Anticancer drugs cisplatin

Hilder TA, Hill JM (2007) Modelling the encapsulation of the anticancer drug cisplatin into carbon nanotubes. Nanotechnology 18 Art. No. 275704. 

Pil, P.M. and Lippard, S.J. (1992) Specific binding of chromosomal protein HMGl to DNA damaged by the anticancer drug cisplatin. Science 256, 234-237. 

Huang JC, Zamble DB, Reardon JT, Lippard SJ, Sancar A (1994) HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer-drug cisplatin by human excision nuclease. Froc Natl Acad Sd USA 91 10394-10398... 

A study has been made of the DNA secondary structure induced by the various nucleohistone complexes 342). The interaction of calf thymus DNA with the anticancer drug Cisplatin in water and heavy water has been studied. The carbonyl bands at 1710 and 1686 cm-1 of the control DNA disappear and shift to lower frequencies in the spectra of the products of the reaction. The drug induces a reorganization of the water molecules and the DNA structure is modified 340). 

There have been numerous studies of the interaction of the highly effective anticancer drug cisplatin, c/5-[Pt(NH3)2Cl2], with DNA. The majority of these studies have concentrated on the adduct formed between the platinum(II) ion and two adjacent guanine bases (G) on one strand of DNA this is the adduct most frequently... 

Takahara, P. M.. Rosenzweig, A. C., Frederick, C. A., Lippard, S. J., Crystal-structure of double-stranded DNA containing the major adduct of the anticancer drug Cisplatin. Nature 1995, 377, 649-652. 

Investigations of small molecules of biological interest by EXAFS include identification as to whether or not dimeric products of the anticancer drug cisplatin are formed before its interaction with DNA (Teo et al., 1978 Hitchcock et al., 1982) and determination of the fate of gold-based antiarthritic drugs which have been shown to be polymeric when absorbed into cells (Mazid et al., 1980). 

Ishida S, Lee J, Thiele DJ, Herskowitz I. Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctrl in yeast and mammals. Proc Natl Acad Sci USA 2002 99 14298-302. 

Cisplatin complexes with ATP. In a continuation of previous studies, Jiang and Mao reported the results of a study of the complexation of the anticancer drug cisplatin with ATP. The authors made use of long-range HMBC data in the study, and although... 

The anticancer drugs cisplatin cyclophosphamide - and ifosfamide alter the profile of P450 enzyme expression in liver and perhaps other tissues, at least in part due to the hormonal perturbations that these cytotoxic agents induce. Treatment of adult male rats with a single dose of cisplatin depletes serum androgen, and this effect persists for up to 28 days after drug administration . Serum androgen depletion by cisplatin is associated with a feminization of hepatic liver enzyme expression. Thus, cisplatin-treated male rats have elevated levels of the female-predominant... 

Figure 4 Interaction between metal-complex anticancer drugs, cisplatin (CDDP), and the core-forming segments of the block copolymers PEG-P(Asp) and PEG-P(Glu). The methane group in the side chain of PEG-P(Glu) was reported to play an important role in significantly increasing the stabihty of the micelles compared to PEG-P(Asp).

A few synthetic approaches were reported to obtain sets of new 1,2,4-triazine derivatives. A well-known synthetic protocol was used to prepare a series of the 1,2,4-triazine derivatives 14 bearing a piperazine amide moiety. The synthetic route included the condensation of S-methyl thiosemicarba-zide 15 and benzil derivatives 16 followed by nucleophilic substitution of the methylthio group with piperazine resulting in 1,2,4-triazines 17 and further functionalization of the piperazine moiety. In vitro antitumor activity against breast cancer cells of the 1,2,4-triazines 14 was evaluated using the XTT method, BrdU method, and flow cytometric analysis. A few of the compounds demonstrated antiproliferative effect comparable with an effective anticancer drug, cisplatin (14BMC6313). 

The compound [Pt(NH3)2Cl2] was first prepared In 1845 by two different synthetic routes. The a form of the compound (known as Peyrone s salt) was made by the reaction of [PtC ] " with NH3, while the / form (also called Resiet s second chloride) resulted when [Pt(NH3)4]Cl2 was heated to 250 °C. Many years later, Alfred Werner showed that the two compounds were isomers of each other and suggested that they had square planar molecular geometries. Currently, we know the a form as the anticancer drug cisplatin, c/s-[Pt(NH3)2Cl2], and the form as its geometrical isomer trans-[Pt(NH3)2Cl2]. 

Since the great success of the inorganic anticancer drug cisplatin, metal-based drug candidates are suspected to interfere with DNA, for example, by direct coordination. Incubation of salmon testes DNA with 31-36 showed efficient DNA association for all compoimds [109]. Indeed, the attachment was more efficient than for cisplatin. Even more effective was the precursor Co2(CO)s. This suggests that the interaction with DNA results from the cobalt-alkyne moiety. However, a correlation between the efficiency of DNA association and cytotoxicity could not be found. Moreover, after incubation with cobalt salicylates, the nuclei of both MCF-7 and MDA-MB 231 cells did not contain significant amounts of cobalt, as determined by atomic absorption spectroscopy [109]. Cell... 

Hilder TA, HiU JM. Encapsulation of the anticancer drug cisplatin into nanotubes. In International conference on nanoscience and nanotechnology (ICONN 08) Febmary 2008. p. 109-12. 

Pil PM, Lippard SJ (1992) Specific binding of chromosomal protein HMGl to DNA damaged by the anticancer drug cisplatin. Science 256 234-237 Prigent P, Saoudi A, Druet P, Hirsch F (1993) In vitro effects of mercuric chloride on splenocytes from susceptible Brown-Norway rats and non-susceptible Lewis rats cytokine involvement. JASN 4 628 (abstract)... 

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