Proteins polycomb group

Klymenko T, Papp B, Fischle W, Kocher T, Schelder M, Fritsch C, Wild B, Wilm M, Muller J (2006) A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysinebinding activities. Genes Dev 20 1110-1122... 

Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM (2002) The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419 624-629 Wade PA, Pruss D, Wolffe AP (1997) Trends Biochem Sci 22 128-132... 

Vire, E. et al. (2006) The Polycomb group protein EZH2 directly controls DNA methylation. Nature, 439, 871-874. 

Kohler, C. c Grossniklaus, U. (2002). Epagenetic inheritance of expression states in plant development the role of Polycomb group proteins. Current Opinion in Cell Biology, Vol.l4, No.6, Pecember 2002), pp. 773-779, ISSN 0955-0674... 

Kohler, C. Page, D.R. Gagliardini, V. Grossniklaus, U. (2005). The Arabidopsis thaliana MEDEA Polycomb group protein controls expression of PHERESl by parental imprinting. Nature Genetics, 37, No.l, (January 2005), pp. 28-30, ISSN 1061-4036... 

Platero J.S., Csink A.K., QuintanUla A., and Henikofif S. 1998. Changes in chromosomal localization of heterochromatin-binding proteins during the ceU cycle in Drosophila. J. Cell Biol. 140 1297—1306. Rastelli L., Chan C.S., and Pirrotta V. 1993. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer cf zeste function. EMBO J. 12 1513-1522. 

Surprisingly, C. elegans appears to have lost a considerable number of chromatin proteins from the Polycomb group of proteins, observed in Drosophila and in mammals, although other transcription factor genes... 

Apart from this HDACs are also associated with a number of other epigenetic repression mechanisms including histone methylation, polycomb group of proteins and DNA methylation (discussed later). The class II HDACs have been found to be involved in muscle development, particularly HDAC 5 and 9 knockouts or mutants show evidence of cardiac hypertrophy in a age or stress dependent manner (Zhang et al, 2002 Chang et al, 2004). 

Mahmoudi T, Verrijzer CP (2001) Chromatin silencing and activation by Polycomb and trithorax group proteins. Oncogene 20 3055-3066... 

Regulation of homeotic gene expression by the trithorax and polycomb groups of proteins... 

Flox expression patterns are sometimes maintained through positive autoregulatory loops, and through modulation of chromatin by proteins encoded by Polycomb-group and Trithorax-group genes. 

In the human tumor, prostate adenocarcinoma, the PRC 17 protein (polycomb group repressive complex) is encoded from the 17ql2 amplicon [524]. The PRC (prostate cancer) protein contains a GTPase-activating protein GAP domain related to the yeast ceU cycle regulators Bub2 and the RabA tp-specific GTPase activator... 

Jones CA, Ng J, Peterson AJ, Morgan K, Simon J, Jones RS. The Drosophila esc and E (z) proteins are direct partners in polycomb group-mediated repression. Mol Cell Biol. 1996 18 2825-34. 

Kohler, C. Hennig, L. (2010). Regulation of cell identity by plant Polycomb and trithorax group proteins. Current Opinion in Genetics Development, Vol.20, No.5, (October 2010), pp. 541-547, ISSN 0959-437X... 

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