Cisplatin drug interactions

The possible impact of co-administered chemotherapies and radiation therapy on the PK of cetuximab was furthermore assessed using the population PK approach, as described in Section 14.6. The co-administered chemotherapies included cisplatin, carboplatin, paclitaxel, doxorubicin, irinotecan, and gemcitabine. The results of the analysis indicate that neither the co-administered chemotherapies nor radiation therapy had a significant impact on the PK of cetuximab. This finding suggests that the potential for PK-based drug-drug interactions with cetuximab is low. 

Neault JF, Benkirane A, Malonga H, et al. Interaction of cisplatin drug with Na,K-ATPase drag binding mode and protein secondary structure. J Inorg Biochem 2001 86(2-3) 603-609. 

Schedules for optimal use alone or in combination with other drugs, including doxorubicin and cisplatin, still are evolving. Drug interactions have been noted the sequence of cisplatin preceding paclitaxel decreases paclitaxel clearance and produces greater toxicity than the opposite schedule. Paclitaxel decreases doxorubicin clearance and enhances cardiotoxicity, whereas docetaxel has no apparent effect on anthracycline pharmacokinetics. 

Ceul M, van Waardenburg RC, Beijnen JH and ScHELLENS JHM (2002) DNA-based drug interactions of cisplatin. Cancer Treat Rev 28(6) 291-303. 

Pietruszka LJ, Biermann WA, Vlasses PH. Evaluation of cisplatin-lithium interaction. Drug IntellClinPharm( 9S5) 19,31-2. 

Schilder RJ, Hall L, Monks A, Handel LM, Fornace AJ Jr, Ozols RF, Fojo AT, Hamilton TC (1990) Metallothionein gene expression and resistance to cisplatin in human ovarian cancer. Int J Cancer 45 416-422 Sharma RP, Edwards IR (1983) Cisplatinum subcellular distribution and binding to cytosolic ligands. Biochem Pharmacol 32 2665-2669 Sherman SE, Lippard SJ (1987) Structural aspects of platinum anticancer drug interactions with DNA. Chem Rev 87 1153-1181 Shimizu T, Kubota M, Tanizawa A, Sano H, Kasai Y, Hashimoto H, Akiyama Y, Mikawa H (1990) Inhibition of both etoposide-induced DNA fragmentation and activation of poly (ADP-ribose) synthesis by zinc ion. Biochem Biophys Res Commun 169 1172-1177... 

The cis isomer ( cisplatin ) is an effective anticancer drug. This reflects the ability of the two Cl atoms to interact with the nitrogen atoms of DNA, a molecule responsible for cell reproduction. The trans isomer is ineffective in chemotherapy, presumably because the Q atoms are too far apart to react with a DNA molecule. 

Recent reviews in the field of platinum anticancer drugs focus on platinum-nucleobase chemistry [7], biological processing of platinum-modified DNA [8], trans-platinum anticancer drugs [5], cisplatin and derived anticancer drugs [4,9], proteins and cisplatin [10], trans-diam-mineplatinum(II) and nucleic acids [11], and catalytic activity and DNA [12], just to mention a few. The aim of this review is to explore the chemistry in the interaction of various platinum compounds with nucleic... 

The conversion of the monofunctional adducts into bifunctional lesions depends drastically on the structure of the Pt drug. Obviously, Pt compounds exhibiting trans geometry form different bisadducts than cisplatin and hence, a different spectrum of antitumor activity is expected. Mechanistically, the formation and possible isomerization of bisadducts are not well understood. The assumption that hydrolysis of the second leaving group controls the formation of bisadduct may be an oversimplification. Studies with model compounds as well as with oligonucleotides have indicated that a certain nucleobase may be a powerful nucleophile toward Pt(II) if spatially in a correct position. Unfortunately, our knowledge on these interactions is at present very limited. 

Lee YJ, Park SJ, Ciccone SL, Kim CR, Lee SH (2006) An in vivo analysis of MMC-induced DNA damage and its repair. Carcinogenesis 27(3) 446-453 Loehrer PJ, Einhom LH (1984) Drugs five years later. Cisplatin. Ann Intern Med 100(5) 704-713 Li G, Widom J (2004) Nucleosomes facilitate their own invasion. Nat Struct Mol Biol 11 763-769 Liu W, Sun D, Hurley LH (2005) Binding of G-quadruplex interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaca cells. Nucleosides Nucleotides Nucleic Acids 24(10-12) 1801-1815... 

Drugs that may interact with zalcitabine include antacids, chloramphenicol, cisplatin, dapsone, didanosine, disulfiram, ethionamide, glutethimide, gold, hydralazine, iodoquinol, isoniazid, metronidazole, nitrofurantoin, phenytoin, ribavirin, vincristine, cimetidine, metoclopramide, amphotericin, aminoglycosides, foscarnet, antiretroviral nucleoside analogs, pentamidine, and probenecid. 

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