Dioxin receptor

There is increasing interest in the relationship of the HS response to environmental toxicology. As induction of the HS response portends resistance to otherwise lethal stresses, many environmental hazards have the potential for inducing the HS response (Finnell et al., 1992). Activity of the dioxin receptor is affected by HS proteins (Nemoto et al., 1990 Pongratz et al., 1992) and it is likely that the HS... 

Pongratz, I., Mawn, G.G., Poellinger, L. (1992). Dual roles of the 90 kD heat shock protein hsp90 in modulating functional activities of the dioxin receptor. J. Biol. Chem. 267, 13728-13734. 

Stronkhurst, J., Leonards, P., and Murk, A.J. (2002). Using the dioxin receptor Calux in vitro assay to screen marine harhour sediments for a dioxin-hke mode of action. Environmental Toxicology and Chemistry 21, 2552-2561. 

AhR Aryl hydrocarbon receptor (also known as dioxin receptor)... 

Sunscreens and their degradation metabolites analyzed in this study are potential inducers of the oestrogen (ER) and aryl hydrocarbon receptors (AhR, also known as Dioxin Receptor). Ectopic activation of these pathways can cause severe damage to organisms and their ecosystem by altering reproduction, hormonal and/or circulatory systems [73-75] as well as they have been associated with carcinogenic and mutagenic effects [76-78]. 

FlahnME, KarchnerSI, Shapiro MA, Perera SA (1997) Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc Natl Acad Sci USA 94 13743-13748... 

Gomez-Duran A, Mulero-Navarro S, Chang X, Fernandez-Salguero PM LTBP-1 blockade in dioxin receptor-null mouse embryo fibroblasts decreases TGF-(5 activity role of extracellular proteases plasmin and elastase. J Cell Biochem 2006 97 380-392. 

Roberts BJ, Whitelaw ML (1999) Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathway.) Biol Chem 274 36351-36356... 

To maintain consistency of statistical analyses, an identical microtiter plate setup was used by all participants, and all samples were analyzed in an identical manner. Both raw data and pretreated data from analyzed samples were submitted to OpdenKamp Registration and Notifieation for statistical evaluation. Data pretreatment consisted of all necessary calculations to convert the luminosity readings as submitted by the participating laboratories to effective dioxin-receptor activity (pM 2,3,7,8-TCDD TEQ). In addition to the analysis results of the defined samples (phase 1), the cleaned sediment extracts (phase 2), and the complete sediments (phase 3), all participants also submitted the results of the complete 2,3,7,8-TCDD calibration curves for statistical evaluation. 

PBPK models for 2,3,7,8-TCDD are discussed below. The pharmacokinetic behavior of 2,3,7,8-TCDD, especially distribution, has been shown to be dose-dependent and involves protein binding and enzyme induction in hepatic tissue. Thus, terms describing these interactions have been included in the animal models described below. Furthermore, since induction of these dioxin-binding proteins is a process mediated by the interaction of a dioxin-receptor (the Ah receptor) complex with specific binding sites on DNA additional terms were included in the models. For a detailed explanation regarding the Ah receptor and its involvement in the mechanism of action of 2,3,7,8-TCDD and structurally related halogenated aromatic hydrocarbons, see Section 2.4.2. 

Berghard A, Gradin K, Pongratz I, et al. 1993. Cross-coupling of signal transduction pathways the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism. Mol Cell Biol 13 67-689. 

Coumailleau P, Poellinger L, Gustafsson J-A, et al. 1995. Definition of a minimal domain of the dioxin receptor that is associated with hsp90 and maintains wild type ligand binding affinity and specificity. J Biol Chem 270 25291-25300. 

Okino ST, Pendurthi UR, Tukey RH. 1992. Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse CYP1A1 and CYP1A2 genes by... 

Poellinger L, Cuthill S, Wihelmsson A. 1991. The dioxin receptor A signal-dependent gene regulatory protein [Abstract 13], Toxicologist 11 27. 

Pongratz I, Stromstedt P-E, Mason GGF, et al. 1991. Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment. J Biol Chem 266 16813-16817. 

