Drosophila zeste

Drosophila zeste somatic eye mutation test. Mutat. Res. 1984,138,169-173. 

Xamena N, Velazquez A, Batiste-Alentom M, et al. 1988. Genotoxicity studies with four organophosphorus insecticides using the unstable white-zeste system of drosophila melanogaster. Mutat Res 204 251-256. 

Fujikawa K, Ryo H, Kondo S. 1985. The Drosophila reversion assay using the unstable zeste-white somatic eye color system. In Ashby J, de Serres FJ, et al., eds. Progress in mutation research. Vol. 5. Evaluation of short-term tests for carcinogens. Amsterdam, The Netherlands Elsevier Science Publishers, 319-324. 

Czermin, B., Melfi, R., McCabe, D., Seitz, V., Imhof, A., and Pirrotta, V. (2002) Drosophila Enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111, 185-196. 

DMM. Drosophila melanogaster, somatic mutation (zeste-white locus) (+) 590 feed Batiste-Alentom et al. 

Batiste-Alentom, M., Xamena, N., Creus, A. Marcos, R. (1991) Genotoxicity studies with the unstable zeste-white (UZ) system of Drosophila melanogaster. results with ten carcinogenic compounds. Environ, mol. Mutag., 18, 120-125... 

Park, M., Venkatesh, T.V., and Bodmer, R. (1998b). Dual role for the zeste-white3/shaggy-encodes kinase in mesoderm and heart development of Drosophila. Dev. Genet. 22 201-211. 

Jones, R. S., and Gelbart, W. M. (1993). The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol. 13(10), 6357-6366. 

SET2 histone lysine methyltransferase encoded from short arm chromosome 3 specific for lysine-36 of histone H3 orthologous to S. cerevisiae interacts with p53 involved in mismatch repair acts as mmor suppressor (kidney carcinoma). Suppressor of variegation Enhancer of zeste Trithorax (drosophila) Dalgliesh GL et al Nature 2010 463 360-363. Li M et al Proc Nad Acad Sci USA 2006 102 17836-17841. 

Demethylase gene PRDMl encodes B lymphocyte-induced maturation protein BLIMP 1 descendant of krox gene of sea urchin S. purpuratus originator of the SET domain Su(var) Enhancer of zeste trithorax (discovered in drosophila). KDM = lysine demethylase (Hemming S et al Stem Cells 2014 32 802-815). 

Zeste-tko region in natural populations of Drosophila melanogaster. Mol. Biol Evol 6 123-130. 

In the Drosophila embryo, zug is required for formation of parasegment boundaries and for maintenance of engrailed (en) expression in adjacent cells (Wodarz Nusse, 1998). Embryos with mutations in genes porcupine (pore), dsh, armadillo (arm) and pangolin (pan), exhibit a very similar phenotyp>e. By contrast, mutations in zeste-white 3 (zw3) demonstrate an opposite phenotype, a naked cuticle. 

Methylation of histone lysine residues is catalysed by site- and methylation-state specific i.e. tri-/di-/monomethylation states) histone methyltransferases (EC number 2.1.1.43, Table 5.4). With the exception of DOTIL, which methylates H3K79, all identified KMTs catalyse methylation using a SET domain (SET is an abbreviation for Su(var)3-9, Enhancer of zeste and Trithorax and refers to the Drosophila protein suppressor of variegation where this domain was first identified). ... 

Platero J.S., Csink A.K., QuintanUla A., and Henikofif S. 1998. Changes in chromosomal localization of heterochromatin-binding proteins during the ceU cycle in Drosophila. J. Cell Biol. 140 1297—1306. Rastelli L., Chan C.S., and Pirrotta V. 1993. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer cf zeste function. EMBO J. 12 1513-1522. 

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