1,2-Dimyristoyl

By contrast, a given synthetic preparation of a major phospholipid possesses fatty acid constituents all of identical chain length and unsaturation. A synthetic PC derivative can be purchased that contains only, for instance, 1,2-dimyristoyl (C14) fatty acid substitutions on its glyceryl... 

Figure 12.7t-A isotherm for 1,2-dimyristoyl lecithin at an n-heptane-aqueous NaCl solution interface. The numerals on the curves are the temperatures given in Celsius.

Fig. 6 Structure of membrane components (a) dioctadecyldimethylammonium bromide, (b) 1,2-dimyristoyl, s7i-glycero-3-phosphocholine (DMPC), (c) 1,2-dilauroyl, S7i-glycero-3-phospho-choline (DLPC), (d) dicetyl phosphate (DCP)...

Dimyristoyl-sn-glycero-3-phosphocholine monohydrate (dimyristoyl-L-a-lecithin)... 

Eight binary systems are reported. Six include cholesterol as one component of the mixed film. The second components in these six films were myristic acid, methyl palmitate, ethyl palmitate, 1,2-dimyristin, 1,2-dimyristoyl-3-lecithin, and l,2-didecanoyl-3-lecithin. In addition, the systems trilaurin-dimyristoyl lecithin and triolein-dimyristoyl lecithin... 

Figure 5. Mixed monolayers of cholesterol-1,2-dimyristoyl-3-lecithin system at 23°C., pH 6, and 5 dynes per cm.

Figure II. Surface pressure-area and surface potential-area plots for 1,2-dimyristoyl-3-lecithin, trilaurin, and a 1 to 1 molar mixture at 22°C.

Deuterated phospholipids l,2-dimyristoyl-.v -glycero-3-phosphocholinc (DMPC-c/s4), 1,2-dimyristoyl-.s -glyccro-3- phospho-rac-( 1 -glycerol) (DMPG-J54), and L2-dihexanoyl-.sy -glyccro-3-phosphocholinc (DHPC-c/22) as well as the undeuter-ated DMPC, DMPG, and DHPC Avanti Polar Lipids, Alabaster (AL, USA)... 

An example of how the procedure works is shown in Figure 18.5. The peptide in this example is MSI-103, which has been labeled with 19F at the four positions indicated in Figure 18.5a. Four different peptides were synthesized where a single amino acid (Ala-7, Ile-9, Ala-10, or Ile-13) was replaced with CF3-Phg. For each label a 19F NMR spectrum is recorded (see Figure 18.5a) in this example, spectra are from MSI-103 in DMPC (1,2-dimyristoyl-OT-glycero-3-phosphocholine) at a peptide-to-lipid molar ratio (P/L) = 1 400,... 

Hydrogenated egg phosphatidylcholine [HPC], sphingomyelin [SM], phosphatidic acid [PA], 1,2-dimyristoyl-OT-glyceroyl-3-PC[DMPC],l,2-dipalmitoyl-rw-glyceroyl-3-PC... 

Dimyristoyl-r -Glycero- 3 -Phosphoethanolamine (DMPE). Diphytanoyl Phosphoethanolamine. 

Lipkowski and coworkers [328] have employed STM to study the spreading of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcho-line vesicles into the film at the Au(lll) electrode surface. During the initial stage, phospholipid molecules were adsorbed flatly with the acyl chains oriented parallel to the surface and assembled into an ordered monolayer similar to that formed by alkanes. Later, the molecules reoriented and the monolayer was transformed into a hemimicellar film. 

Dimyristoyl-sn-glycero-3-phosphochoIine monohydrate (dimyristoyl>L a>lecithin)... 

The structurally somewhat more complicated lipids may show in the pure state quite similar sequences of phase transitions as the soaps. Their behavior may be illustrated by the transitions of 1,2-dimyristoyl-DL-phosphatidylethanolamine [CH3-(CH2-),2C0-0-]CH2[CH3(CH2-)oC0-0-]CH-CH2-[0-P0r - 0-(CH3-)2-NH >]. 

Fig.1 Different platforms for biomolecule immobilization or biosensor surface modifications a reactive ester-terminated SAM on gold b substrate-supported lipid bilayer on glass (structure of 1.2-dimyristoyl-sM-glycero-3-phosphatidylcholine, DMPC) c substrate-immobilized lipid vesicle d spin-coated thin film of a reactive homopolymer, such as poly(JV)-hydroxysuccinimidyl methacrylate (PNHSMA with tunable thickness dfiim the reactive groups are located in a region near the surface with depth the reactant molecules and reactive moieties in the film are schematically depicted as bars and dots, respectively)...

Champeil, MoUer, 2000). Some lipid/detergent mixtures have been used in nuclear magnetic resonance (NMR) and crystallization experiments (Seddon, Cumow, Booth, 2004) in structural and functional studies of the extremely light-sensitive G protein-coupled receptor (GPCR), rhodopsin, Reeves et al. used a mixture of the lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine and the detergent 3-[(3-cholamidopropyl)-dimethylammonio]- -propane-sulfonate (CHAPS) (Reeves, Hwa, Khorana, 1999). 

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