3 )have effected the first stereospecific synthesis of retronecine (CXLIV in 1) by a series of reactions which is shown in Chart I. Ethyl A-carbethoxy-3-aminopropionate (LI) was added to diethyl fumarate and the product ring-closed to the pyrrolidone, LII, which on hydrolysis and reduction yielded the required 3-hydroxy-pyrrolidine-2-acetic acid lactone (LIII). Reaction of this lactone with ethyl bromoacetate gave the A-acetic ester, LIV which by ring closure... 

Methyl benzoate Phenyl acetate Phenethyl alcohol 2,4-Xylenol m-Dimethoxybenzene Veratrole Dimethylaniline Ethylaniline Ethyl fumarate Ethyl maleate 2-Ethylcaproic acid Isoamyl lactate Octyl alcohol cc-Octyl alcohol Bis(2-ethoxyethyl) ether Indene... 

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