Prevotella intermedia

Bacteroides fragilis Prevotella intermedia Enterococcus faecalis A Enterococcus faecalis B... 

Takahashi, N., Saito, K., Schachtele, C.-F., and Yamada, T. 1997. Acid tolerance and acid-neutralizing activity of Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. Oral Microbiology and Immunology 12 323-328. 

Brenn et al. [ 153] compared the efficacy of antibiotics commonly used in dental and oral clinical practice in application to the bacteria most frequently isolated in odontogenic infections (S. viridans, Peptostreptococcus spp, Prevotella intermedia, Porphyromona gingivalis and Fusobacterium nucleatum) based on pharmacokinetic and pharmacodynamic (PK/PD) analyses (effect of the human body upon the drug, reflected by the plasma concentration profile-pharmacokinetics, and the effect of the drug upon the body, as defined by the minimum inhibitory concentration, or MIC-pharmacodynamics). Antibiotics commonly used in dental practice, such as erythromycin, metronidazole or azithromycin, were found to be ineffective in apphcation in over 30% of the strains (39.1%, 50.5% and 33.2%, respectively) [154]. 

In the present study, tetracycline was selected because of its wide application, both locally and systemically, in the treatment of periodontal diseases. Tetracycline has been shown to be effective against many of the common periodontopathic bacteria, in particular, against Prevotella intermedia and Porphyromonas gingivalis [204-206]. In the current study, two commercially available bacterial strains were selected to meet the preliminary goal of whether the activity of antibiotics can be preserved after incorporation into preparations (Table 11.3)... 

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