Appetite, effect

Animal studies support the reputation of cannabis for stimulating appetite, although this effect has not been universally reported (Graceffo and Robinson 1998). Sated rats showed substantial hyperphagia when administered THC at doses of 0.5, 1.0, and 2.0 mg/kg (Williams et al. 1998). This appetitive effect of THC was found in other species, such as dogs, whereas LSD, by contrast, produces anorexia (Vaupel and Morton 1982). 

CHRONIC HEALTH RISKS headaches numbness weakness dizziness tremors loss of appetite effects on central nervous system deafness loss of muscle coordination loss of visual acuity respiratory effects cardiovascular effects cretinism enlarged thyroid gland congenital hypothyroidism in newborns malformation in fetus low fetal body weights in animals. 

Normally, dietary tyramine is broken down in the gastrointestinal tract by MAO and is not absorbed. In the presence of MAOI, however, all of its potent sympathomimetic actions are seen. Other side effects of MAOI include excessive CNS stimulation, orthostatic hypotension, weight gain, and in rare cases hepatotoxicity. Because the monoamine oxidase inhibitors exhibit greater toxicity, yet no greater therapeutic response than other, newer agents, clinical use has been markedly curtailed. The primary use for MAOIs is in the treatment of atypical depressions, eg, those associated with increased appetite, phobic anxiety, hypersomnolence, and fatigues, but not melancholia (2). 

Appetite suppressants have been widely used as an adjunct to dietary restriction and sympathomimetic amines have traditionally been used for this purpose. These agents have not proven particularly useful and frequentiy cause unacceptable side effects, hence their popularity has been waning for several years. The most promising newer dmgs work through a serotoninergic mechanism and hold considerable promise at least for certain obese patients. 

Since about 85% of the administered dose is passed unchanged in the feces of the patient, selective toxicity of the dmg can be attributed primarily to poor absorption. Side effects include abdominal pain, nausea, vomiting, diarrhea, loss of appetite, headaches, and vertigo or drowsiness. Skin rashes can also develop. Pyrantel pamoate is produced by Pfi2er, Inc., New York, New York. 

Appetite-suppressing. Neuropqrtide modulators and gut hormones with anorexigenic effects are a-melanocortin-stimulating hormone (a-MSH), cocaine- and amphetamine-regulated transcript (CART), glucagon-like peptide-1 (GLP-1), leptin, insulin, oxyntomodulin, pancreatic peptide PP, peptide YY and PYY3 36, and others. 

Effect Reduced fat absorption Appetite suppression Appetite suppression, peripheral actions... 

The appetite-suppressing effect of (3-phenylethylamine drugs is either related to their sympathomimetic effect (metamphetamine, phentermine, diethylpropion), to... 

Drags with Appetite-Stim nlating Effects Psychotropic Drugs... 

Stimulation of appetite and weight gain has frequently been observed as a side effect of long-term therapy with various psychoactive drugs. Prominent examples not... 

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