Enterococcus faecalis infection resistance

Daptomycin has proven efficacy in a number of in vivo animal models, including soft tissue infections by MRSA, bacteraemia caused by S. aureus or vancomycin-resistant enterococci (VRE), Enterococcus faecalis pyelonephritis, MRSA osteomyelitis, MRSA and Bacillus anthracis pulmonary infections, Gram-positive endocarditis, Clostridium difficile colitis and S. pneumoniae and S. aureus meningitis.9,64 66... 

A 53-year-old white woman with liver cirrhosis took vancomycin (1 g bd) for sepsis due to methicillin-resistant S. aureus and a catheter-associated infection due to Enterococcus faecalis, developed oral and vaginal mucositis and conjunctivitis followed by a macu-lopapular rash (69). The diagnosis was confirmed by skin biopsy. Vancomycin was replaced by teicoplanin and corticosteroids the symptoms disappeared within 7 days. 

Wells VD, Wong ES, Murray BE, et al. Infections due to beta-lactamase-producing, high-level gentamicin-resistant Enterococcus faecalis. Ann Intern Med 1992 116 285-292. 

Aarestrup FM, Agerso Y, Gemer-Smidt P, Madsen M, Jensen LB (2000) Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis wnd Enterococcus faecium from humans in the community, broilers, and pigs in Denmark. Diagn Microbiol Infect Dis... 

Chiew YF, Hall LM (1998) Comparison of three methods for the molecular typing of Singapore isolates of enterococci with high-level aminoglycoside resistances. J Hosp Infect 38 223-230 Clewell DB (1993) Bacterial sex pheromone-induced plasmid transfer. Cell 73 9-12 Coburn PS, Gilmore MS (2003) The Enterococcus faecalis cytolysin a novel toxin active against eukaryotic and prokaryotic cells. Cell Microbiol 5 661-669... 

Like the battle against viruses, the war to stop bacterial and parasitic infections has reached the critical stage, with multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE), killing thousands of people annually in the United States [196]. Likewise, tuberculosis (TB) has killed about 1 billion people worldwide over the past two centuries. Some 3.5 milUon people in India are currently infected with TB [197]. 

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