Developmental maturity

Pediatric patients require other special considerations when prescribing a dmg that requires therapeutic monitoring. Simply obtaining blood samples can be difficult, depending on the age, developmental maturation, and hydration status of the child. In some clinical settings, a lack of personnel comfortable with pediatric phlebotomy makes sample collection even more difficult, or even hazardous. As well, some facilities lack on-site laboratories for... 

The androgen testosterone is made in the testis and directs developmental maturation of male sex characteristics and normal function of male sex organs. Anabolic—androgenic steroid analogue drugs have been developed for increasing muscle mass. 

Developmental Maturation is a progressive acquisition of competence of the CA to synthesize JH, which normally proceeds in conjunction with developmental changes associated with increase in gland volume... 

Short-Term Modulation - allatotropic and allatostatic - is superimposed on the basal activities of developmentally mature CA. Locust cerebral allatotropin was first demonstrated in vitro in methanolic brain and corpora cardiaca (CC) extracts (14.15) and allatotropin I was later partially purified and characterized (16). Allatotropin I is found in high concentrations in the brain, where it is presumably synthesized, and in corpora cardiaca (CC) to where it is presumably transported and released as required. The exact location of allatotropin synthesis in the brain is still unknown. Ovarian allatostatin rapidly depresses allatotropin-stimulated JH synthesis (17). This allatostatic factor is methanol soluble and... 

Reserpine treatment retards the development of allatal competence of locust females for several weeks, but basal rates appear to be normal (32). This indicates that development of the two key enzyme systems are not dependent one on the other. Reserpine acts in vertebrate systems by depleting monoamine transmitter substances in the central nervous system (33) and has been shown to activate peptidergic neurosecretory pathways in insects (34.35. The differential response to reserpine in the locust CA suggests that part of the process of developmental maturation may be dependent on neurosecretion. 

Martin RE, De Turco EBR, Bazan N. Developmental maturation of hepatic n-3 polyunsaturated fatty acid metabolism supply of docosahexaenoic acid to retina and brain. J Nutral Biochemistry 1994 5 151-160. 

Fig. 2. Somatic embryogenesis in Hinoki cypress. A Collected open-pollinated cones. B Proliferation of induced embiyogenic tissue on medium containing auxin and cytokinin. C Embryogenic cells. D-F Different developmental maturation stages of somatic embryos. G Production of somatic embryos. H Germination of somatic embryos. I Plantlets growing in vitro. J Acclimatized plants derived from somatic embryos. K-L Somatic plants growing out in the field. Bars 1mm (C-F), 1cm (A-B, G-J), Im (K-L)...

The growth of animals can be defined as an increase in mass of whole body, tissue(s), organ(s), or ceU(s) with time. This type of growth can be characterized by morphometric measurements eg, skeletal muscle or adipose tissue growth can be described by observing temporal changes in ceU number, ie, hyperplasia, and ceU size, ie, hypertrophy. Growth also includes developmental aspects of function and metaboHsm of cells and tissues from conception to maturity. 

Developmental Toxicity—The occurrence of adverse effects on the developing organism that may result from exposure to a chemical prior to conception (either parent), during prenatal development, or postnatally to the time of sexual maturation. Adverse developmental effects may be detected at any point in the life span of the organism. 

B) at the indicated stages, and the PGl, PG2, and total PG activities were determined by differential heat inactivation. Each time point is the average of at least two separate extractions assayed in duplicate. The developmental stages are MG, mature green Br, breaker stage, (time of first external color development) and +2, +5, +7, and +10 are days after breaker. 

Figure 3. Developmental pattern of expression of PE2 and PE3 in pods and other tissues of green bean cultivar Verona. Numbered samples concur with the following developmental stages in Days Post Flowering (DPF). 1 1-5 DPF, 2 6-7 DPF, 3 8-11 DPF, 4 12-22 DPF, 5 23-35 DPF. Abbreviations Y.pods = Young pods, D. pods = Deseeded pods, rt. If and fl represent root, leaf and flower tissue respectively. Mature green (MG) tomato RNA was probed with tomato pPEl [5],...

In the OE of jawed fish only cellular, and little if any, tissue specialisation is achieved. During metamorphosis from tadpole to adult in amphibia, a developmental parallel of water-to-land transition includes the timing of maturation of the AOS. The system as it appears in living amphibians, is already a more or less discrete entity (Fig. 4.3) with its own sub-set of receptors. A process of regionalisation within the bulb, already underway even at the level of organisation in cartilaginous fishes, shows parallel adjustments (Dryer and Graziadei, 1993). 

The VN cartilage, the VN glands and the vasomotor network are all functionally necessary components without whose various contributions the receptor cells would be unlikely to function. These ancillary constituents show a parallel developmental sequence. The cartilage may become partly ossified and incompletely surrounds the organ, the enclosure lessening towards the posterior end. In the mature organ, maximum enclosure is usually found along the sensory section. 

Bowman EP, Campbell JJ, Soler D, et al. Developmental switches in chemokine response profiles during B cell differentiation and maturation. J Exp Med 2000 191 1303-1318. 

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