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Effects on Epstein-Barr virus

The studies were carried out on a primary screening test using their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol- 13-acetate (TPA), a strong promoter, in Raji cells. [Pg.642]

Ajuga decumbens Inflammation Cough. Respiratory 8-O-acetylhaipagide Cancer chemopreventlve Strong inhibitory effects on Epstein-Barr virus early agniigen (EBV-EA) induction. [43]... [Pg.371]

The lupane triterpene, betulin (163) showed inhibitory effects on Epstein-Barr virus activation and bacteriostatic activities against Escherichia coli. Salmonella typhi, Shigella flexneri and Staphylococcus aureus. Antitumor activity was reported against human epidermoid... [Pg.706]

A test of inhibitory effects on Epstein-Barr virus early antigen activation in Raji cells induced by a combination of n-butylic acid and 12-0-tetradecanoylphorbol-13-acetate (TPA) has been employed (EBV-EA test) as a simple primary screening for antitumor promoting agents. In this test, significant inhibitory effect was observed for astilbin and its isomers as well as (+)-taxifolin. Of these dihydroflavonol derivatives, neoastilbin showed the strongest activity. [Pg.14]

Inhibitory Effects on Epstein-Barr virus Early Antigen Activation... [Pg.36]

Renouf B, Hollville E, Pujals A, Tetaud C, Garibal J, Wiels J. Activation of p53 by MDM2 antagonist has di f(raential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt s lymphoma cells. Leukemia. 2009 23 1557-63. [Pg.741]

Inhibitory effect on Epstein-Barr virus activation Methyleneoxy bridge and side chain enhance activity, sugar moiety-reduced activity [70]... [Pg.3351]

Z0346 Furukawa, M., H. Sakashita, M. Kamide, and R. Umeda. Inhibitory effects of Kampo medicine on Epstein-Barr virus antigen induction by tumor promotor. Auris-Nasus Larynx (Tokyo) 1990 17(1) 49-54. [Pg.560]

Slaughter, L., Carson, D. A., Jensen, F. C., Holbrook, T. L., and Vaughan, J. H., In vitro effects of Epstein-Barr virus on peripheral blood mononuclear cells from patients with rheumatoid arthritis and normal subjects. ]. Exp. Med. 148, 1429-1434 (1978). [Pg.56]

Kapadia GJ, Sharma SC, Tokuda H, Nishino H, Ueda S (1996) Inhibitory effect of iridoids on Epstein-Barr virus activation by a short-term in vitro assay for anti-tumor promoters. Cancer Lett 102 223-226... [Pg.3066]

Okano M, Fukamiya N, Tagahara K, Tokuda H, Iwashima A, Nishino H, Lee KH (1995) Inhibitory effects of quassinoids on Epstein-Barr virus activation. Cancer Lett 94 139-146... [Pg.3364]

Li+ has significant inhibitory effects upon DNA viruses, in particular HSV which has been studied in depth. It was originally shown that Li+ inhibits viral replication in a dose-dependent, reversible manner in HSV-infected baby hamster kidney cells [240], and this has been found to be due to a Li+-induced decrease in the synthesis of viral DNA [241]. It is now well established that Li+ inhibits DNA synthesis in HSV types 1 and 2 and in several other DNA viruses, including measles, vaccinia, adenovirus, poxvirus, pseudorabies virus, Epstein-Barr virus, and the bovine, equine, and canine HV s [241]. Interestingly, Li+ has no effect on the replication of RNA viruses, such as influenza or encephalomyo-carditis virus. [Pg.39]

Epstein-Barr virus early antigen induction. Methanol extract of the dried leaf, in cell culture at a concentration of 1 pg/mL, was inactive. The assay was designed for tumor-promoting activity . Two diastere-oisomers of 2,7,1 l-cembratriene-4,6-diol (a- and 3-CBT) from the neutral fractions of cigarette smoke condensate, in Raji cells, produced potent inhibitory effects on the induction of Epstein-Barr virus (EBV)-EA by 12-0-tetradecanoylphorbol-13-acetate (TPA). The doses of a- and P-CBT required for 50% inhibition of EBV-EA induction by TPA were 7.7 and 6.7 mg/mL, respectively. Application of a- and P-CBT to mouse skin before treatment with TPA, inhibited TPA-induced ornithine decarboxylase activity in a dose-dependent manner. Application of 16.5 pM/mouse of a- and p-CBT resulted... [Pg.308]

Soyasapogenol B, soyasaponins I and II and wistariasaponins from Wistaria brachybotrys (wistariasaponin C corresponds to astragaloside VIII) decreased (20-30%) the Epstein-Barr Virus (EBV) activation induced by the tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate) in Raji cells at a concentration of lxlO2 mol ratio [151]. Soyasaponin I from the same plant exhibited remarkable inhibitory effects on mouse skin tumor promotion on the basis of the two-stage DMBA-TPA carcinogenesis test in vivo. Soyasaponin I reduced the number of papillomas per mouse at about 40% even at 20 weeks [152]. [Pg.222]

Lin, J. C., Smith, M. C., and Pagano, J. S. (1982) Effects of 12-O-tetra-decanoyl-phorbol-13-acetate on cell proliferation and Epstein-Barr virus DNA replication. Virology 117, 186-194. [Pg.149]

Mar, E. C. and Lin, J. C. (1996) Effects of temporal treatments of nucleoside analogs on replication of Epstein-Barr virus. Ninth International Conference on Antiviral Research, Fukushima, Japan, May 19-24. [Pg.149]

Cl 1.7-12.0). Additional analysis indicated that the effect of PCBs on risk of NHL was increased among participants who were seropositive for Epstein-Barr virus early antigen. [Pg.296]

In a chapter Infection Unmasked, Drexler first underscores the point that some 70% of all deaths are due to lingering or chronic illnesses rather than to the abrupt severity of acute afflictions. Furthermore, there is the statement that today, a growing number of researchers claim that these disabling conditions may be caused by infection. Thus, more than 90% of cervical cancer cases are caused by the human papillomavirus, and more than 60% of liver cancer cases result from the hepatitis B virus. The retrovirus HTLV-1 is the precursor for adult T cell lymphoma, with the cancerous condition occurring decades after the infection. The Epstein-Barr virus, a herpes-type virus causing mononucleosis, also has an effect on people with malaria, producing a cancer known as Burkitt s lymphoma, the leading cause of childhood cancer deaths worldwide. Kaposi s sarcoma, known as a comphcation of AIDS, is said to be caused by human herpesvirus 8. [Pg.364]

R15. Richter, W., Eiermann, T. H., and Scherbaum, W. A. Effect of cytokines on proliferation of Epstein Barr virus-transformed B lymphocytes. Hybridoma 9, 1-8 (1990). [Pg.80]

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Epstein-Barr virus

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