Drugs cisplatin

Modes of Action of Anti-tumor Drug Cisplatin... 

Hilder TA, Hill JM (2007) Modelling the encapsulation of the anticancer drug cisplatin into carbon nanotubes. Nanotechnology 18 Art. No. 275704. 

Pil, P.M. and Lippard, S.J. (1992) Specific binding of chromosomal protein HMGl to DNA damaged by the anticancer drug cisplatin. Science 256, 234-237. 

Huang JC, Zamble DB, Reardon JT, Lippard SJ, Sancar A (1994) HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer-drug cisplatin by human excision nuclease. Froc Natl Acad Sd USA 91 10394-10398... 

Antitumor drugs cisplatin as, history, 37 175-179 platinum compounds future studies, 37 206-208 resistance to, 37 192-193 second-generation, 37 178 Antiviral agents, 36 37-38 AOR, see Aldehyde oxidoreductase Aphanothece sacrum, ferredoxins, amino acid sequence, 38 225-227 Apo-calcylin, 46 455 Apo-caldodulin, 46 449-450 Apoenzyme, 22 424 Apoferritin biosynthesis, 36 457 cystalline iron core, 36 423 Fe(III)distribution, 36 458-459 Fe(II) sequestration, 36 463-464 ferroxidase centers, 36 457-458 iron core reconstruction in shell, 36 457 mineralization, 36 25 Mdssbauer spectra, 36 459-460 optical absorbance spectra, 36 418-419 subunit conformation and quaternary structure, 36 470-471... 

A study has been made of the DNA secondary structure induced by the various nucleohistone complexes 342). The interaction of calf thymus DNA with the anticancer drug Cisplatin in water and heavy water has been studied. The carbonyl bands at 1710 and 1686 cm-1 of the control DNA disappear and shift to lower frequencies in the spectra of the products of the reaction. The drug induces a reorganization of the water molecules and the DNA structure is modified 340). 

Reaction of the anti-cancer drug cisplatin, Pt(NH3)2Cl2, with water is described by the equation... 

There have been numerous studies of the interaction of the highly effective anticancer drug cisplatin, c/5-[Pt(NH3)2Cl2], with DNA. The majority of these studies have concentrated on the adduct formed between the platinum(II) ion and two adjacent guanine bases (G) on one strand of DNA this is the adduct most frequently... 

Takahara, P. M.. Rosenzweig, A. C., Frederick, C. A., Lippard, S. J., Crystal-structure of double-stranded DNA containing the major adduct of the anticancer drug Cisplatin. Nature 1995, 377, 649-652. 

Investigations of small molecules of biological interest by EXAFS include identification as to whether or not dimeric products of the anticancer drug cisplatin are formed before its interaction with DNA (Teo et al., 1978 Hitchcock et al., 1982) and determination of the fate of gold-based antiarthritic drugs which have been shown to be polymeric when absorbed into cells (Mazid et al., 1980). 

Of the platinum-based drugs, cisplatin or cf -diarnmincdichloroplatinum (II) has been the most studied in treatments of cancerous tumours. Quantities of the drug administered in treatments must be carefully controlled because of appearances of side effects, primarily nephrotoxicity and nausea in patients. In some studies, ultrafilterable cisplatin, or free platinum in blood serum or plasma has been differentiated from platinum bound to proteins (Goel et al., 1990). HPLC has been used extensively in separations of intact cisplatin from other species. An anion-exchange column was connected to a post-column reactor and a UV-spectrophotometer for measurements of cisplatin concentrations in plasma and urine (Kizu et al., 1995). The detection limit was 20 nmol dm-3. Modes of action... 

Direct reactions with DNA serve as the molecular basis for the action of several anti-tumor drugs. Cancer is primarily a disease of uncontrolled cell growth, and cell growth depends on DNA synthesis. Cancer cells are often more sensitive than normal cells to compounds that damage DNA. For example, the anti-tumor drug cisplatin reacts with guanine bases in DNA and the daunomycin antibiotics act by inserting into the DNA chain between base pairs. In either case, these biochemical events can lead to the death of a tumor cell. 

The level of pentosidine of nondiabetic pulmonary cancer patients in treatment with the antineoplastic drug, cisplatin, has been found to be higher than in healthy subjects,443 when the protein from urine, plasma, and erythrocyte membranes was examined by HPLC. Urine pyrraline was unaffected. This work implies a whole field of study of the interactions of medication with the Maillard reaction. 

T) Do direct chemical interactions occur between rescue agents and platinum compounds (such as the drugs cisplatin and carboplatin transpla-tin), and between the relevant model compounds (such as Ptn(dien), or perhaps the kinetically faster reacting Pd11 compounds) Which interaction products are formed in vivo (structure, kinetics) This topic has been largely neglected in the literature. 

The parent drug, cisplatin, has proved to be one of the most successful anticancer drugs yet developed and, in particular, has made a significant... 

The preferential binding of the antitumour drug cisplatin (ds-diamminechloroplatinum-II) to GpG and ApG sequences in DNA has prompted the use of ab initio calculations with relativistic pseudopotentials to evaluate three important parameters for the Pt-adenine model complex [Pt(NH3)3 adenine]. These are the force constant for the Pt—N-7 bond bending out of the adenine... 

Thioethers form stable complexes, particularly if they are polydentate. Whereas only two sulfur atoms are coordinated in Ph2Pt(9S3),26 larger macrocycles, as in [Pt(12S4)]2+, can encapsulate the metal atom.27 The L-methionine complex (18-H-XII) is a metabolite of the anti-cancer drug cisplatin (see below).28... 

BLEOMYCIN ANTICANCER AND IMMUNOMODULATING DRUGS-CISPLATIN t bleomycin levels, with risk of pulmonary toxicity Elimination of bleomycin is delayed by cisplatin due to 1 glomerular filtration. This is most likely with accumulated doses of cisplatin in excess of 300 mg/m2 Monitor renal function and adjust dose of bleomycin as per creatinine clearance. Monitor clinically, radiologically and with lung function tests for pulmonaiy toxicity... 

Ishida S, Lee J, Thiele DJ, Herskowitz I. Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctrl in yeast and mammals. Proc Natl Acad Sci USA 2002 99 14298-302. 

Clinically important, potentially hazardous interactions with cholesterol-lowering drugs, cisplatin, clozapine, dimercaprol, niacin, oral corticosteroids, simvastatin... 

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