Whitelaw M, Pongratz I, Gustafsson J-A, et al. 1993. Ligand-dependent recruitment of the Amt coregulator determines DNA recognition by the dioxin receptor. Mol Cell Biol 13 2504-2514. 

Dioxin, 2,3,7,8-tetrachlorodibenzo-dioxin Receptor implicated in endotoxic shock... 

Mimura J, Ema M, Sogawa K, Fujii-Kuriyama Y. Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev 1999 13 20-25. 

The aryl hydrocarbon receptor (ARH-R or dioxin receptor) is activated by xenobiotics such as 2,3,7,8-tetrachlorodibenzo-j6-dioxin with resultant adverse effects. The activated receptor binds to a xenobiotic-responsive element with the consequent activation of the transcription of particular genes. Cell cycle progression is inhibited by naturally occurring and synthetic flavonoids at concentrations at which they act as agonists of the ARH-R. 

Whereas three or more or//io-chlorines block rotation about the ring-connecting bond, congeners with none, or only one, or//io-chlorine can relatively easily achieve a planar configuration (colloquially referred to as coplanars ) and may behave as isosteres (compounds with similar shape, functionality, and polarity) to 2,3,7,8 — tetrachlorodibenzodioxin (TCDD). These bind significantly to the dioxin receptor, and meas-... 

Probst MR, Reisz-Porszasz S, Agbunag RV, Ong MS, Hankinson O. 1993. Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Molec. Pharmacol. 44 511-18... 

Denison MS, Phelan D, Winter MG, Zic-cardi MH. 1998. Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor. Toxicol. Appl. Pharmacol. 152 406-14... 

Bandiera S, Sawyer TW, Campbell MA, Fujita T, Safe S. Competitive binding to the cytosolic 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor Effects of structure on the affinities of substituted halogenated biphenyls—A QSAR analysis. Biochem Pharmacol 1983 32 3803-13. 

Kobayashi, S. Kitadai, M. Sameshima, K. Ishii, Y. Tanaka, A., A theoretical investigation of the conformation changing of dioxins in binding site of dioxin receptor model role of absolute hardness-electronegativity diagrams for biological activity. J. Mol. Struct. 1999, 475, 203-217... 

Mimura, J., K. Yamashita, K. Nakamura, M. Morita, T.N. Takagi, K. Nakao, M. Ema, K. Sogawa, M. Yasuda, M. Katsuki and Y. Fujii-Kuriyama. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells 2 645-654, 1997. 

Duncan, D.M., E.A. Burgess and I. Duncan. Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor. Genes Dev. 12 1290-1303, 1998. 

Hahn, M.E. and S.I. Karchner. Evolutionary conservation of the vertebrate Ah (dioxin) receptor amplification and sequencing of the PAS domain of a teleost Ah receptor cDNA. Biochem. J. 310 383-387, 1995. 

Lees, M.J. and M.L. Whitelaw. Multiple roles of ligand in transforming the dioxin receptor to an active basic helix—loop—helix/PAS transcription factor complex with the nuclear protein Amt. Mol. Cell. Biol. 19 5811-5822, 1999. 

Santiago-Josefat, B., E. Pozo-Guisado, S. Mulero-Navarro and P.M. Fernandez-Salguero. Proteasome inhibition induces nuclear translocation and transcriptional activation of the dioxin receptor in mouse embryo primary fibroblasts in the absence of xenobiotics. Mol. Cell. Biol. 21 1700-1709, 2001. 

Whitelaw, M., J.A. Gustafsson and L. Poellinger. Identification of transactivation and repression functions of the dioxin receptor and its basic helix—loop—helix/PAS partner factor ARNT inducible versus constitutive modes of regulation. Mol. Cell. Biol. 14 8343 -8355, 1994. 

Cuthill, S., A. Wilhelmsson, G.G. Mason, M. Gillner, L. Poellinger and J.A. Gustafsson. The dioxin receptor a comparison with the glucocorticoid receptor. J. Steroid Biochem. 30 277-280, 1988. 

Gradin, K., M.L. Whitelaw, R. Toftgard, L. Poellinger and A. Berghard. A tyrosine kinase-dependent pathway regulates ligand-dependent activation of the dioxin receptor in human keratinocytes. J. Biol. Chem. 269 23800-23807, 1994. 

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