Effect on central nervous system

Lotti M, Becker CE. 1982. Treatment of acute organophosphate poisoning Evidence of a direct effect on central nervous system by 2-PAM (pyridine-2-aldoxime methyl chloride). J Toxicol Clin Toxicol 19 121-127. 

Panax quinquefolium L. XiYang Seng (American ginseng) (root) Ginsenosides, phytosterols.26 Stimulating effect on central nervous system, antifatigue. 

Laganiere, S. Corey, J. Tang, X. C. Wulfert, E. Hanin, I. Acute and chronic studies with the anticholinesterase huperzine A effect on central nervous system cholinergic parameters. Neuropharmacology, 1991, 30 763-768. 

Dubinsky, B., Sierchio, J.N., Temple, D.E. (1984). Flunarizine and verapamil effects on central nervous system and peripheral consequences of cytotoxic hypoxia in rats. Life Sci. 34 1299-1306. 

Clinically, the main benefit of oximes is to reverse cholinergic effects at peripheral nicotinic sites so that, for example, muscle strength may improve. Oximes are much less effective than atropine at peripheral muscarinic sites and their effects on central nervous system-mediated symptoms and signs may not be clinically significant. 

ACUTE HEALTH RISKS irritation of eyes, skin and respiratory tract cough shortness of breath dizziness headache weakness confusion nausea vomiting pulmonary irritation muscle weakness malaise (vague feeling of discomfort) effects on central nervous system lowering of consciousness effects on the thyroid. 

HEALTH SYMPTOMS inhalation (dizziness, drowsiness, headache, nausea, lung edema, effects on central nervous system, blood effects, lowering of consciousness) skin contact (dry skin, redness, dermatitis) eye contact (redness) ingestion (effects on the liver and kidney). 

CHRONIC HEALTH RISKS headaches numbness weakness dizziness tremors loss of appetite effects on central nervous system deafness loss of muscle coordination loss of visual acuity respiratory effects cardiovascular effects cretinism enlarged thyroid gland congenital hypothyroidism in newborns malformation in fetus low fetal body weights in animals. 

CHRONIC HEALTH RISKS may have effects on central nervous system may also have effects on the liver possible carcinogenic to humans possible toxic effects upon human reproduction based on animal tests. 

ACUTE HEALTH RISKS drowsiness loss of consciousness due to asphyxia may cause effects on central nervous system cardiac arrhythmia cardiac arrest liquid may cause frostbite. 

ACUTE HEALTH RISKS corrosive to skin, eyes and upper respiratory tract destructive to tissues of mucous membranes may cause lung edema blue lips or fingernails blue skin cough dizziness headache labored breathing burning sensation nausea vomiting diarrhea abdominal cramps weakness ataxia tremors anoxia convulsions edema of the larynx and bronchi chemical pneumonitis may cause effects on central nervous system, liver and blood exposure at high concentrations may result in death. 

ACUTE HEALTH RISKS irritation of skin, eyes, and respiratory system cough headache sore throat shortness of breath cyanosis narcosis nausea pulmonary edema pulmonary irritation effects on central nervous system respiratory failure rapid evaporation of the liquid may cause frostbite death in high concentrations. 

CHRONIC HEALTH RISKS prolonged contact may cause dermatitis may cause skin sensitization may have effects on central nervous system, kidneys and liver. 

CHRONIC HEALTH RISKS effects on central nervous system weakness fatigue depression headache possible liver damage reproductive effects peripheral neuropathy effects on blood minor effects on kidney enzyme functions increased risk of leukemia increased risk of lymphoma EPA Group C possible human carcinogen. 

ACUTE HEALTH RISKS convulsions dizziness headache nausea abdominal pain diarrhea burning sensation hallucinations dullness insomnia bad dreams anxiety restlessness poor appetite delirium violent behavior hypotension unconsciousness may cause effects on central nervous system, resulting in encephalopathy may result in death. 

ACUTE HEALTH RISKS headache, dizziness nausea vomiting convulsions unconsciousness effects on central nervous system gastrointestinal effects coma death at high concentrations. 

---