Dextran sulfation

Many covalentiy modified derivatives of dextran have been described. Of these, the most important are dextran sulfate [9042-14-2] and cross-linked dextran. The uses and properties of these and other dextran derivatives have been reviewed (66,69,71—73,203). 

Protease nexin (From cultured human fibroblasts) [148263-58-5], Purified by affinity binding of protease nexin to dextran sulfate-Sepharose. [Farrell et al. Biochem J 237 707 1986.]... 

OA were aborted in 2003 due to the development of mild to moderate liver fibrosis in dogs treated for 9 months with high doses of pralnacasan. This was in spite of recent evidence demonstrating the effectiveness of pralnacasan treatment in the acute dextran sulfate sodium (DSS)-induced colitis model, which resembles Crohn s disease (CD) characteristics, and in transient ischemia induced brain damage. 

DISC, death inducing signaling complex DSS, dextran sulfate sodium FLIP, caspase-8 (FLICE) inhibitory protein... 

A hydrogel with high sensitivity was prepared with chitosan (DA = 0.18) and dextran sulfate the maximum volume of the complex gel was observed in a dilute NaOH solution at pH 10.5, and was about 300 times as large as the volume at pH values below 9 [106,107]. 

Callahan LN, Phelan M, Mallinson M, Norcross MA. Dextran sulfate blocks antibody binding to the principal neutralizing domain of human immunodeficiency virus type 1 without interfering with gpl20-CD4 interactions. J Virol 1991 65 1543-1550. 

Lorentsen KJ, Hendrix CW, Collins JM, Kornhauser DM, Petty BG, Klecker RW, Flexner C, Eckel RH, Lietman PS. Dextran sulfate is poorly absorbed after oral administration. Ann Intern Med 1989 111 561-566. 

Modified procedure HDL plasma—plasma depleted with apo B-con-taining lipoproteins by pretreatment with dextran sulfate/Mg2+ HDL reagent (Sigma, procedure 352-3). Plasma LDL-bound antiradical parameters can be calculated as the difference between ACW/ACL/ACL0 for whole plasma and for HDL plasma as well. 

Dextran Sulfate Medium Permanent Medium Rigid Cyclic Side Chain Strong... 

Cellulose Sulfate Chondroitin 4-Sulfate Chondroitin 6-Sulfate Dextran Sulfate Gellan Gum Gelatin A (pH = 9.0) Gelatin B (pH = 6.5)... 

Naito, Y., Takagi, T., Ishikawa, T., Handa, O., Matsumoto, N., Yagi, N., Matsuyama, K., Yoshida, N., Yoshikawa, T., The inducible nitric oxide synthase inhibitor ONO-1714 blunts dextran sulfate sodium colitis in mice, Eur. ]. Pharmacol. 412 (2001), p.91-99... 

---