7,12-Dimethylbenz cancer

A stmcturally related series of phenyfiiydrazones resulted ia the selection of compound A-007 [2675-35-6] (DEKK-TEC)(37) for the treatment of hormone-dependent tumors. A-007 is an antiestrogen that, ia contrast to tamoxifen, demonstrated inhibitory activity both ia the presence and absence of estradiol ia ZR-75-1 estrogen-dependent human breast cancer cells, and afforded more protection than tamoxifen ia the 7,12-dimethylbenz[i7]anthracene... 

Jung KJ, Wallig MA and Singletary KW. 2006. Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 233 279-288. 

Wang ZY, Huang M, Lou Y, Xie J, Reuhl K, Newmark H, Ho C, Yang C and Conney A. 1994. Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[<3]anthracene-initiated SKH-1 mice. Cancer Res 54(13) 3428-3435. 

Li S, Levesque C, Geng CS, Yan X, Labrie F (1995) Inhibitory effects of medroxyprogesterone acetate (MPA) and the pure antiestrogen EM-219 on estrone (El)-stimulated growth of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat. Breast Cancer Res Treat 34 147-159... 

Constantinou AI, Mehta R, Husband A. (2003) Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. Fur J Cancer 39 1012-1018. 

In vivo, letrozole (3) was efficacious in two animal models. One was a postmenopausal hormone-dependent breast cancer mouse model, the other was a dimethylbenz[a]-anthracene (DMBA)-induced mammary carcinoma rat model. 

Relationship between amount and type of dietary fat in promotion of mammary carcinogenesis induced by 7,12-dimethylbenz[a] anthracene. J Natl Cancer Inst 1979 62(4) 1009-1012. 

Anti-thyroid activity. Boiled rice taken orally by adults at a dose of 350 g/person was inactive on iodine uptake by the thyroid Anti-tumor activity. Bran, administered intraperitoneally to mice at a dose of 100 mg/kg, was active on Sarcoma 180 (solid). The biological activity has been patented . Fermented grains, in the ration of rats, were active. Miso, a paste made from the seeds of Oryza sativa and G lycine max (soybean), was fed ad libitum. The incidence of cancers in the miso treated rats was 20% less than controls vs 7,12-dimethylbenz-[a]anthracene -induced carcinogenesis ". Water extract of dried seed hull, administered intraperitoneally to mice, was active on Sarcoma 180 (ASC). A glycoprotein fraction has been tested. The biological activity reported has been patented . Anti-ulcer activity. A cerebroside fraction of rice bran, administered intraperitoneally to mice at a dose of 100 mg/kg, was inac-... 

Marchok, A.C., Rhoton, J.L., Griesemer, R.A., and Nettesheim, P. (1977). Increased in vitro growth capacity of tracheal epithelium exposed in vivo to 7,12-dimethylbenz[a]anthracene, Cancer Res. 37,1811. 

Slaga, T.J. and Boutwell, R.K. (1977). Inhibition of the tumo initiatmg ability of the potent carcinogen 7,12-dimethylbenz[a]anthracene by the weak tumor initiator 1,2,3,4-dibenzanthracene," Cancer Res. 37,128. 

Phang JM, Poore CM, Lopaczynska J, Yeh GC. 1993. Flavonol-stimulated efflux of 7,12-dimethylbenz(a)anthracene in multidrug-resistant breast cancer cells. Cancer Res 53 5977-5981. 

Banerjee S, Bueso-Ramos C, Aggarwal BB. 2002. Suppression of 7,12-dimethylbenz (a)anthracene-induced mammary carcinogenesis in rats by resveratrol Role of nuclear factor-KB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 62 4945 1954. 

Saarinen, N.M., Huovinen, R., Varri, A., Makela, S.I., Valentin-Blasini, L., Sjoholm, R., Ammala, J., Lehtila, R., Eckerman, C., Collan, Y.U., and Santii, R.S. 2002. Enterolactone inhibits the growth of7, 12-dimethylbenz (a) anthracene-induced mammary carcinomas in the rat. Mol. Cancer Ther. 

Cohen GM, Bracken WM, Iyer RP, et al. 1979. Anticarcinogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene tumor initiation and its relationship to DNA binding. Cancer Res 39 4027-4033. 

My interest in the influence of diet on hormone-dependent cancers was first stimulated about 20 years ago by studies carried out in collaboration with colleagues at the Collip Medical Research Laboratory of the University of Western Ontario. They were involved in studies on the role of hormones in mammary cancer and for this purpose were inducing tumors in rats with 7,12-dimethylbenz(oi)-anthracene (DMBA) as described by Huggins et al ( 1). They were concerned to know whether hormonal treatment might affect tumorigenesis by altering the degree and time of exposure of mammary... 

Our laboratory has completed a series of studies designed to evaluate the simultaneous effects of dietary protein and fat on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats. Sprague-Dawley female rats were assigned to nine diets in a 3 x 3 factorial arrangement with protein (casein) at 8, 16, and 32% of kcals and fat (corn oil) at 12, 24, and 48% of kcals. As fat content was increased, all nutrients other than carbohydrate were adjusted to remain constant with respect to calories. Forty rats were assigned to each diet for each of three experiments (Figure 1) to examine initiation, promotion, and the combined phases of chemically-induced carcinogenesis. 

Dimethylbenz( a) anthracene (DMBA)-induced mammary carcinoma in the rat is a widely used animal model to study the factors that control hormone-sensitive breast cancer in women. In fact, the development and growth of these tumors are particularly sensitive to the stimulatory action of estrogen and prolactin (Asselin et al., 1977 Asselin and Labrie, 1978 Dauvois and Labrie, 1990 Dauvois et al., 1989b Huggins et al., 1961 Jordan and Allen, 1980 Kelly et al., 1977, 1979 Labrie et al., 1976, 1993 Leung etal., 1975 Li et al., 1993, 1995 Welsch, 1985). 

Morse MA, Baird WM, Carlson GP. Distribution, covalent binding, and DNA adduct formation of 7,12-dimethylbenz(a)anthracene in SENCAR and BALB/c mice following topical and oral administration. Cancer Res 1987 47 4571-5. 

Verma, A.K. et al., Inhibition of 7,12-dimethylbenz(a)-anthracene- and N-nitrosom-ethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Res., 48, 5754, 1988. 

Deshpande, S.S., Ingle, A.D., and Mam, G.B., Chemopreventive efficacy of curcumin-free aqueous turmeric extract in 7,12-dimethylbenz[a] anthracene-induced rat mammary tumorigenesis. Cancer Lett., 123, 35, 1998. 

As mentioned earlier that sesame lignans, especially sesamin and epi-sesamin, could influence the metabolism of polyunsaturated fatty acid and the production of prostaglandins. As prostaglandin is one of the most influential factors for mammary carcinogenesis, Hirose et al. (99) studied the effect of sesamin on dimethylbenz-anthracene (DMBA)-induced mammary cancer. Their results showed that sesamin at a dietary level of 0.2% considerably reduced the cumulative number and mean number of mammary cancer the effectiveness of sesamin was similar to a-tocopherol. 

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