Interfaces mass spectrometry

M. Car eri, A. Mangia and M. Musci, Overview of the applications of liquid cliromatog-raphy-mass spectrometry interfacing systems in food analysis naturally occurring substances in food , 7. Chromatogr. 794 263-297 (1998). 

The characteristics of an ideal liquid chromatography-mass spectrometry interface have been discussed, with emphasis having been placed upon the major incompatibilities of the two component techniques that need to be overcome to allow the combination to function effectively. 

Simpson, R. C. Fenselau, C. Hardy, M. R. Townsend, R. R. Lee, Y. C. Cotter, R. J. Adaptation of a thermospray liquid chromatography/mass spectrometry interface for use with alkaline exchange liquid chromatography of carbohydrates. Anal. Chem. 1990, 62, 248-252. 

McLoughlin, D.A., Olah, T.V., and Gilbert, J.D. 1997. A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system. J. Pharm. Biomed. Anal. 15 1893. 

M.A. Baldwin and F.W. McLafferty, Liquid chromatography-mass spectrometry interface. I The direct introduction of liquid solutions into a chemical ionization mass spectrometer, Org. Mass Spectrom., 7 (1973) 1111-1112. 

Wang C., Oleschuk R., Ouchen F., Li J., Thibault R, and Harrison D.J. (2000), Integration of immobilized trypsin bead beds for protein digestion within a micro-fluidic chip incorporating capillary electrophoresis separations and an electrospray mass spectrometry interface, Rapid Commun. Mass Spectrom. 14(15), 1377-1383. 

Millington, D.S. Yorke, D.A. Bums, P. A New Liquid Chromatography-Mass Spectrometry Interface. Adv. Mass Spectrom. 1980, SB, 1819-1825. 

Liu, C. C., Jong, R., and Covey, T. (2003). Coupling of a large-size capillary column with an electrospray mass spectrometer. A reliable and sensitive sheath flow capillary electrophoresis-mass spectrometry interface.. Chromatogr. A 1013, 9-18. 

Chen, Y. R., Tseng, M. C., and Her, G. R. (2005). Design and performance of a low-flow capillary electrophoresls-electrospray-mass spectrometry interface using an emitter with dual beveled edge. Electrophoresis 26, 1376—1382. 

Kele, Z., Eerenc, G., Klement, E., Toth, G. K., and Janaky, T. (2005). Design and performance of a sheathless capillary electrophoresis/mass spectrometry Interface by combining fused-slllca capillaries with gold-coated nanoelectrospray tips. Rapid Commun. Mass Spectrom. 19, 881 — 885. 

Waterval, J. C. M., Bestebreurtje, P., Lingeman, H., Versluis, C., Heck, A. J. R., Bult, A., and Underberg, W. J. M. (2001). Robust and cost-effective capillary electrophoresis-mass spectrometry interfaces suitable for combination with on-line analyte preconcentration. Electrophoresis 22, 2701-2708. 

Whitt, J. T, and Moini, M. (2003). Capillary electrophoresis to mass spectrometry interface using a porous junction. Anal. Chem. 75, 2188—2191. 

LW Tetler, PA Cooper, B Powell. Influence of capillary dimensions on the performance of a coaxial capillary electrophoresis-electrospray mass spectrometry interface. J Chromatogr A 700 21-26, 1995. 

C Siethoff, W Nigge, M Linscheid. Characterization of a capillary zone elec-trophoresis/electrospray-mass spectrometry interface. Anal Chem 70 1357-1361, 1998. 

Which liquid chromatography-mass spectrometry interface, atmospheric pressure chemical ionization or electrospray, requires analyte ions to be in solution prior to the interface How does the other interface create gaseous ions from neutral species in solution ... 

Mass Spectrometry Interface with Gas Chromatography (GCjMS)... 

Thompson, A.J., A.S. Creba, R.M. Ferguson, E.T. Krogh, and C.G. Gill. 2006. A coaxially heated membrane introduction mass spectrometry interface for the rapid and sensitive on-line measurement of volatile and semi-volatile organic contaminants in air and water at parts-per-trillion levels. Rapid Commun. Mass Spectrom. 20 2000-2008. 

Capillary Electrophoresis Inductively Coupled Plasma Mass Spectrometry-Interfaces and Applications... 

Frequently industrial hygiene analyses require the identification of unknown sample components. One of the most widely employed methods for this purpose is coupled gas chromatography/ mass spectrometry (GC/MS). With respect to interface with mass spectrometry, HPLC presently suffers a disadvantage in comparison to GC because instrumentation for routine application of HPLC/MS techniques is not available in many analytical chemistry laboratories (3). It is, however, anticipated that HPLC/MS systems will be more readily available in the future ( 5, 6, 1, 8). HPLC will then become an even more powerful analytical tool for use in occupational health chemistry. It is also important to note that conventional HPLC is presently adaptable to effective compound identification procedures other than direct mass spectrometry interface. These include relatively simple procedures for the recovery of sample components from column eluate as well as stop-flow techniques. Following recovery, a separated sample component may be subjected to, for example, direct probe mass spectrometry infra-red (IR), ultraviolet (UV), and visible spectrophotometry and fluorescence spectroscopy. The stopped flow technique may be used to obtain a fluorescence or a UV absorbance spectrum of a particular component as it elutes from the column. Such spectra can frequently be used to determine specific properties of the component for assistance in compound identification (9). 

W. G. Pretorius, L. Ehdon, S. J. Rowland, Development of a high-temperature gas chromatography - inductively coupled plasma mass spectrometry interface for the determination of metalloporphyrins, J. Chromatog., 646 (1993), 369-375. 

Tumor markers are measured by a variety of analytical techniques including enzyme assay (Chapters 8 and 21) immunoassay (Chapter 9) receptor assay and instrumental techniques such as chromatography (Chapter 6) electrophoresis (Chapter 5) mass spectrometry interfaced with either liquid or gas chromatographs (Chapter 7) and microarrays. Details of these techniques are found in the indicated chapters. Here we expand on the use of mass spectrometry and microarrays for the assay of protein and genetic tumor markers. 

Sjoberg, J.R. Markides, K.E. Capillary Column Supercritical Fluid Chromatography-Atmospheric Pressure Ionisation Mass Spectrometry Interface Performance of Atmospheric Pressure Chemical Ionisation and Electrospray Ionisation,", 7. Chromatogr. A 855, 317-327 (1999). 

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