Wistaria brachybotrys

Konoshima, T., M. Takasaki, M. Kozuka, H. Tokuda, H. Nishino, E. Matsuda, and M. Nagai. 1997. Anti-tumor promoting activities of isoflavonoids from Wistaria brachybotrys. Biol. Pharm. Bull. 20 865-868. 

Soyasapogenol B, soyasaponins I and II and wistariasaponins from Wistaria brachybotrys (wistariasaponin C corresponds to astragaloside VIII) decreased (20-30%) the Epstein-Barr Virus (EBV) activation induced by the tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate) in Raji cells at a concentration of lxlO2 mol ratio [151]. Soyasaponin I from the same plant exhibited remarkable inhibitory effects on mouse skin tumor promotion on the basis of the two-stage DMBA-TPA carcinogenesis test in vivo. Soyasaponin I reduced the number of papillomas per mouse at about 40% even at 20 weeks [152]. 

Furthermore, twelve isoflavonoids (21 -32) were isolated from the knots of Wistaria brachybotrys, which have been used as a folk medicine in Japan for the treatment of gastric cancer, and their inhibitory effects on EBV-EA activation were also examined [16, 31]. Of these compoimds, an isoflavanquinone, pendulone (25) and an isoflavan, isomucronulatol (26) exhibited the most potent inhibitory activity (more than 85% inhibition... 

Triterpenoids from Gleditsia japonica, Gymnocladus chinensis and Wistaria brachybotrys... 

Furthermore, from the knots of Wistaria brachybotrys, several kinds of oleanane type saponins (101 - 108) were isolated together with isoflavonoids. Of these saponins, wistariasaponins A, Bl, B2, C, D and G were found to be novel saponins, and their structures of sapogenols were elucidated by the long-range COSY spectra and difference NOE... 

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