Equipment cleaning agent

Portable Equipment. Chemical shoreline cleaning agents enhance removal of stranded oil from shoreline surfaces, but site-specific variables, physical and chemical properties of oil, and variations in substrate types influence the performance of shoreline cleaning agents. It is difficult to predict the performance for site-specific variables. Therefore on-site testing of shoreline cleaning agents with oil and local substrates is needed. 

Volatile organic compounds (VOCs) cleaning agents, cosmetics, waxes, carpels and paints building and furnishing materials office equipments like laser printers and photocopiers. irritation neurotoxic effects hepatotoxic carciogenic... 

Clean agent systems can also be used for explosion prevention and suppression where flammable materials are confined. Clean agent fire extinguishing systems are used primarily to protect hazards that are in enclosures or equipment enclosures. Some typical hazards that could be protected by clean agents are ... 

An appropriate number, type, and size of hand-held fire extinguishers should be provided throughout the building to handle ordinary combustibles and electrical fires in the control room and related areas. Typically, clean agent or carbon dioxide fire extinguishers should be provided for electrical and electronic equipment. Dry chemical extinguishers should be avoided because of equipment contamination with powder. For use on ordinary combustible fires in the associated areas water or multipurpose dry chemical fire extinguishers should be provided. 

Uses. Solvent for cleaning electronic equipment and degreasing of machinery refrigerant dry cleaning agent... 

The cleaning validation is required to demonstrate that, after cleaning, the equipment and surfaces are essentially free from product residues and traces of cleaning agents to prevent cross-contamination. 

Offline passivation involves treatment of equipment currently out of service. Treatment levels are typically higher consequently, passivation is completed more quickly. Passivation of nonchromate treatment generally uses either a polyphosphate, zinc, molybdate or other nonchromate-based inhibitor in combination with various surface-active cleaning agents. The passivation solution should be disposed of after the pretreatment stage, rather than dumped back into the cooling system where the potential for fouling can exist due to the precipitation of pretreatment compounds such as zinc or phosphate. Table 8.1 outlines both online and offline pretreatment procedures. 

Analytical methodology—This section should refer to the specific analytical method(s) to be used for the specific products, cleaning agents, and equipment for the protocol being evaluated. Many companies choose to have the detailed analytical methodology described in a separate report and reference only the report number in the actual protocol. There are certain parameters that should be included in the actual protocol, however. For example, the sensitivity of the analytical method, expressed either as the LOD or LOQ, should be included in the protocol since it will be necessary that the sensitivity of the analytical method be below the acceptance criteria for the residues so that a result of none detected can be interpreted, ft must be remembered that none detected does not mean that there was no residue present, but only that the level of residue was below the limit of detection of the analytical method. 

Chemical effect this is the influence of the chemicals in the detergents, cleaning agents or acids used. The concentration of these chemicals depends on the degree of equipment contamination. 

Check that the equipment was cleaned properly following previous processing and that acceptable cleanliness was indicated by rinse and/or swab sample results. Ensure that all cleaning agents (e.g., detergents) have been removed from surfaces of the equipment. 

Based upon the advantages of the other techniques presented prior to LC-MS, large volume injection HPLC-UV, and HPLC-CAD, the decision to use electrochemical detection would be driven primarily by a unique analytical need, equipment availability and previous experience of the analytical chemist. A complex chemical matrix should not be of concern at most there could be some residual cleaning agent and residual excipients in addition to the active pharmaceutical ingredient. Since the matrix in cleaning verification is typically simple, electrochemical detection would not be the primary detection technique. However, the sensitivity afforded by ECD is excellent and can meet the most stringent of the acceptance limits outlined in Table 15.2. 

Caution All equipment must be scrupulously clean (for an acceptable cleaning procedure, see AOCS Official Method Cd 12-57). Do not use chromic acid or other acidic cleaning agents. All receptacles in the heater must be calibrated for temperature under the exact conditions of the test. During the test, the temperature must be monitored in a sample tube containing the recommended quantity of oil. 

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