Dextran sulfate sodium colitis

Naito, Y., Takagi, T., Ishikawa, T., Handa, O., Matsumoto, N., Yagi, N., Matsuyama, K., Yoshida, N., Yoshikawa, T., The inducible nitric oxide synthase inhibitor ONO-1714 blunts dextran sulfate sodium colitis in mice, Eur. ]. Pharmacol. 412 (2001), p.91-99... 

OA were aborted in 2003 due to the development of mild to moderate liver fibrosis in dogs treated for 9 months with high doses of pralnacasan. This was in spite of recent evidence demonstrating the effectiveness of pralnacasan treatment in the acute dextran sulfate sodium (DSS)-induced colitis model, which resembles Crohn s disease (CD) characteristics, and in transient ischemia induced brain damage. 

HV143 Araki Y., Y. Fujiyama, A. Andoh, S. Koyama, O. Kanauchi, and T. Bamba. The dietary combination of germinated barley foodstuff plus Clostridium butyricum suppresses the dextran sulfate sodium-induced experimental colitis in rats. Scand J Gastroenterol 2000 35(10) 1060-1067. 

Effects of germinated barley foodstuff on microflora and short chain fatty acid production in dextran sulfate sodium-induced colitis in rats. Biosci Biotechnol Biochem 2000 64(9) 1794-1800. 

Colon Dextran sulfate sodium Increased expression of pro- inflammatory mediators (TMFa, iNOS, COX-2, cytokines), rectal bleeding, increased colitis severity, increased number of colonic aberrant crypt foci, increased lipid peroxidation Khor et al. (2006) Osbum et al. (2007)... 

Khor TO, Huang MT, Kwon KH, Chan JY, Reddy BS, Kong AN (2006) Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res 66 11580-11584... 

Cooper, H.S. et al.. The role of mutant Ape in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis, Gastroenterology, 121 (6), 1407, 2001. 

Helminths may not inhibit or modulate all types of inflanunation. Mice with oxazalone colitis, another model of intestinal inflammation, develop worse disease if colonized with the tape worm Hymenolepis diminuta. Yet, exposure to this helminth protects fi om TNBS-like colitis and improves some aspects of dextran sulfate sodium (DSS) colitis. Similarly, mice with mixed-sex S. mansoni infections are more susceptible to DSS-induced colitis relative to uninfected mice, while schistosome male worm-only infections are refraaory to DSS colitis. ... 

Reardon C, Sanchez A, Hogaboam CM et al. Tapeworm infection reduces epithelial ion transport abnormalities in murine dextran sulfate sodium-induced colitis. Infection and Immunity 2001 69(7) 4417-4423. 

CB2-receptors also exist, in low levels, in cells of the gastrointestinal and cardiovascular system, bone and neuronal cells, liver tissue, and other ceU types [26]. CB2 is up-regulated in inflamed colonic tissue of colitis patients. It is believed that the CB2-receptors are in close interaction with the PPARy-receptor, and both are considered targets for treatment of inflammatory bowel diseases. That was the motivation for Bento et al. [27] to investigate the effect of oral BCP in DSS (dextran sulfate sodium)-induced colitis experimental models. The results showed that BCP inhibited the influx of inflammatory cells. 

Bento AF, Marcon R, Dutra RC, Claudino RF, Cola M, Leite DF, Calixto JB (2011) P-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CBa receptor activation and PPARy pathway. Am J Pathol 178(3) 1153-1166... 

Osman, N., Adawi, D., 7 hme, S., Jeppsson, B., and Molin, G. 2004. Modulation of the effect of dextran sulfate sodium-induced acute colitis by the administration of different probiotic strains of Lactobacillus and Bifidobacterium. Dig Dis Sci 49(2), 320-327. 

Shi et al., [25] investigated the pharmacokinetics and tissue distribution of SFE extracts obtained from Libanotis buchtormensis. Cho et al., [26] observed that the CO2-SFE extract from Lepidium meyenii relieves symptoms of diarrhea and rectal bleeding caused by colitis induced by dextran sulfate sodium in rats. 

Tokuyama H, Ueha S, Kurachi M, et al. The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis. Int Immunol 2005 17 1023-1034. 

Gewirtz AT, Collier-Hyams LS, Young AN, Kucharzik T, Guilford WJ, Parkinson JF, Williams IR, Neish AS, Madara JL (2002) Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol 168 5260-5267... 

Andres, P. G., Beck, P. L., Mizoguchi, E., Mizoguchi, A., Bhan, A. K., Dawson, T., Kuziel, W. A., Maeda, N., MacDermott, R. P., Podolsky, D. K., and Reinecker, H. C. (2000). Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis Lack of CC chemokine receptor 5 expression results in a NKl.l-i- lymphocyte-associated Th2-type immune response in the intestine. J. Immunol. 164, 6303-6312. 

Bertolotti, A., Wang, X., Novoa, I., Jungieis, R., Schlessinger, K., Cho, J.H., West, A.B. andRon, D. (2001) Increased sensitivity to dextran sodium sulfate colitis in IRE Ibeta-deficient mice. J. Clin. Invest. 107, 585-593. 

Colitis 2% Dextran sodium sulfate in drinking water Reduction in severity of clinical symptoms of colitis. No change in the levels of CC chemokine production or leukocyte recruitment compared to wild type. Elevated IL-17 production from yb Tcells contributes to protection. 

The second example of what might be considered to be an unexpected D6 null phenotype came from our studies using the dextran sodium sulfate (DSS)-induced model of colitis [29]. D6 is abundantly expressed in the colon and upregulated during colitis in wildtype mice. However, we found that D6 null mice had a reduced tendency to develop the clinical symptoms of colitis compared to their wildtype counterparts, and had neither altered levels of bioavailable inflammatory CC chemokines nor... 

Vidda, S., Vilaseca, J., Antolin, M. et al (2001) Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat. Am. J. Gastroenterol, 96,1486-1493. 

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