Dimyristoyl-phosphatidyl-choline

We report here the results of a study of the adsorption of the alkaline earth cations to bilayer membranes formed from phosphatidylcholines with saturated chains dipalmitoyl phosphatidyl choline (DPPC) and dimyristoyl phosphatidyl choline (DMPC). Our salient result is that the adsorption of calcium is distinct from the other alkaline earth cations in two respects. First, only calcium adsorbs significantly more strongly to PCs with saturated chains than to phosphatidyl cholines with unsaturated chains, even when all lipids are present in the liquid crystalline state. Second, when the membranes are present in the frozen or gel state, the binding of calcium is significantly enhanced. We used two independent techniques to demonstrate this unique behavior of calcium. [Pg.53]

Figure 8-10 NMR spectra of dimyristoyl phosphatidyl-choline-d27/water in lamellar phases at 40°C. One chain of the phosphatidylcholine is fully deuterated, containing 27 atoms of H. The mole ratios of water to lipid were 5.0 in (A) and 25.0 in (B). The average interfacial areas per alkyl chain as measured by X-ray diffraction were 0.252 nm for (A) and 0.313 nm for (B). NMR spectra are presented as "powder patterns" because the lipid molecules are randomly oriented in the magnetic field of the spectrometer as if in a powder. This gives rise to pairs of peaks symmetrically located on both sides of the origin. The separation distances are a measure of the quadrupole splitting of the NMR absorption line caused by the nucleus. The various splittings of the resonances of the 13 -CH2- and one -CH3 groups reflect differences in mobility. The peaks have been assigned tentatively as indicated. From Boden, Jones, and Sixl. Courtesy of N. Boden.

$Figure 8-10 NMR spectra of dimyristoyl phosphatidyl-choline-d27/water in lamellar phases at 40°C. One chain of the phosphatidylcholine is fully deuterated, containing 27 atoms of H. The mole ratios of water to lipid were 5.0 in (A) and 25.0 in (B). The average interfacial areas per alkyl chain as measured by X-ray diffraction were 0.252 nm for (A) and 0.313 nm for (B). NMR spectra are presented as "powder patterns" because the lipid molecules are randomly oriented in the magnetic field of the spectrometer as if in a powder. This gives rise to pairs of peaks symmetrically located on both sides of the origin. The separation distances are a measure of the quadrupole splitting of the NMR absorption line caused by the nucleus. The various splittings of the resonances of the 13 -CH2- and one -CH3 groups reflect differences in mobility. The peaks have been assigned tentatively as indicated. From Boden, Jones, and Sixl. Courtesy of N. Boden.$

A variety of weak liquid crystalline media have been used to align carbohydrates. Examples include Pfl phage,147-150 filamentous bacteriophage fd,151 C12E5/ -hexanol,77,152-154 C8E5/ -octanol,155 cetylpyridinium bromide / -hexanol /NaCl,73,156-158 DMPC/DHPC (dimyristoyl-phosphatidyl choline / dihexanoyl-... [Pg.207]

Patel, H Schultz, T.W. and Cronin, M.T.D. (2002) Physico-chemical interpretation and prediction of the dimyristoyl phosphatidyl choline-water partition coefficient. J. Mol. Struct. (Theochem), 593, 9-18. [Pg.1137]

This model system studies the antioxidant potential against the attack of oxygen radicals on biomembranes from aqueous phase [52]. Antioxidant effects of olive phenols depend on their interaction with model membranes [53], e.g., oleuropein interacts with DMPC (dimyristoyl-phosphatidyl-choline) membranes. Oleuropein contains a sugar moiety needed to prevent drug access to lipid membranes [54]. In... [Pg.878]

Figure 2.2.6 Crystal structure of dimyristoyl-phosphatidyl-choline (DMPC). (a) Molecular structure. A- and B-forms (b) bilayer crystal sheets, A form..

Recently, the competitive adsorption dynamics of phospholipid/protein mixed system at the chloroform/water interface was investigated by using the drop volume technique. The three proteins P-Lactoglobulin, P-Casein, and Human Serum Albumin were used in this study. To investigate the influence of the phospholipid structure at concentrations close to the CAC (critic aggregation concentration) the four lipids dipalmitoyl phosphatidyl choline (DPPC), dimyristoyl phosphatidyl choline (DMPC), dimyristoyl phosphatidyl ethanolamine (DMPE)... [Pg.373]

The nomenclature for associating individual fatty acid groups with particular phosphodig-lyceride derivatives is straightforward. For instance, a phosphatidic acid (PA) derivative which contains two myristic acid chains is commonly called dimyristoyl phosphatidic acid (DMPA). Likewise, a PC derivative containing two palmitate chains is called dipalmitoyl phosphatidyl choline (DPPC). Other phosphodiglyceride derivatives are similarly named. [Pg.866]

Phospholipids Soybean lecithin Egg lecithin Diolelyl phosphatidyl choline Distearoyl phosphatidyl glycerol PEGylated phospholipids Dimyristoyl phosphotidyl choline All routes... [Pg.264]

Similar intra- and inter-molecular dispersion effects have been estimated in the case of phosphatidyl choline (PC) lipids, with two acyl chains of 12 (dilauroyl, DL), 14 (dimyristoyl, DM), and 16 (dipalmitoyl, DP) CH2 units. The conformational analysis of these Upids has shown the existence of two relative orientations of the chains with close energies, having their carbon backbones in parallel and in perpendicular planes [80]. [Pg.19]

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