Transcription, modulating

Cassatella, M. A., Bazzoni, F., Calzetti, F., Guasparri, I., Rossi, F., Trinchieri, G. (1991). Interferon-/transcriptionally modulates the expression of the genes for the high affinity IgG-Fc receptor and the 47-kDa cytosolic component of NADPH oxidase in human polymorphonuclear leukocytes. J. Biol. Chem. 266, 22079-82. 

Ihmels, ]., Bergmann, S., and Brkai, N. (2004) Defining transcription modules using large-scale gene expression data. Bioinformatics 20, 1993-2003. 

Another class of transcription-modulating drugs is the immunosuppressants such as cyclosporin A (CsA), which inhibit T cell activation and proliferation, events playing a central role in the immune response and therefore in the inflammatory process. CsA blocks transcriptional induction of cytokines by inhibiting the phosphatase calcineurin, and by the subsequent inhibition of the activation of NF-AT and NF-AT-dependent activation genes. 

Dey, M. et al., Transcriptional modulation and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate, J. Pharmacol. Exp. Ther., 317(1), 326, 2006. 

Ihnatko, R., M. Kubes, M. Takacova, O. Sedlakova, J. Sedlak, J. Pastorek, J. Kopacek, and S. Pastorekova. Extracellular Acidosis Elevates Carbonic Anhydrase IX in Human Glioblastoma Cells via Transcriptional Modulation That Does Not Depend on Hypoxia. International Journal of Oncology 29, no. 

Cippitelli, M. and Santoni, A. (1998) Vitamin D3 a transcriptional modulator of the interferon-"/ gene. European Journal of Immunology, 28, 3017-3030. 

Kaufer, D., Friedman, A., and Soreq, H., The vicious circle Long-lasting transcriptional modulation of cholinergic neurotransmission following stress and anticholinesterase... 

Li, B.-H., Ebbert, A., and Bockrath, R. (1999). Transcription-modulated repair in Escherichia coli evident with UV-induced mutation spectra in supF. J. Mol. Biol. 294, 35-48. 

Jones N (1995) Transcriptional modulation by the adenovirus El A gene. Curr Top Microbiol Immunol 199 ( Pt 3) 59-80... 

The understanding of the mechanism by which retinoids modulate gene expression implies that retinoids activate a signal-transduction pathway in which nuclear-retinoid receptors, which are members of the steroid hormone-receptor superfamily, play a pivotal role (14,16,18-22). Like other members of this family, the retinoid receptors are ligand-activated, DNA-binding transacting, transcription-modulating proteins. Two types of receptor have been identified retinoic acid receptors (RARs) and retinoid X receptors (RXRs) each type includes three subtypes of RAR (a, p, and y) and of RXR (a, P, and y) with distinct ammo- and carboxy-terminal domains. RXR-RAR... 

Cantoma MT, Nashold FE, Hayes CE (1994) In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Till and insufficient Th2 function. 7 Immunol 152 1515-1522 Cippitelli M, Ye J, Viggiano V, Sica A, Ghosh P, Gulino A, Santoni A, Young HA (1996) Retinoic acid-induced transcriptional modulation of the human interferon-y promoter. J Biol Chem 271 26 783-26 793 Bhatti L, Sidell N (1994) Transcriptional regulation by retinoic acid of interleukin-2a receptors in human B cells. Immunology 81 273-279... 

Montserrat P., H. Hackl, T. Rainer Burkard, A. Prokesch, C Papak, M. Scheideler, G. Hammerle, R. Zechner, Z. Trajanoski and J.G. Strauss, 2008. Differential transcriptional modulation of biological processes in adipocyte triglyceride lipase and hormone-sensitive lipase-deficient mice Genomics 92, 26-32. 

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