Transition metals as mediators of disease processes

While physiological mechanisms usually regulate the amounts of essential elements in the body, for many other elements there are no such control mechanisms, and the amounts in the body reflect the occurrence in food or water. The amounts 

Transition metal Conditions associated with reduced availability or deficiency Conditions associated with excess availability or accumulation 

Chromium Altered glucose metabolism Glucose intolerance and malnutrition Liver and kidney impairment Dermatitis Convulsions and coma Respiratory tract and lung cancers (Cr(VI)) 

Cobalt Anaemia Cardiomyopathy/cardiac failure Respiratory sensitization and asthma Allergic dermatitis 

Copper Anaemia Menkes (kinky hair) syndrome Cardiac abnormalities/heart disease Wilson s disease Hepatic injury and jaundice Headache, vomiting Haemolytic shock 

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