Insecticide organophosphorus

Discovered in the late 1930s in Germany as improved poisonous insecticides, organophosphorus ChEIs were developed as chemical warfare agents (e.g. sarin, soman, and tabun) and were more recently employed in the 1995 terrorist attack in the Tokyo subway system [5]. 

Organophosphate Ester Hydraulic Fluids. A number of studies have been conducted on organophosphate ester hydraulic fluids because of the well known neurotoxic effects caused by organophosphorus insecticides, organophosphorus nerve gases, and tri-ort/w-cresyl phosphate (TOCP). The following manifestations of acute exposure to organophosphorus compounds have been described ... 

This technique has been used for the determination of polychlorobiphenyls, polychlorodibenzo-p-dioxins, polychlorodibenzofurans, alkyl phosphates, chlorinated insecticides, organophosphorus insecticides, triazine herbicides. Dacthal insecticide, insecticide/herbicide mixtures, mixtures of organic compounds and organotin compounds in soils, and polyaromatic compounds, polychlorobiphenyls, chlorinated insecticides and organotin compounds in non-saline sediments and anionic surfactants in sludges. 

In non-saline sediments aliphatic and polyaromatic hydrocarbons, phthalate esters carboxylic acids, uronic acid aldoses chloroaliphatics haloaromatics chlorophenols chloroanisoles polychlorobiphenyls polychlorodibenzo-p-dioxins poychlorodibenzofurans various organosulphur compounds, chlorinated insecticides, organophosphorus insecticides mixtures of organic compounds triazine herbicides arsenic and organic compounds of mercury and tin. 

A snpercritical flnid extraction (SEE) method for the determination in strawberries of a number of commonly used organochlorine insecticides, organophosphorus pesticides, and dichloroaniUde fungicides (Pearce et al., 1997). 

Methods for Determining Biomarkers of Exposure and Effect. Section 2.6.1 reported on biomarkers used to identify or quantify exposure to diazinon. Some methods for the detection of the parent compound in biological samples were described above. The parent chemical is quickly metabolized so the determination of metabolites can also serve as biomarkers of exposure. The most specific biomarkers will be those metabolites related to 2-isopropyl-6-methyl-4-hydroxypyrimidine. A method for this compound and 2-(r-hydroxy-l -methyl)-ethyl-6-methyl-4-hydroxypyrimidine in dog urine has been described by Lawrence and Iverson (1975) with reported sensitivities in the sub-ppm range. Other metabolites most commonly detected are 0,0-diethylphosphate and 0,0-diethylphosphorothioate, although these compounds are not specific for diazinon as they also arise from other diethylphosphates and phosphorothioates (Drevenkar et al. 1993 Kudzin et al. 1991 Mount 1984 Reid and Watts 1981 Vasilic et al. 1993). Another less specific marker of exposure is erythrocyte acetyl cholinesterase, an enzyme inhibited by insecticidal organophosphorus compounds (see Chapter 2). Methods for the diazinon-specific hydroxypyrimidines should be updated and validated for human samples. Rapid, simple, and specific methods should be sought to make assays readily available to the clinician. Studies that relate the exposure concentration of diazinon to the concentrations of these specific biomarkers in blood or urine would provide a basis for the interpretation of such biomarker data. 

It seemed likely that the failure of dichlorvos to induce mutations or tumours in mammals was due to the limiting effect of the known rapid metabolic degradation of this compound on the extent of methylation of DNA in vivo. Certainly in the case of such insecticidal organophosphorus compounds. 

Detection and Significance of Serum Insecticide Organophosphorus in Acute Organophosphorus Compound Poisoning... 

Uses 0/w emulsifier/solubilizer for oils, insecticides, organophosphorus compds. Arlypon 512 [Cognis]... 

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