Easy ambient sonic-spray ionization mass spectrometry

Hu, J.-B., Chen, T.-R., Chang, C.-H., Cheng, J.-Y., Chen, Y.-C., Urban, P.L. (2015) A Compact 3D-Printed Interface for Coupling Open Digital Microchips with Venturi Easy Ambient Sonic-Spray Ionization Mass Spectrometry. Analyst 140 1495-1501. 

In 2008, easy ambient sonic-spray ionization mass spectrometry (EASI-MS), originally named desorption sonic spray ionization (DeSSI), was coupled with TLC [69], later with HPTLC [70]. An acidic mixture of methanol and water was sprayed at a maximum flow rate of 15 pL/min coaxial with the supersonic nebulizing gas set at 30 bar. The spray beam of the homemade easy ambient sonic-spray ionization (EASI) source was mounted on the supplied nano-electrospray ionization (nano-ESI) source and directed in a 30-degree angle onto the plate. Without any voltage or heating, just the impact of a high velocity spray served to extract and desorb analytes from the TLC surface and softly ionize them. 

Haddad, R., Milagre, H.M.S., Catharine, R.R., Eberlin, M.N. (2008) Easy ambient sonic-spray ionization mass spectrometry combined with thin-layer chromatography. Analytical Chemistry, 80,2744-2750. 

Eberlin, L.S., Abdelnur, P.V., Passero, A., de Sa, G.F., Daroda, R.J., de Souza, V, Eberlin, M.N. (2009) Analysis of biodiesel and biodiesel-petrodiesel blends by high performance thin layer chromatography combined with easy ambient sonic-spray ionization mass spectrometry. Analyst, 134,1652-1657. 

Sabino, B.D., Sodre, M.L., Alves, E.A., Rozembaum, H.F., Alonso, F.O.M, Correa, D.N., Eberlin, M.N., and Romao, W. 2010. Analysis of street Ecstasy tablets by thin layer chromatography coupled to easy ambient sonic-spray ionization mass spectrometry, Braz. J. Anal. Chem., 1 6-11. 

Romao, W., Sabino, B.D., Bueno, M.I.M.S., Vaz, B.G., Junior, A.C., Maldaner, A.O., Castro, E.V.R. et al. 2012. LSD and 9,10-dihydro-LSD Analyses in street drug blotter samples via easy ambient sonic-spray ionization mass spectrometry (EASI-MS), J. 

Easy ambient sonic-spray ionization mass spectrometry (EASI-MS) for crude oil analysis... 

Haddad, R. Catharine, R.R. Marques, L.A. Eberlin, M.N. Perfume Fingerprinting by Easy Ambient Sonic-Spray Ionization Mass Spectrometry Nearly Instantaneous Typification and Counterfeit Detection. Rapid Commun. Mass Spectrom. 2008,22, 3662-3666. 

Chapter 6, titled Selection of Ionization Methods of Analytes in the TLC-MS Techniques provides an overview of mass spectrometric techniques that can be coupled with TLC and act as specific detectors in this hyphenated approach. The mass spectrometric techniques discussed in this chapter are secondary mass spectrometry (SIMS), liquid secondary ion mass spectrometry (LSIMS), fast atom bombardment (FAB), matrix-assisted laser desorption/ionization (MALDI), atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI), electrospray ionization (ESI), desorption electrospray ionization (DESI), electrospry-assisted laser desorption/ionization (ELDI), easy ambient sonic spray ionization (EASI), direct analysis in real time (DART), laser-induced acoustic desorption/electrospray ionization (LIAD/ESI), plasma-assisted multiwavelength laser desorption/ionization (PAMLDI), atmospheric-pressure chemical ionization (APCI), and dielectric barrier discharge ionization (DBDI). For the sake of illustration, the authors introduce practical examples of implementing TLC separations with detection carried out by means of individual mass spectrometric techniques for the systematically arranged compounds belonging to different chemical classes. 

Romao, W., Lalli, P.M., Franco, M.F., Sanvido, G., Schwab, N.V., Lanaro, R., Costa, J.L. et al. 2011. Chemical profile of meta-chlorophenylpiperazine (m-CPP) in ecstasy tablets by easy ambient sonic-spray ionization. X-ray fluorescence, ion mobility mass spectrometry and NMR, Anal. Bioarud. Chem., 400 3053-3064. 

Haddad, R. Sparrapan, R Kotiaho, T. Eberlin, MN. (2008). Easy ambient sonic-spray ionization-membrane interface mass spectrometry for direct analysis of solution constituents. Analytical Chemistry, Vol.80, No.3, pp. 898-903, ISSN 1520-6882. 

---