Ethyl-2- acetic acid

S-Chloro-a-methyl-l, 3,4-tetrahydrocarbazole-2-acetic acid ethyl ester... 

A stirred mixture of 11 g of 6-chloro-a-methylcarbazole-2-acetic acid ethyl ester, 100 ml ethanol and 100 ml of 3N sodium hydroxide was heated (N2 atmosphere). After 2 hours at reflux, the reaction mixture was concentrated to dryness under reduced pressure. Water (300 ml) and ice (200 g) were added to the residue and concentrated hydrochloric acid was added until the mixture was strongly acid. The acidic mixture was extracted with ether (3 X 200 ml). The ether extracts were combined, washed by extraction with water (3 x 100 ml) and dried over anhydrous magnesium sulfate. Following filtration of the desiccant and evaporation of the solvent, a yield of 9.8 g (98.2%) was obtained. Crystallization from CHCI3 yielded 6.2 g (62.0%) of 6-chloro-0 -methylcarbazole-2-acetic acid, MP 197°-198°C. A second crop of 1.6g,MP 195°-199°C was obtained from the mother liquors. 

A mixture of 34.9 g of 6-chloro-a-methyl-l,2,3,4-tetrahydrocarbazole-2-acetic acid ethyl ester (mixture of diastereomers), 350 ml CP xylene and 56.0 g of p-chloranil was stirred and heated under an atmosphere of dry nitrogen. The reaction flask was wrapped in aluminum foil in order to keep out any extraneous light. After the reaction mixture had stirred at reflux temperature for 6 hours, heating and stirring were stopped and the reaction mixture was left overnight at room temperature. The supernatant liquid was decanted... 

N-Methyl-N,N-dioctyl-1-octanaminium chloride. See Tricaprylyl methyl ammonium chloride 8-Methyl-3,6-dioxa-1-undecanol. See Diethylene glycol methylpentyl ether 2-Methyl-1,3-dioxolane-2-acetic acid ethyl ester. See Ethyl acetoacetate ethylene ketal 4-Methyl-1,3-dioxolan-2-one. See Propylene carbonate... 

C14H14 02 naphthalene-2-acetic acid ethyl ester 2876-70-2... 

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